BPS2024 Full Program & Abstracts

Intrinsically Disordered Proteins II (Boards B121 - B144)

1155-Pos Board B108 IN SITU STRUCTURE AND MODEL OF THE NUCLEAR BASKET. Joshua Hutchings , Digvijay Singh, Farhaz Shaikh, Sergey Suslov, Elizabeth Villa 1156-Pos Board B109 THE SUBSTRATE AND INHIBITOR BINDING MECHANISM OF POLYSPECIF IC TRANSPORTER OAT1 REVEALED BY HIGH-RESOLUTION CRYO-EM. Ton gyi Dou , Tengfei Lian, Shi Shu, Yi He, Jiansen Jiang 1157-Pos Board B110 DETERMINING NATIVE-LIKE MEMBRANE PROTEIN STRUCTURES FROM CELL MEMBRANE-DERIVED VESICLES. Xiao Tao, Chen Zhao , Roderick MacKinnon 1158-Pos Board B111 UNRAVELLING BCL-2 PROTEINS´MEMBRANE-MEDIATED FUNCTIONING IN MITOCHONDRIAL APOPTOSIS. Tamas Milan Nagy, Sophie Ayscough, Jörgen Åden , Tobias Sparrman, Hanna Wacklin-Knecht, Luke A. Clifton, Gerhard Grobner 1159-Pos Board B112 CRYO-EM STRUCTURE OF SYNAPTIC VESICLE PROTEIN 2B. Matthew F. Martin , Anshumali Mittal, Jonathan Coleman 1160-Pos Board B113 QUANTITATIVE ANALYSIS OF STEROL MODULATED MONOMER-DIMER EQUILIBRIUM OF ß 1 -ADRENERGIC RECEPTOR BY DEER SPECTROSCO PY. Nina Kubatova , Thomas Schmidt, G. Marius Clore 1161-Pos Board B114 MOLECULAR DETERMINANTS OF ARRESTIN BINDING TO DIMERIC GP CRS. Dagan C. Marx , Joon Lee, Alexa Strauss, Kevin Huynh, David Eliezer, Josh Levitz Membrane Protein Folding (Boards B115 - B120) 1162-Pos Board B115 Travel Award Winner MOLECULAR DYNAMICS SIMULATIONS TO INVESTIGATE PROTEIN FOLD ING OF CROSS-SEEDED TAU AND AMYLIN IN ALZHEIMER’S DISEASE. Na talia Santos , Luthary Segura, Kwan Hon K. Cheng 1163-Pos Board B116 DEVELOPMENT OF THE METHOD FOR RECONSTITUTION OF BETA BARREL NANOPORE PROTEIN INTO CELL-SIZED LIPOSOME. Toshiyuki Tosaka , Koki Kamiya 1164-Pos Board B117 FKPA ENHANCES OUTER MEMBRANE PROTEIN FOLDING USING AN EX TENSIVE INTERACTION INTERFACE. Taylor A. Devlin , Dagan C. Marx, An neliese Faustino, Michaela Roskopf, Stephen D. Fried, Karen G. Fleming 1165-Pos Board B118 DISSECTING THE MECHANISTIC EVENTS IN ATP-DEPENDENT DEGRADA TION OF MEMBRANE PROTEINS MEDIATED BY THE AAA+ PROTEASE FTSH. Manoj Rana , Changwon Kim, Mihiravi Gunasekara, Saba Kanwal, Tae-Young Yoon, Heedeok Hong 1166-Pos Board B119 HYDROGEN BOND STABILIZES LIPID-ACCESSIBLE POLAR RESIDUES IN MEMBRANE PROTEINS. Lucas Shen , Karen G. Fleming 1167-Pos Board B120 BINDING AFFINITY AND SPECIFICITY OF OPACITY-ASSOCIATED PROTEINS AND HUMAN CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULES. Connor McDermott , Meagan Belcher Dufrisne, Linda M. Columbus

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1168-Pos Board B121 UNDER THE MICROSCOPE: A STRUCTURAL AND MECHANISTIC EXAMI NATION OF NOVEL TAU-TARGETED SMALL MOLECULE AGGREGATION INHIBITORS. Ellie I. James , Miklos Guttman, Abhinav Nath 1169-Pos Board B122 INTERACTIONS BETWEEN RPS3 AND NFΚB PLAY A ROLE IN REGULATING TRANSCRIPTION. Anthony Y. Cai , Elizabeth A. Komives 1170-Pos Board B123 MEASURING THE EFFECTS OF INFECTION ON DISORDERED VIRAL PRO TEINS. Patrick S. Koenig , Shahar Sukenik 1171-Pos Board B124 LOCKING IT IN: CAPTURING TRANSIENT INTERACTIONS OF NFΚB’S INTRINSICALLY DISORDERED TRANSCRIPTION ACTIVATION DOMAIN WITH AN UNNATURAL AMINO ACID CROSSLINKER. Tristan R. Gunther , Hannah E.R. Baughman, Huishan Chen, Elizabeth A. Komives 1172-Pos Board B125 USING THIOCYANATE PROBES TO EXAMINE THE MEMBRANE-BOUND STRUCTURES OF ALPHA-SYNUCLEIN. Melanie R. Stark , Tala Qaraqe, Abby Ryan, Vera Shattuck, Perla Villegas Minyety, Casey H. Londergan 1173-Pos Board B126 CAPTURING THE CONFORMATIONAL HETEROGENEITY OF THE Β-AMYLOID PEPTIDE SEQUENCE USING THE ENGINEERED AEROLYSIN CONFINEMENT. Hongyan Niu , Yan Gao, Meng-Yin Li, Yi-Lun Ying, Yi-Tao Long 1174-Pos Board B127 STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF N-TERMINALLY ACETYLATED A-SYNUCLEIN. Emily A.E. Brackhahn 1175-Pos Board B128 P53-TAD ACCESSES A SECOND POCKET IN MDM2 AND MDMX FOR TIGHTER BINDING. Guy W. Dayhoff III , Pirada S. Higbee, Asokan Anban adam, Sameer Varma, Gary W. Daughdrill 1176-Pos Board B129 ENABLING STRUCTURAL EVOLUTION OF INTRINSICALLY DISORDERED PROTEINS USING PULSED DIPOLAR ESR SPECTROSCOPY. Karen Tsay, Tim othy Keller, Yann Fichou, Jack H. Freed, Songi Han, Madhur Srivastava 1177-Pos Board B130 THE PROPERTIES OF ELASTIC PROTEIN MATERIALS ARE DIRECTED BY THE PROPERTIES OF THEIR DISORDERED MONOMERIC PRECURSORS. Ronald Koder , Jonathan Preston, James Aramini, Ma. Faye Charmagne Carvajal, Giovanni Crump, Richard Wittebort 1178-Pos Board B131 TUNABLE SINGLE-MOLECULE DNA MECHANICS DETERMINES THE VIS COELASTICITY OF CHROMATIN CONDENSATES. Ritika Gupta , Ibraheem Alshareedah, Taranpreet Kaur, Priya R. Banerjee 1179-Pos Board B132 CONFORMATIONAL ENTROPY OF INTRINSICALLY DISORDERED PROTEINS BARS INTRUDERS FROM BIOMOLECULAR CONDENSATES. Vladimir Grigorev , Yaojun Zhang, Ned S. Wingreen 1180-Pos Board B133 REVERSING ABERRANT PHASE TRANSITIONS OF ALS-LINKED DISEASE PROTEIN FUS WITH RNA. Jenny L. Carey , Emma Robinson, James Shorter, Lin Guo

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