BPS2024 Full Program & Abstracts

1418-Pos Board B371 NAADP-EVOKED SODIUM CURRENTS OF TWO-PORE CHANNELS MEDI ATED BY LSM12 AND PI(3,5)P 2 . Xin Guan , Canwei Du, Kunal R. Shah, Guanxing Chen, Jiusheng Yan 1419-Pos Board B372 CALCIUM- AND PTK-DEPENDENT SUPPRESSION OF MACROSCOPIC HOMOMERIC KV1.1, KV1.2 AND HETEROMERIC KV1.1/1.2 CURRENTS BY AΒ(1-42) PEPTIDE: IMPLICATIONS FOR ALZHEIMER’S DISEASE. Joseph Farley , Dina Jamshidi 1420-Pos Board B373 MODULATION OF KCNQ1/KCNE CHANNEL COMPLEXES BY INTRACELLU LAR ZINC. Shuo Zhang, Xinhe Yang, Sai Shi, Haixia Gao, Nikita Gamper 1421-Pos Board B374 MEMBRANE LIPIDS IN ALLOSTERIC GATING OF THE SLO1 BK CHAN NEL. Toshinori Hoshi , Stefan H. Heinemann, Yutao Tian 1422-Pos Board B375 MD SIMULATION IDENTIFIES A NOVEL AND DIRECT MECHANISM FOR PIP2 ACTIVATION OF SK2. Ryan L. Woltz , Woori Choi, Khoa Ngo, Brandon J. Harris, Yanxiao Han, Kyle Rouen, Pauline Trinh, Ebenezer N. Yamoah, Diego Lopez Mateos, Vladimir Yarov-Yarovoy, Igor V. Vorobyov, Xiao-Dong Zhang 10 , Nipavan Chiamvimonvat 11 1423-Pos Board B376 Travel Award Winner SERINE 474 RESIDUE REGULATES THE TRAFFICKING AND ACTIVITY OF KV3.1B CHANNEL. Diego Maureira , Denise Riquelme, Elías Leiva-Salce do, Oscar Cerda 1424-Pos Board B377 USING MOLECULAR DYNAMICS SIMULATIONS TO INVESTIGATE TME M16A ION CONDUCTANCE. Christina A. Stephens , Michael Grabe 1425-Pos Board B378 THE PIEZO1 CHANNEL INTERACTS WITH THE TRANSMEMBRANE CHAN NEL TMC1 TO EXERT MECHANOELECTRICAL TRANSDUCER (MET) FUNC TIONS. Pauline Trinh , Seojin Park, Jeong Han Lee, Maria C. Perez-Flores, Xiao-Dong Zhang, Nipavan Chiamvimonvat, Ebenezer N. Yamoah 1426-Pos Board B379 THE N-TERMINUS IS NOT THE CA 2+ -REGULATED GATE IN CALHM1 CHAN NELS. Zhongming Ma , Usha Paudel, J. Kevin Foskett 1427-Pos Board B380 AKAPS CONTRIBUTE TO THE INDIRECT PATHWAY FOR REGULATION OF CA V 1.2 CHANNELS BY RAD AND PKA. Lipeng Wang , Tamer M. Gamal El-Din, William A. Catterall 1428-Pos Board B381 DEXH-BOX HELICASE 9 (DHX9) IS A NOVEL SARAF INTERACTOR AND STORE OPERATED CALCIUM ENTRY (SOCE) REGULATOR. Joaquin Lopez , Pablo Cruz Nunez, Camila Benavides, Diego Maureira, Rodrigo Santos, Ian Silva, Oscar Cerda 1429-Pos Board B382 KCTD5 IS A NOVEL REGULATOR OF STORE OPERATED CALCIUM ENTRY VIA SARAF UBIQUITINATION. Pablo I. Cruz Nunez , Diego Maureira, Ian Silva, Joaquin Lopez, Hans J. Moldenhauer, Boris J. Lavanderos, Rosario Ibañez, Rodrigo Santos, Oscar Cerda 1430-Pos Board B383 DEFINING THE BINDING SITE FOR SINGLE ACYL CHAIN LIPIDS ON ASIC3. Rebecca Roth , Ramya Bandarupalli, Robert C. Klipp, Jing Li, John R. Bankston 1431-Pos Board B384 ENGINEERING INTRACELLULAR MODULATORS FOR TUNING THE SODIUM-LEAK CHANNEL NALCN. Allen L. Hsu , Manu Ben-Johny

