BPS2024 Full Program & Abstracts

Protein-Small Molecule Interactions I (Boards B28 - B50)

1893-Pos Board B42 ANALYSIS OF FLUOROPHORES FOR PEPTIDE SUBSTRATES USED IN INFLAMMATORY CASPASE ACTIVITY ASSAYS. Rachel C. Cordero , Zharia Brandon, Jelani Shadd, Phasu Sirinit, Kaitlyn Shelley, Sophie Young, Cath rine A. Southern, Caitlin Karver 1894-Pos Board B43 OPEN-COMBIND: HARNESSING UNLABELED DATA FOR IMPROVED BIND ING POSE PREDICTION. Andrew T. McNutt , David R. Koes 1895-Pos Board B44 LIQUID-LIQUID PHASE SEPARATION INDUCED BY INTERACTIONS BETWEEN THE PICORNAVIRUS 3C(D) MAIN PROTEASE AND GENOMIC RNA CONTROL ELEMENTS. Somnath Mondal , Kevin E.W. Namitz, Neela Yennawar, David D. Boehr 1896-Pos Board B45 IDENTIFYING AND CHARACTERIZING HYDROPHILIC PROTEIN SURFACE PATCHES WITH MOLECULAR DYNAMICS SIMULATIONS. Lilia F. Escobe do , Nicholas B. Rego, Daeyeon Lee, Amish J. Patel 1897-Pos Board B46 STRUCTURAL INSIGHTS INTO TARGETED DEGRADATION OF CASEIN KI NASE 1-Α. Sarah Young , Gisele Nishiguchi, Sherif Abdelhamed, Elizabeth Caine, Lauren Mascibroda, Jeffrey Kooijman, Darcie Miller, Kevin Mc Gowan, Anand Mayasundari, Zhe Shi, Anup Aggarwal, Marcus Fischer, Jeffery Klco, Zoran Rankovic 1898-Pos Board B47 BINDING SMALL MOLECULE DRUGS MAY AVOID PROTEIN MISFOLDING INTO NON-COVALENT LASSO ENTANGLEMENTS. Yang Jiang , Edward P. O’Brien 1899-Pos Board B48 Canceled MOLECULAR INSIGHTS INTO THE NEUROPROTECTIVE EFFECTS OF CHLOROGENIC ACIDS MEDIATED BY THE PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR PPARALPHA. Mercedes Alfonso Prieto , Nicolas P.F. Mueller, Olga A. Sergeeva, Luciano Navarini, Paolo Carloni 1900-Pos Board B49 Travel Award Winner TRANSLATIONAL TAKEDOWN: CYFIP1-BASED PEPTIDOMIMETIC AGAINST CANCER AND FRAGILE X SYNDROME. Alice Romagnoli , Stefano Raniolo, Alessandro Gori, Anastasia De Luca, Vittorio Limongelli, Daniele Board B50 SMALL MOLECULE ALLOSTERIC MODULATORS OF THE AML-ASSOCIATED SRC-FAMILY KINASE, HCK. Ari M. Selzer , Gabriella J. Gerlach, Giancarlo Gonzalez-Areizaga, Thomas E. Wales, Carlos J. Camacho, Rieko Ishima, John R. Engen, Thomas E. Smithgall Protein Assemblies I (Boards B51 - B68) 1902-Pos Board B51 EXPLORING DORA: INVESTIGATING THE ASSEMBLY OF DORYTEUTHIS OPALESCEN REFLECTIN PROTEINS. Sam W. Marchant , Galia T. Debe louchina 1903-Pos Board B52 STRUCTURE AND ACTIVATION OF THE HUMAN AUTOPHAGY-INITIATING ULK1C:PI3KC3-C1 SUPERCOMPLEX. Minghao Chen , Xuefeng Ren, Annan S.I. Cook, James H. Hurley 1904-Pos Board B53 COARSE-GRAINED (CG) SIMULATIONS OF HIV MATURATION WITHIN VIRAL PARTICLES. Anahita Khammari , Hanyu Song, Ethan Wang, Sinai Lee, Alvin Yu Di Marino 1901-Pos

