BPS Program Book 2014

1564-P os B oard #B294 HIGHLY ENHANCED CONFORMATIONAL SAMPLING OF THE TRANSMEMBRANE DOMAIN OF EGF RECEPTOR SHEDS LIGHT ONTHE ACTIVATIONMECHANISM. Mickael G. Lelimousin , Vittorio Limongelli, Mark S. P. Sansom 1565-P os B oard #B295 DIMERIZATION OF TRANSMEMBRANE HELICES OF RECEPTORTYROSINE KINASES: ASSESSINGTHE CONVERGENCE OF COARSE-GRAINEDMOLECULAR DYNAMICS SIMULATIONS. Amanda Buyan , Khairul Abd Halim, Mark S.P. Sansom 1566-P os B oard #B296 ASSOCIATION OF EPHA2 RECEPTOR WITH THE MEMBRANE THROUGH ITS SECOND FIBRONECTIN DOMAIN: A BIOPHYSICAL AND COMPUTATIONAL STUDY. Matthieu G. Chavent , Elena Seiradake, E Yvonne Jones, Mark S. P. Sansom 1567-P os B oard #B297 CATIONIC LIPID AND BACTERIAL LIPOPOLYSACCHARIDES BOTH ACTIVATE TOLL-LIKE RECEPTOR 4 PATHWAYS VIA DIFFERENT BINDING REGIONS. Caroline Lonez, Kate Irvine, Monique Gangloff, Malvina Pizzuto, Boris Schmidt, Benjamin Caroyez, Michel Vandenbranden, Clare Bryant, Jean-Marie Ruysschaert 1568-P os B oard #B298 ACTIVATION PATHWAYS OF KINASES REVEAL INTERMEDIATE STATES AS NOVEL TARGETS FOR DRUG DESIGN. Diwakar Shukla , Benoit Roux, Vijay S. Pande 1569-P os B oard #B299 TOWARDS THE RATIONAL DESIGN OF OPIOIDS WITH DESIRED BINDING KINETICS. Sebastian Schneider , Davide Provasi, Marta Filizola 1570-P os B oard #B300 COMPUTATIONAL PREDICTION OF THE CLASS A GPCR ACTIVE STATE CONFORMATIONS. Sijia S. Dong , Ravinder Abrol, William A. Goddard III 1571-P os B oard #B301 cpow travel awardee EXPLORING THE STRUCTURE AND DYNAMICS OF ALL-ATOM MODELS FOR THE PLEXIN TRANSMEMBRANE RECEPTOR BOUND TO GTPASES AND TO LIPID BILAYER. Liqun Zhang , Matthias Buck 1572-P os B oard #B302 TWO SEGMENTS OFTHE HUMAN PIEZO1 MECHANOSENSITIVE ION CHANNEL CAN REASSEMBLE INTO A FUNCTIONAL UNIT. Philip A. Gottlieb , Chilman Bae, Thomas Suchyna, Frederick Sachs 1573-P os B oard #B303 UNIQUE SIGNALING LOGIC WITHIN A BACTERIAL CELL CYCLE CIRCUIT. W. Seth Childers , Qingping Xu, Irimpan I. Mathews, Thomas H. Mann, Jimmy A. Blair, Ashley M. Deacon, Lucy Shapiro Exocytosis and Endocytosis I (Boards #B304–#B320) 1574-P os B oard #B304 MODELING NANOPARTICLE INTERNALIZATION VIA RECEPTOR-MEDIATED ENDOCYTOSIS. Anand Banerjee , Alexander Berezhkovskii, Ralph Nossal 1575-P os B oard #B305 SELF-ASSOCIATION AND DYNAMIN BINDING OF ARC/ ARG3.1. Nicholas G. James , Christopher E. Byers, Barbara Barylko, Joseph P. Albanesi, David M. Jameson

1576-P os B oard #B306 ELUCIDATING THE MECHANICS OF CLATHRIN-MEDIATED ENDOCYTOSIS. Ashutosh Agrawal , Nikhil Walani, Jennifer Torres 1577-P os B oard #B307 DYNAMICS OF INTRACELLULAR CLATHRIN CARRIERS. Comert Kural , Steeve Boulant, Tomas Kirchhausen 1578-P os B oard #B308 REAL-TIME ENDOCYTOSIS IMAGING AS A RAPID ASSAY OF LIGAND-GPCR BINDING IN SINGLE CELLS. Lianghong Zheng , Quanfeng Zhang, Ruiyin Jiao, Rong Huang, Suhua Sun, Zuyin Chai, Mingli Li, Xi Wu, Wei Liu, Qihui Wu, Sasa Ten, Changhe Wang, Liecheng Wang, Wei Xiong, Zhuan Zhou 1579-P os B oard #B309 ROLE OF INTERNALIZATION OF CELL SURFACE RECEPTORS IN REGULATION OF CELL POLARITY. Wei Tian , Youfang Cao, Amber Ismael, David Stone, Jie Liang 1580-P os B oard #B310 MOLECULAR MECHANISMS OF ENDOCYTOSIS AND EXOCYTOSIS IN YEAST STUDIED BY HIGH-RESOLUTION MEMBRANE CAPACITANCE MEASUREMENTS. Lucia Carrillo, Gerhard Thiel, Adam Bertl 1581-P os B oard #B311 CELLULAR SCALE BIOPHYSICAL MODELS OF MEMBRANE SCULPTING BY THE PROTEINS DURING ENDOCYTOSIS AND EXOCYTOSIS. Natesan Ramakrishnan, Ryan P. Bradley, Richard Tourdot, Ravi Radhakrishnan 1582-P os B oard #B312 REAL-TIME MEASUREMENTS OF EXOCYTOSIS AND ENDOCYTOSIS IN C. ELEGANS NEURONS. Yongming Dong , B oard #B313 INTERACTION OF MUNC18C WITH SYNTAXIN4 AND THE ROLE OF MUNC18C IN EXOCYTOSIS. Czuee Morey , Dirk Fasshauer 1584-P os B oard #B314 IN VITRO PALMITOYLATION AND OXIDATION OF THE SNARE PROTEIN SNAP-25. Alex M. DaBell , Ryan Reynolds, David A. Gabrielsen, James R. Cardinal, Dixon J. Woodbury 1585-P os B oard #B315 education travel awardee THE C2B DOMAIN OF SYNAPTOTAGMIN-1 AND COMPLEXIN REDUCE THE ASYNCHRONOUS RELEASE ACTIVATION. Eduardo A. Quiroz-Manriquez , Ramón A. Jorquera 1586-P os B oard #B316 ISOFORM-SPECIFIC ROLES OF SYNAPTOTAGMINS IN EXOCYTOSIS. Tejeshwar Rao, Daniel R. Passmore, Edwin R. Chapman, Arun Anantharam 1587-P os B oard #B317 FRICTIONAL ADDITIVITY OF LATERAL DIFFUSION ON SUPPORTED BILAYERS: INFLUENCE OF LINKER LENGTH IN SYNAPTOTAGMIN 7 C2A-C2B TANDEM DOMAINS. Joseph K. Vasquez , Kan Chantranuvatana, Jefferson Knight 1588-P os B oard #B318 A NOVEL TARGET OF PROTEASOMAL DEGRADATION INDUCES HOMEOSTATIC PLASTICITY. Johnny J. Saldate , Victor A. Cazares, Arasakumar Subramani, Edward L. Stuenkel Jihong Bai 1583-P os

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Biophysical Society 58 th Annual Meeting, San Francisco, California