BPS Program Book 2014

1611-P os B oard #B341 ORAI3 DOMINANTLY MODULATES REDOX SENSITIVITY AND REQUIRES ORAI1 TO LOCALIZE TO MICRODOMAINS OF STORE-OPERATED ACTIVATION. Dalia Alansary, Ivan Bogeski, Barbara A. Niemeyer 1612-P os B oard #B342 ICRAC IN HUMAN PRIMARY PROSTATE EPITHELIAL CELLS. Christian Holzmann, Tatiana Kilch, Sven Kappel, Andrea Armbrüster, Volker Jung, Michael Stöckle, Ivan Bogeski, Eva C. Schwarz, Christine Peinelt 1613-P os B oard #B343 ACTIVATION OF STIM1 BY L-GLUTAMATE RAPIDLY INHIBITS L-TYPE CALCIUM CHANNEL CURRENT IN CULTURED HIPPOCAMPAL NEURONS. Philip J. Dittmer , Mark L. Dell’Acqua, William A. Sather 1614-P os B oard #B344 CHARACTERIZATION OF STORE-OPERATED CALCIUM CHANNELS IN PANCREATIC DUCT EPITHELIA. Jong Bae Seo , Mean-Hwan Kim, Bertil Hille, Duk-Su Koh 1615-P os B oard #B345 CHOLESTEROL REGULATES ORAI1 FUNCTION. Isabella Derler , Barbara Lackner, Marc Fahrner, Peter B. Stathopulos, Isaac Jardin, Judith Bergsmann, Mitsu Ikura, Christoph Romanin 1616-P os B oard #B346 ORAI AND TRPC CHANNEL CONTRIBUTION TO CALCIUM SIGNALING IN HUMAN MAST CELLS. Hannah Wajdner , Jasmine Farrington, Claire Barnard, Peter T. Peachell, Elizabeth P. Seward 1617-P os B oard #B347 UROTENSIN-II INDUCES VASCULAR SMOOTH MUSCLE CELL PROLIFERATION AND CREB PHOSPORYLATION THROUGH STORE OPERATED CALCIUM ENTRY AND EGFR TRANSACTIVATION. María Rodríguez-Moyano , Ignacio Díaz-Carrasco, Natalia Dionisio, Javier Ávila-Medina, Eva Calderón-Sánchez, Juan Antonio Rosado, Antonio Ordóñez-Fernández, Tarik Smani Calcium Fluxes, Sparks, and Waves I (Boards #B348–#B378) 1618-P os B oard #B348 EMERGENCE AND SYNCHRONIZATION OF THE “CALCIUM CLOCK” IN A 3-DIMENSIONAL MODEL OF A SINO-ATRIAL NODE CELL WITH EXPLICIT CHANNEL GATING. Michael Stern , Larissa A. Maltseva, Magdalena Juhaszova, Steven J. Sollott, Edward G. Lakatta, Victor A. Maltsev 1619-P os B oard #B349 SUPER-RESOLUTION MODELING OF CALCIUM RELEASE IN HEART. Mark A. Walker , George SB Williams, Tobias Kohl, Saleet Jafri, Stephan E. Lehnart, Joseph L. Greenstein, W J. Lederer, Raimond L. Winslow 1620-P os B oard #B350 ANTI-ARRHYTHMIC BLOCK OF RYR2 BY FLECAINIDE VERSUS PRO-ARRHYTHMIC BLOCK BY TETRACAINE IN A 3D MODEL OF A CARDIAC CELL. Derek R. Laver , Mark B. Cannell, Mohammad S. Imtiaz 1621-P os B oard #B351 ROLE OF THE INTER-RYR COUPLING IN CARDIAC INTRACELLULAR CALCIUM “CLOCK”. Alexander M. Ryvkin , Alexander S. Moskvin, Olga Solovyova, Vladimir S. Markhasin

