BPS2024 Full Program & Abstracts

1493-Pos Travel Award Winner CHARACTERIZATION OF LV FUNCTION USING MYOCARDIAL STRAIN ANALYSIS IN CARDIAC TNC-A8V MOUSE MODEL. Paula Nieto Morales , Amanda M. Mascarenhas, Michael O. Assibey, Andrew P. Landstrom, Prescott B. Chase, Vitold E. Galkin, Stephen P. Chelko, J. Renato D. Pinto 1494-Pos Board B447 ENHANCING SARCOMERE FUNCTION AND LENGTH-DEPENDENT ACTIVATION IN ENGINEERED HUMAN MYOCARDIUM VIA TRIIODOTHY RONINE AND DEXAMETHASONE TREATMENT. Maicon Landim-Vieira , Adrian G. Cadar, Lili Wang, Bjorn C. Knollmann, J. Renato D. Pinto 1495-Pos Board B448 UMBRELLA SAMPLING SIMULATIONS OF CARDIAC THIN FILAMENT RE VEAL THERMODYNAMIC CONSEQUENCES OF TROPONIN I INHIBITORY PEPTIDE MUTATIONS. Steffen Lindert Smooth Muscle Mechanics, Structure, and Regulation (Boards B449 - B452) 1496-Pos Board B449 FUNCTIONAL ANALYSIS OF ZEBRAFISH P63RHOGEF-LIKE PROTEIN AIMING IDENTIFICATION OF ITS INHIBITOR USING ZEBRAFISH AS A MODEL. Kumiko Sakai , Akane Watanabe, Masaya Hirota, Natsuho Mori yama, Satoru Yamamoto, Ryosuke Wakabayashi, Kyoshiro Tsuge, Akira Shimamoto, Ko Momotani 1497-Pos Board B450 HUMAN MYOCARDIUM WITH ATTR AMYLOIDOSIS EXHIBITS INCREASED FIBROSIS, AMYLOID LOCALIZED MICROCALCIFICATIONS, AND DOWN REGULATED Z-DISC PROTEINS WITH NO CHANGE IN TITIN ISOFORM RA TIOS. Gregory Milburn , Andrew Yackzan, Austin G. Wellette-Hunsucker, Jania Bell, Utku Gulbulak, Kenneth S. Campbell 1498-Pos Board B451 FAILING HUMAN VENTRICULAR CARDIOMYOCYTES: A REEVALUATION OF CA 2+ CYCLING, VOLTAGE DEPENDENCE, AND SPARK CHARACTERIS TICS. Aman Ullah , Jerome Anthony E. Alvarez, Mohsin S. Jafri 1499-Pos Board B452 H-CALDESMON ALTERS THE MECHANICAL INTERACTIONS BETWEEN PHOS- AND UNPHOSPHORYLATED SMOOTH MUSCLE MYOSIN. Matheus L.C. Schultz , Andy Bai, Linda Kachmar, Anne-Marie Lauzon Microtubules, Structure, Dynamics, and Associated Proteins (Boards B453 - B474) 1500-Pos Board B453 TUBULIN FUNCTIONS IN EARLY DEVELOPMENT PROBED BY SINGLE ISOTYPE CRISPR-CAS9 KNOCKOUTS. Amir Sams , Tyler Bruno, Jeffrey M. Moore, Benjamin Feldman, Dan L. Sackett 1501-Pos Board B454 Travel Award Winner Γ-TUBULIN ORCHESTRATES EARLY EVENTS IN MITOSIS THAT STABILIZE NASCENT BIPOLAR SPINDLES. Shannon Sim , Colten Peters, Angela Zhao, Jackie Vogel 1502-Pos Board B455 UNDERSTANDING MICROTUBULE NUCLEATION THROUGH THE CON FORMATIONAL DYNAMICS OF Α, Β, AND Γ-TUBULINS. Kenneth Tsui 1503-Pos Board B456 Travel Award Winner BOTTOM-UP COARSE-GRAINED MODEL OF MICROTUBULE DYNAMICS: A BRIDGE BETWEEN LENGTH- AND TIMESCALES. Tomasz Skóra , Daniel Beckett, Tamara C. Bidone Board B446

