BPS2024 Full Program & Abstracts

Enzyme Function, Cofactors, and Post-Translational Modifications (Boards B92 - B108) 1943-Pos Board B92 DECIPHERING THE ORIGIN OF PROTEASE ACTIVITY BY SINGLE MOLE CULE STUDIES. Emily W. Sørensen , Freya Reinhold, Andreas Faber, Errika Voutyritsa, Sune M. Christensen, Nikos S. Hatzakis 1944-Pos Board B93 SIGNATURES OF 5-METHYLCYTOSINE MODIFICATION IN DNA BY THE TUMOR SUPPRESSOR TET2. Noa Erlitzki , Rahul M. Kohli 1945-Pos Board B94 Travel Award Winner MOLECULAR INSIGHT INTO THE MAMMALIAN SLFN14 RIBONUCLE ASE. Justin M. Van Riper , Arleth O. Martinez-Claros, Lie Wang, Sweta Maheshwari, Monica Pillon 1946-Pos Board B95 UNDERSTANDING THE ENSEMBLE EFFECT IN PHOTOENZYME PHOTO PHYSICS AND REACTIVITY VIA FIRST PRINCIPLES SIMULATIONS AND MACHINE LEARNING. Sijia Dong , Bhumika Jayee, Gustavo Mondragon, Felipe Curtolo, Nithin Chintala, Zheyu Zhang 1947-Pos Board B96 E2-TYPE UBIQUITIN-CONJUGATING ENZYMES PROBED WITH NANO BODY TOOLS. Pavana Suresh , Nanette Becht, Zhen-Yu Jim Sun, Novalia Pishesha, Hidde Ploegh 1948-Pos Board B97 ENHANCING THE CATALYTIC ACTIVITY OF ENZYMES THROUGH TUNNEL AMINO ACID MODIFICATIONS. THE CASE OF NITRILE HYDRATASE, A BIO CATALYST WITH POSTTRANSLATIONAL MODIFICATIONS USED IN AMIDE PRODUCTION. Lukasz Peplowski 1949-Pos Board B98 PTM-PSI: A PYTHON PACKAGE TO FACILITATE THE COMPUTATIONAL INVESTIGATION OF POST-TRANSLATIONAL MODIFICATION ON PRO TEIN STRUCTURES AND THEIR I MPACTS ON DYNAMICS AND FUNC TIONS. Margaret S. Cheung , Daniel Mejia-Rodriguez, Hoshin Kim, Natalie Sadler, Xiaolu Li, Pavlo Bohutskyi, Marat Valiev, Weijun Qian 1950-Pos Board B99 PROMOTING PROTEIN TYROSINE PHOSPHATASE J ACTIVITY WITH A TRANSMEMBRANE PEPTIDE AGONIST INHIBITS CANCER-ASSOCIATED PHENOTYPES. Sophie Rizzo , Soohyung Park, Victor Vasquez Montes, Will Hart, Wonpil Im, Alexey Ladokhin, Matthew J. Lazzara, Damien Thévenin 1951-Pos Board B100 IMPACT OF EXTERNAL FACTORS ON ENZYMATIC CATALYSIS: THE CASE OF DISTAL MUTATIONS AND SOLVENT ENVIRONMENT. Madison Berger, Shubham Chatterjee, Jorge Nochebuena, Gerardo A. Cisneros 1952-Pos Board B101 FULL-LENGTH KNOWS BETTER: SUBSTRATE SELECTIVITY OF THE PROTEASE DOMAIN OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA). Constanza Torres-Paris , Harriet J. Song, Elizabeth A. Komives 1953-Pos Board B102 MALONDIALDEHYDE MODIFICATION DECREASES MEMBRANE BINDING BY SECRETORY C2 DOMAINS. David Soto 1954-Pos Board B103 Travel Award Winner CLARIFYING THE CATALYTIC MECHANISM OF THE DNASE1 FAMILY. Jon J. McCord , Johanna Villarreal, Ruibin Liang, Roger B. Sutton 1955-Pos Board B104 FUNCTIONAL CHARACTERIZATION OF PROTEIN STRUCTURE 2O14. Gregg Holliday , Julia R. Koeppe