1432-Pos Board B385 OPENING ENERGETICS OF A POLYCYSTIN CHANNEL. Leo Ng, Megan Larmore, Brandon J. Harris, Vladimir Yarov-Yarovoy, Paul G. DeCaen 1433-Pos Board B386 SPHINGOSINE-1-PHOSPHATE ACTIVATES VOLUME-REGULATED ANION CHANNELS THROUGH GΒΓ DIMERS. Iuliia Kostritskaia , Tobias Stauber 1434-Pos Board B387 THE NONLINEAR CONCENTRATION SCALING OF OMPF CHANNEL GAT ING. Maria Queralt-Martin , Deborah Aurora Perini, Laidy Maidel Alvero González, Antonio Alcaraz 1435-Pos Board B388 THE C-TERMINAL ACTIVATING DOMAIN PRIMES THE PANX1 CHANNEL BY REPOSITIONING THE N-TERMINUS. Jacqueline Ehrlich , Toshimitsu Kawate 1436-Pos Board B389 LIGAND-INDUCED CLUSTERING OF COPPER TRANSPORTER CTR1 ALTERS PLASMA MEMBRANE PROPERTIES TO REGULATE ITS ENDOCYTO SIS. Subhendu K. Chatterjee, Sumanta Kar, Tanmoy Ghosh, Bidisha Sinha, Arnab Gupta 1437-Pos Board B390 CRYO-EM STRUCTURES OF HUMAN MAGNESIUM CHANNEL MRS2 REVEAL GATING AND REGULATORY MECHANISMS. Louis Tung Faat Lai , Jayashree Balaraman, Fei Zhou, Doreen Matthies 1438-Pos Board B391 ELUCIDATING ION CONFIGURATIONS AND WATER DYNAMICS IN A K + ION CHANNEL USING TWO-DIMENSIONAL INFRARED SPECTROSCO PY. Alexei Kananenka , Matthew Ryan, Lujia Gao, Francis I. Valiyaveetil, Martin T. Zanni 1439-Pos Board B392 USING PHOTOLIPIDS TO TRIGGER CHANNEL ACTIVITY BY LIGHT. Rohit Yadav, Jürgen Pfeffermann, Nikolaus Gössweiner-Mohr, Peter Pohl 1440-Pos Board B393 ENGINEERING AN OFF-SWITCH FOR BACKGROUND TREK1 POTASSIUM CHANNELS. Elena B. Riel , Louis Goldberg, Paul M. Riegelhaupt 1441-Pos Board B394 CRYO-ELECTRON MICROSCOPY STRUCTURE OF HUMAN KIR2.1 POTAS SIUM CHANNEL BOUND TO THE ACTIVATOR PIP 2 REVEALS ITS GATING MECHANISM. Carlos A.H. Fernandes , Dania Zuniga, Rafael F. Veloso, Andreas Zoumpoulakis, Renaud Wagner, Catherine Venien-Bryan 1442-Pos Board B395 CRYO-EM STRUCTURES OF K CA 2.2 CHANNELS REVEAL THE CONFORMA TIONAL CHANGES IN THE SELECTIVITY FILTER INDUCED BY AN INHIBI TOR. Young-Woo Nam, Mario Tringides, Dohyun Im, Hai M. Nguyen, Yan Liu, Chih-Chia Su, Meng Cui, Heike Wulff, Edward W. Yu, Miao Zhang 1443-Pos Board B396 IMPACT OF S1 HYDROPHOBIC RESIDUES ON VOLTAGE SENSING. Vam seedhar Rayaprolu, Heini Miettinen-Granger, William Baker, Matthew Fisher, Gwendolyn Mueller, William O. Rankin, J. Jack Kelly, William J. Ratzan, Lee Min Leong, Joshua A. Davisson, Bradley J. Baker, Susy C. Kohout 1444-Pos Board B397 ACTIVATION OF THE PROTON CHANNEL OTOP1 BY AMMONIUM CHLO RIDE AS A MECHANISM FOR TASTE TRANSDUCTION. Ziyu Liang , Emily R. Liman

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