1504-Pos Board B457 QUANTITATIVE CHARACTERIZATION OF STEADY STATES FOR SYSTEMS OF MICROTUBULES: A STOCHASTIC AGENT-BASED MODELING AP PROACH. Sayandeepa Raha 1505-Pos Board B458 ALL THINGS ALLOSTERY: CHARACTERIZING THE ALLOSTERIC CONTROL OF THE CONFORMATIONAL TRANSITION OF THE SPASTIN SEVERING MOTOR. Amanda C. Macke , Carter St.Clair, Shehani D. Kahawatte, Maria S. Kelly, Ruxandra I. Dima 1506-Pos Board B459 PROBING ALLOSTERIC NETWORK PERTURBATIONS IN SPASTIN DUE TO A HEREDITARY SPASTIC PARAPLEGIA MUTATION. Shehani Kahawatte , Amanda C. Macke, Ruxandra I. Dima 1507-Pos Board B460 TUBULIN C-TERMINAL TAILS SHOW DISTINCT PATTERNS OF SELF-INTER ACTION. Patrick DeLear , David Sept 1508-Pos Board B461 OPTIMIZING BIOPHYSICAL PREDICTOR SELECTION FOR KATANIN AL LOSTERIC TRANSITIONS VIA METADYNAMICS AND MACHINE LEARN ING. Maria S. Kelly , Riccardo Capelli, Shehani Kahawatte, Hesaree Wijethunga, Paolo Carloni, Ruxandra I. Dima 1509-Pos Board B462 EFFECTS OF DIFFERENT PRC1 CONSTRUCTS ON MICROTUBULE ASSEM BLY AND SELF-ORGANIZATION. Julia F. Bourdeau , Ariana Martin, Imara Davis, Prashali Chauhan, Jennifer L. Ross 1510-Pos Board B463 Travel Award Winner DISSECTING THE FUNCTION OF THE MICROTUBULE-ASSOCIATED PRO TEIN, DOUBLECORTIN. Regina L. Agulto , Kassandra M. Ori-McKenney 1511-Pos Board B464 RECOGNITION OF THE NUCLEOTIDE-DEPENDENT FEATURE FACILITATES THE MICROTUBULE END-BINDING OF MCAK. Wei Chen , Xin Liang 1512-Pos Board B465 CONSTRUCTING A LIBRARY OF E-HOOK PEPTIDE STRUCTURES TO AID IN DECIPHERING THE TUBULIN CODE. Alexander Bromley , Nathan I. Ham mer, Ryan C. Fortenberry, Dana N. Reinemann 1513-Pos Board B466 TAU PHOSPHORYLATION RESULTS IN MORE DIFFUSIVE INTERACTIONS WITH MICROTUBULES AND PERTURBS ORGANELLE TRAFFICKING IN NEURONS. Daniel Beaudet , Karthikeyan Swaminathan, Adam G. Hen dricks 1514-Pos Board B467 MAPPING THE MECHANICAL PROPERTIES OF TAU’S POLYELECTROLYTE BRUSH USING ATOMIC FORCE MICROSCOPY. Aanzan Sachdeva , Zachary J. Donhauser 1515-Pos Board B468 CHARACTERIZING SURFACE-BOUND TAU ISOFORMS USING ATOMIC FORCE MICROSCOPY. Lukas R. Johnson , Zachary J. Donhauser 1516-Pos Board B469 REPRODUCIBILITY OF ATOMIC FORCE MICROSCOPY MEASUREMENTS ON TAU PROTEIN. Shira M. Freilich , Isabella Sagman, Zachary J. Don hauser 1517-Pos Board B470 ESTIMATION OF MICROTUBULE-GENERATED FORCES COMBINING MOLECULAR DYNAMICS AND COARSE-GRAINED MODELING. Maksim Kalutskii , Helmut Grubmüller, Maxim Igaev

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