BPS2024 Full Program & Abstracts

1129-Pos Travel Award Winner HELIX 5 MEDIATES LIGAND-DEPENDENT FXR DYNAMICS. Riley Eisert Sasse , Tracy Yu, Denise Okafor 1130-Pos Board B83 ALLOSTERIC MODULATION OF THROMBIN BY THROMBOMODULIN: INSIGHTS FROM MACHINE LEARNING AND STATISTICAL ANALYSIS OF MOLECULAR DYNAMICS SIMULATIONS. Dizhou Wu , Freddie R. Salsbury 1131-Pos Board B84 MODULATION OF ALLOSTERY WITH MULTIPLE MECHANISMS BY HOTSPOT MUTATIONS IN TETR. Jiahua Deng , Yuchen Yuan, Qiang Cui 1132-Pos Board B85 TRACKING THE DYNAMICS OF THE CCT/TRIC COMPLEX AT THE SINGLE MOLECULE LEVEL. Kazutaka Araki , Takahiro Watanabe-Nakayama, Yuji C. Sasaki, Kazuhiro Mio 1133-Pos Board B86 A SIMPLE MUTATION-MINIMIZATION SCHEME ELUCIDATES THE FITNESS LANDSCAPE OF GB1 BINDING TO IGG-FC. Tandac Furkan Guclu , Ali Rana Atilgan, Canan Atilgan 1134-Pos Board B87 CROSS-TALK BETWEEN TOXIN DYNAMICS AND K + -CHANNEL BINDING: CONVERGING INSIGHTS FROM NMR AND MD SIMULATIONS. Chen Tim sit, Inbal Sher, Sai Chaitanya Chiliveri, Adriaan Bax, Ruiming Zhao, Steven Goldstein, Dan Major, Jordan H. Chill 1135-Pos Board B88 HIGH-THROUGHPUT SAMPLING OF PROTEIN DYNAMICS AT DIFFER ENT STAGES IN EVOLUTION. Michael Sauer , Souvik Mondal, Matthias Heyden 1136-Pos Board B89 CONFORMATIONAL ENTROPY IN PROTEIN STABILITY, MOLECULAR RECOGNITION AND ALLOSTERIC REGULATION. Josh Wand , Anthony C. Bishop, Jose Alfredo Caro, Taylor R. Cole, Sravya Kotaru, Mauricio Lasa gna, Rosana Lopes, Glorise Montalvo-Torres, Kelly Risch, Weimin Tan 1137-Pos Board B90 THERMODYNAMIC STABILITY AS A DETERMINANT OF THE P K A VALUES OF IONIZABLE RESIDUES IN HYDROPHOBIC ENVIRONMENTS IN PRO TEINS. Miranda N. Hurst , Bertrand Garcia-Moreno Membrane Protein Structures I (Boards B91 - B114) 1138-Pos Board B91 Travel Award Winner COMPUTATIONAL RECONSTRUCTION OF THE LDL-RECEPTOR-RELATED PROTEIN 1 (LRP1) ATOMISTIC STRUCTURE EVOLUTION FROM SUPER TERTIARY TO QUATERNARY. Gian Marco Tuveri , Silvia Acosta Gutierrez, Giancarlo Franzese, Lorena Ruiz Perez, Giuseppe Battaglia 1139-Pos Board B92 UNDERSTANDING THE MOLECULAR BASIS OF MUTATION-INDUCED DYSFUNCTION OF LYSOSOMAL MEMBRANE PROTEINS. Vikas Navratna , Arvind Kumar, Shyamal Mosalaganti 1140-Pos Board B93 STRUCTURAL MECHANISM OF MITOCHONDRIAL MEMBRANE REMOD ELING BY HUMAN OPA1. Halil Aydin 1141-Pos Board B94 STRUCTURAL UNDERSTANDING OF PURINE NUCLEOTIDE INHIBITION OF HUMAN UCP1 PROTEIN. Prerana Gogoi , Scott A. Jones, Jonathan J. Ruprecht, Martin S. King, Yang Lee, Thomas Zögg, Els Pardon, Deepak Chand, Stefan Steimle, Danielle M. Copeman, Camila A. Cotrim, Jan Steyaert, Paul G. Crichton, Edmund R.S. Kunji, Vera Moiseenkova-Bell Board B82