1622-P os B oard #B352 FORMATION OF SUBCELLULAR CALCIUM WAVES IN CARDIAC MYOCYTES: CHARACTERIZING TIMESCALES VIA MATHEMATICAL MODELING. Michael Nivala , Christopher Ko, James Weiss, Zhilin Qu 1623-P os B oard #B353 SPATIAL IMPERFECTION ENCODES FUNCTIONAL PERFEC- TION: SUCCESS AND FAILURE OF CALCIUM RELEASE TO PROPAGATE REGULATE PACEMAKER CELL FUNCTION. Victor A. Maltsev , Anna V. Maltsev, Edward G. Lakatta, Michael D. Stern 1624-P os B oard #B354 CALCIUM SIGNALING IN MUSCLE CELLS FROM A PATIENT COHORT WITH INHERITABLE MUSCLE DISEASES. Lourdes Figueroa, Carlo Manno, Joshua N. Edwards, Jianxun Yi, Jingsong Zhou, Natalia Kraeva, Sheila Riazi, Eduardo Ríos 1625-P os B oard #B355 CA 2+ NANOSPARKS: JUNCTIONAL CA 2+ DYNAMICS PROBED WITH A NEW TARGETED BIOSENSOR. Wei Shang , Fujian Lu, Tao Sun, Jiejia Xu, Lin-lin Li, Yanru Wang, Liangyi Chen, Xianhua Wang, Mark B. Cannell, Shi-qiang Wang, Heping Cheng 1626-P os B oard #B356 ORIGIN OF ARRHYTHMOGENIC CA 2+ WAVE IN ATRIAL MYOCYTES UNDER FLUID PRESSURE: ROLE OF DENSE, DISORIENTED RYR CLUSTERS COUPLED WITH MEMBRANE INVAGINATION. Joon-Chul Kim, Min-Jeong Son, Sun-Hee Woo 1627-P os B oard #B357 NATURAL ALKALOID MURRAYAFOLINE-A SENSITIZES CA 2+ RELEASE SITES VIA ADENYLATE CYCLASE AND PROTEIN KINASE C PATHWAY IN RAT VENTRICULAR MYOCYTES. Joon-Chul Kim , Min-Jeong Son, Sun-Hee Woo 1628-P os B oard #B358 EXPLORING SR CALCIUM AND CYTOSOLIC CALCIUM WAVE DYNAMICS USING A 3D STOCHASTIC MYOCYTE MODEL. Tuan M. Hoang-Trong , William J. Lederer, Moshin S. Jafri 1629-P os B oard #B359 DYNAMICS OF CALCIUM SPARKS AND SR CALCIUM LEAK DURING EXCITATION-CONTRACTION COUPLING IN MOUSE HEART CELLS. George S. B. Williams , Andrew P. Wescott, W. J. Lederer, M. Saleet Jafri 1631-P os B oard #B361 INVESTIGATION OF ARRHYTHMOGENIC CALCIUM EVENTS BY INITIATING LOCAL CALCIUMRELEASE INCARDIOMYOCYTES. Brian M. Hagen , Joseph P.Y. Kao, W. Jonathan Lederer 1632-P os B oard #B362 THE ROLE OF JUNCTIONAL- AND NON-JUNCTIONAL CA RELEASE SITES IN THE GENERATION OF ABERRANT DIASTOLIC CA RELEASE IN MYOCYTES FROM POST- MYOCARDIAL INFARCTION HEARTS. Andriy E. Belevych , Cynthia A. Carnes, George E. Billman, Sandor Gyorke 1633-P os B oard #B363 ABLATION OF MAJOR PKA AND/OR CAMKII PHOSPHORYLATION SITES IN THE RYR2 CHANNEL DIFFERENTIALLY AFFECTS THE SUSCEPTIBILITY OF MICE TO VAGOTONIC ATRIAL FIBRILLATION. Roberto Ramos Mondragón , Emmanuel Camors, Patricia P. Powers, Héctor H. Valdivia ANKYRIN-B REDUCTION ENHANCES CALCIUM SPARKS VIA CAMKII. Samuel Galice, Sanda Despa 1630-P os B oard #B360

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Biophysical Society 58 th Annual Meeting, San Francisco, California