BPS2024 Full Program & Abstracts

Registration/Information 7:30 am - 5:00 pm, Registration Bridge West Biophysical Society Business Meeting 8:00 am - 9:00 am, Room 111AB Poster Viewing 8:00 am - 4:00 pm, Exhibit Hall AB Symposium New Insights into Ion Channel Regulation 8:15 am - 10:15 am, Ballroom A

1654-Symp 9:50 am FUNCTIONAL PARTITIONING OF TRANSCRIPTIONAL REGULATORS BY PATTERNED CHARGE BLOCKS AND OTHER IDR SEQUENCE FEATURES. Benjamin Sabari Platform Computational Methods and Machine Learning, Artificial Intelligence, and Bioinformatics II 8:15 am - 10:15 am, Room 103AB Co-Chairs Emmanuel Asante-Asamani, Clarkson University, USA Yu-Shan Lin, Tufts University, USA 1655-Plat 8:15 am OPTIMIZING HIGH-THROUGHPUT BINDING FREE ENERGY SIMULATIONS FOR SMALL MOLECULE DRUG DISCOVERY. S. Benjamin Koby , Evgeny Gutkin, Filipp Gusev, Christopher Kottke, Shree Patel, Olexandr Isayev, Maria G. Kurnikova 1656-Plat 8:30 am STRUCTURE PREDICTION OF CYCLIC PEPTIDES VIA MOLECULAR DYNAM ICS AND MACHINE LEARNING. Yu-Shan Lin 1657-Plat 8:45 am ENHANCED CONFORMATIONAL SPACE EXPLORATION FOR BIOMOLE CULES USING DENOISING DIFFUSION PROBABILISTIC MODELS. Zakarya Benayad , Guillaume Stirnemann 1658-Plat 9:00 am TOWARDS A SYSTEMATIC MODELLING APPROACH FOR COARSE GRAINED CARBOHYDRATES. Astrid F. Brandner , Paulo Cesar T. Souza, Siewert J. Marrink, Syma Khalid 1659-Plat 9:15 am QUANTIFYING BRISTLE CELL ORGANIZATION IN DROSOPHILA MELA NOGASTER. Audrey Neighmond, Wisdom Attipoe, Ginger Hunter, Em manuel O. Asante-Asamani 1660-Plat 9:30 am OPENNUCLEOME FOR HIGH RESOLUTION NUCLEAR STRUCTURAL AND DYNAMICAL MODELING. Zhuohan Lao , Bin Zhang 1661-Plat 9:45 am HOW ACCURATE ARE DRUG BINDING POSE PREDICTIONS USING ALPHA FOLD MODELS? Masha Karelina , Joseph J. Noh, Ron O. Dror 1662-FlashTalk 10:00 am A NEAR-CONTINUUM MODEL OF MORPHODYNAMIC SINGLE-CELL STATES QUANTIFYING GENE EXPRESSION DURING EPITHELIAL-MESEN CHYMALTRANSITIONS. Jalim Singh , Jeremy T. Copperman, Ian McLean, Laura M. Heiser, Daniel M. Zuckerman 1663-FlashTalk 10:05 am ACCURATE PROTEIN FITTING INTO CRYO-EM MAPS USING MULTIPLE CONFORMERS GENERATED BY ALPHAFOLD2. Tatiana Shugaeva , nandan haloi, Rebecca J. Howard, Erik R. Lindahl 1664-FlashTalk 10:10 am DOCKING FOR MOLECULES THAT BIND IN A SYMMETRIC STACK TO ALZHEIMER’S DISEASE TAU FIBRILS WITH SYMDOCK. Matthew S. Smith , Peter Kunach, Ian S. Knight, Rian Kormos, Joseph G. Pepe, Isabella Glenn, John J. Irwin, William F. DeGrado, Marc I. Diamond, Sarah H. Shahmoradian, Brian K. Shoichet

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Co-chairs Anna Bukiya, University of Tennessee Health Science Center, USA Avia Rosenhouse-Dantsker, University of Illinois at Chicago, USA 1647-Symp 8:15 am MODULATION OF TRPV1 AND TRPV4 CHANNELS BY GLYCEROPHOSPHO LIPIDS. Tamara Rosenbaum – IUPAB Sponsored Speaker 1648-Symp 8:40 am CHOLESTEROL MODULATES PIP2 LEVELS/LOCALIZATION FOR MAINTAIN ING CELLULAR LIPID HOMEOSTASIS. Kailash Gulshan 1649-Symp 9:05 am BK CHANNEL REGULATION BY CHOLESTEROL: DIFFERENT SUBUNITS, DIFFERENT MECHANISMS. Anna Bukiya 1650-SympSelect 9:30 am MAGNESIUM TRANSPORTER MGTA REVEALED AS A DIMERIC P-TYPE ATPASE. Rilee Zeinert, Fei Zhou, Pedro Franco, Jonathan Zöller, Henry J. Lessen, Zaid K. Madni, Aravind Iyer, Julian Langer, Alexander J. Sodt, Gisela Storz, Doreen Matthies 1651-Symp 9:50 am INSIGHTS INTO ION CHANNEL MODULATION BY LIPIDS: A FOCUS ON CHOLESTEROL AND PI(4,5)P 2 . Avia Rosenhouse-Dantsker Symposium Intrinsically Disordered Regions in Transcriptional Regulation 8:15 am - 10:15 am, Ballroom B Chair Benjamin Sabari, University of Texas Southwestern Medical Center, USA No Abstract 8:15 am TRANSCRIPTIONAL CONDENSATES IN HEALTH AND DISEASE. Denes Hnisz No Abstract 8:40 am A ROLE FOR INTRINSICALLY DISORDERS REGIONS IN DIRECTING TRAN SCRIPTION FACTORS TO THEIR GENOMIC BINDING SITES. Naama Barkai 1652-Symp 9:05 am TOPOLOGICAL FORMATION OF TRANSCRIPTIONAL CONDENSATES RELA TIVE TO SUBNUCLEAR COMPARTMENTS. Wonki Cho 1653-SympSelect 9:30 am THE IN-CELL LIQUID-LIKE STATE OF THE NUCLEAR PORE COMPLEX PERMEABILITY BARRIER. Miao Yu, Maziar Heidari, Gerhard Hummer, Edward A. Lemke

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