1931-Pos Board B80 ACCESSING THE HIDDEN CONFORMATIONAL INTERMEDIATES IN THE NUCLEOTIDE SWITCH TRANSITION OF ARF1 PROBED USING MD SIMULATIONS AND PRESSURE PERTURBATION SAXS BASED ENSEMBLE OPTIMIZATION. Tejaswi Naidu Koduru , Noam Hantman, Edgar Peters, Catherine A. Royer 1932-Pos Board B81 MOLECULAR MECHANISMS OF PH-DEPENDENT ALLOSTERY IN SH2 CONTAINING SIGNALING PROTEINS. Papa Kobina Van Dyck, Elijah Gorski, Logan Hoffmann, Katharine A. White 1933-Pos Board B82 NEGATIVE INTER-DOMAIN COUPLING IN E. COLI ADENYLATE KI NASE. Anna Andrick , Miranda Russo, Sarah J. Brantley, Ananya K. Majumdar, Vincent J. Hilser 1934-Pos Board B83 DECIPHERING S100B ALLOSTERIC SIGNALING: THE ROLE OF TRTK AS AN ENSEMBLE MODULATOR. Riya Samanta, Xinhao Zhuang, Kristen Varney, David J. Weber, Silvina Matysiak 1935-Pos Board B84 CEST NMR CHARACTERIZATION OF FUNCTIONAL DOMAIN UNFOLDING IN ADENYLATE KINASE. Sarah J. Brantley , Miranda Russo, Ananya K. Majumdar, Vincent J. Hilser 1936-Pos Board B85 PROTEIN-PROTEIN INTERACTIONS IN THE PHENYLPROPANOID AND FLAVONOID PATHWAYS OF SORGHUM BICOLOR . Eric P. Jacobo , Jacob A. Lewis, ChulHee Kang, James A. Brozik 1937-Pos Board B86 PRODUCT-STABILIZED FILAMENTATION BY HUMAN GLUTAMINE SYNTHETASE ALLOSTERICALLY TUNES ACTIVITY. Eric R. Greene , Richard Muniz, Hiroki Yamamura, Samuel Hoff, Angelika Arada, Priyanka Bajaj, Daphne Chen, John D. Lee, Massimiliano Bonomi, Justin M. Kollman, James Fraser 10 1938-Pos Board B87 Travel Award Winner STRUCTURES AND STABILITY OF SARS-COV-2 SPIKE S2 SUBUNIT MU TANTS TARGETING INTER-SUBUNIT INTERACTIONS. Ruth J. Parsons , Alexandria Calloway, Ellie Zhang, Bhishem Thakur, Katarzyna Janowska, Priyamvada Acharya 1939-Pos Board B88 PROBING HYDRATION DYNAMICS OF ANTIFREEZE PROTEIN M1.1 BY NMR SPECTROSCOPY. Jacob T. Zangaro , Crystal I. Stackhouse, Nathaniel V. Nucci 1940-Pos Board B89 NMR RELAXTION STUDY OF WILD-TYPE AND ALA97SER TRANTHYRE TIN. Yu-Chen Feng 1941-Pos Board B90 FAST DYNAMICS SHAPE THE FUNCTION OF THE AAA+ MACHINE CLPB: LESSONS FROM SINGLE-MOLECULE FRET SPECTROSCOPY. Inbal Riven , Hisham Mazal, Marija Iljina, Gilad Haran 1942-Pos Board B91 NEGATIVE ALLOSTERIC MODULATION OF THE MU-OPIOID RECEP TOR. Evan S. O’Brien , Vipin A. Rangari, Amal El Daibani, Shainnel O. Eans, Betsy White, Haoqing Wang, Yuki Shiimura, Kaavya Krishna Kumar, Kevin Appourchaux, Chensong Zhang, Jesper M. Mathiesen, Tao Che, Jay P. McLaughlin, Susruta Majumdar, Brian K. Kobilka

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