1142-Pos Board B95 STUDYING INTERACTION OF KCNE3 WITH KCNQ1 IN A LIPID BILAYER MEMBRANE USING MOLECULAR DYNAMICS SIMULATIONS. Indra D. Sahu , Antonio Javier F. Aguado, Anna Clara Miranda Moura, Isaac K. Asare, Steve Alston, Andrea N. Kravats, Charles R. Sanders, Gary A. Lorigan 1143-Pos Board B96 THE EFFECT OF THE INTERACTION IMPAIRING MUTATIONS ON THE STRUCTURAL AND DYNAMIC PROPERTIES OF KCNE3 USING EPR SPEC TROSCOPY. Draven B. Reynolds , Conner Campbell, Matthew Scheyer, Sebastian Fonseca, Zoe Warri, Beyza Bektasoglu, Puspa Sahu, Charles R. Sanders, Gary A. Lorigan, Indra D. Sahu 1144-Pos Board B97 STUDYING STRUCTURAL DYNAMIC PROPERTIES OF KCNE3 IN LIPID BILAYER MEMBRANE IN THE PRESENCE OF INTERACTION IMPAIRING MUTATIONS USING MOLECULAR DYNAMICS SIMULATIONS . Anna Clara Moura , Isaac K. Asare, Antonio J.F. Aguado, Kaeleigh D. Tuck, Mateo F. Cruz, Ikponwmosa Obaseki, Steve Alston, Andrea N. Kravats, Charles R. Sanders, Gary A. Lorigan, Indra D. Sahu 1145-Pos Board B98 STRUCTURAL DYNAMICS OF KCNE3 WHILE INTERACTING WITH KCNQ1- A SITE-DIRECTED SPIN LABELING EPR SPECTROSCOPIC STUDY. Conner Campbell , Draven B. Reynolds, Matthew Scheyer, Sebastian E. Fonseca, Patrick Williams, Zoe Warri, Alison Bates, Beyza Bektasoglu, Puspa Shah, Charles R. Sanders, Gary A. Lorigan, Indra D. Sahu 1146-Pos Board B99 IN SEARCH OF A COMPACT CLOSED CONFORMATION OF BACTERIAL MECHANOSENSITIVE CHANNEL MSCS. Elissa Moller , Madolyn Britt, Andriy Anishkin, Kenjiro Yoshimura, Fei Zhou, Doreen Matthies, Sergei Board B100 STRUCTURAL CHARACTERIAZATION OF MAGNESIUM TRANSLOCATION SYSTEMS IN PATHOGENIC BACTERIA. Patrick O’Reilly , Doreen Matthies 1148-Pos Board B101 CRYO-EM CHARACTERIZATION OF FULL-LENGTH INTEGRINAIIB BETA3. Hanwen Feng , Tong Huo, Hongjiang Wu, Zhao Wang 1149-Pos Board B102 EXPLORING ISOFORM VARIATIONS IN EPHA1 AND EPHA2 HOMO-DI MERIZATION: MOLECULAR DYNAMICS SIMULATION OF THEIR TRANS MEMBRANE AND MEMBRANE PROXIMAL REGIONS. Amita R. Sahoo 1150-Pos Board B103 STRUCTURAL MECHANISM OF TRPV5 INHIBITION BY ECONAZOLE. Jose Juan De Jesus-Perez , Edwin C. Fluck, Matthew Gabrielle, Sumiyya Ra heem, Tibor Rohacs, Vera Moiseenkova-Bell 1151-Pos Board B104 EXPANDING THE AMPHIPOL TOOLBOX FOR MEMBRANE PROTEIN RESEARCH. Korantin Le Mouël, Baptiste MICHON, Anaïs Marconnet, Manuela A. Zoonens 1152-Pos Board B105 Travel Award Winner THINK LIKE A CHANNEL, ACT LIKE A CARRIER. Valeria Kalienkova , Martin F. Peter, Jan Rheinberger, Cristina Paulino 1153-Pos Board B106 Travel Award Winner STRUCTURAL STUDIES OF CONNEXIN 32 GAP JUNCTION CHANNELS BY CRYO-EM. Ananth Prasad Burada , Jorge E. Contreras, Aravind Penmatsa 1154-Pos Board B107 STRUCTURAL IMPLICATIONS OF LIPID PROTEIN INTERACTIONS IN PRES TIN MEDIATED ELECTROMOTILITY. Navid Bavi , Patrick R. Haller, Eduardo Perozo Sukharev 1147-Pos

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