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1879-Pos Board B28 ALLOSTERIC RESTRICTION ENHANCES SENSITIVITY OF THE AML-ASSOCI ATED SRC-FAMILY KINASE FGR TO ATP-SITE INHIBITORS. Giancarlo Gon zalez-Areizaga , John J. Alvarado, Du Shoucheng, Thomas E. Smithgall 1880-Pos Board B29 KU124 AS A NOVEL TASK-1 INHIBITOR. Joana Lopez , Diego Chavez, Abena Amankwaa, Steven Almazan, Annette Jacob, Justin Patino, David Graham, Megan Blaisdell, Jenna Marciano, Rhustie Valdizno, Nikki Mastrodomenico, Jonelle Brown, Chelsea Pelley, Ana Dumani, Thomas W. Comollo 1881-Pos Board B30 KINETICS OF IMIDAZOLE DERIVATIVES BINDING TO CYTOCHROME C. Oleksandr Kokhan , Zahra Moradi 1882-Pos Board B31 A NOVEL HIGH THROUGHPUT SCREENING ASSAY TO DISCOVER BACTE RIAL DNA GYRASE POISONS. Matthew Dias 1883-Pos Board B32 THE STRUCTURAL BASIS FOR 2’-5’/3’-5’-CGAMP SYNTHESIS BY CGAS. Sh uai Wu , Sandra Gabelli, Jungsan Sohn 1884-Pos Board B33 SMALL MOLECULES RESCUE DESMOPLAKIN DEGRADATION. Madeleine Benes , Roujon A. Nowzari, Clay P. Page, Nathan T. Wright 1885-Pos Board B34 Travel Award Winner STRUCTURAL INSIGHTS INTO A NEW CLASS OF NONCOVALENT, POTENT, AND HIGHLY SELECTIVE G PROTEIN-COUPLED RECEPTOR KINASE 5 INHIBITORS. Yueyi Chen 1886-Pos Board B35 REGULATION OF ATP AFFINITY TO THE BACTERIAL CHEMOTAXIS KINASE CHEA. Katherine Wahlbeck , Jasna Fejzo, Lynmarie K. Thompson 1887-Pos Board B36 LIGAND BINDING KINETICS OF A 2A R NANODISCS USING FLUORESCENCE ANISOTROPY. John M. Pettersen , Anne S. Robinson 1888-Pos Board B37 Travel Award Winner FLUORESCENT DRUG ANALOGUES TO STUDY DRUG-TARGET INTERAC TIONS IN INTACT CELLS. Soumyabrata Banik , Paolo Annibale 1889-Pos Board B38 ELECTROCHEMICAL VISUALIZATION OF SINGLE-MOLECULE THIOL SUB STITUTION WITH NANOPORE MEASUREMENT. Chao-Nan Yang , Ji-Chang Zhang, YIi-Lun Ying, Yi-Tao Long 1890-Pos Board B39 SMALL-MOLECULE ALLOSTERIC MODULATORS OF SERCA2A FOR PHAR MACEUTICAL THERAPY OF HEART FAILURE. Osha Roopnarine , Saman tha Yuen, Elisa Bovo, Marzena Baran, Andrew R. Thompson, Robyn T. Rebbeck, Aleksey V. Zima, Courtney C. Aldrich, David D. Thomas 1891-Pos Board B40 NANOPORE SENSING MULTIVALENT LIGAND-RECEPTOR INTERAC TIONS FOR REVEALING THE INFECTIVITY OF THE OMICRON VARIANT TO ACE2. Yongyong Wang , Hui Ma, Linyue Ma, Yi-Lun Ying, Yi-Tao Long 1892-Pos Board B41 FRET BASED ASSAYS FOR THE EXAMINATION OF ACTIVITY CONDITIONS AND AUTOPROTEOLYSIS RATES OF INFLAMMATORY CASPASES. Sophie Young, Kaitlyn Shelley, Caitlin E. Karver, Cathrine A. Southern

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