BPS2024 Full Program & Abstracts

Membrane Pumps, Transporters, and Exchangers II (Boards B368 - B393) 2219-Pos Board B368 THE STRUCTURAL BASIS OF PROSTAGLANDIN EFFLUX BY MRP4. Robert M. Stroud , Sergei Pourmal, Evan Green, Ruchika Bajaj, Ilan E. Chemma ma, Giselle Knudsen, Meghna Gupta, Andrej Sali, Yifan Cheng, Charles S. Craik, Deanna Kroetz 2220 -Pos Board B369 STRUCTURAL BASIS OF AGONIST SPECIFICITY OF Α1A-ADRENERGIC RECEPTOR. Jinan Wang , Minfei Su, Guoqing Xiang, Hung N. Do, Josh T. Levitz, Yinglong Miao, Xin-yun Huang 2221-Pos Board B370 STRUCTURAL DETERMINANTS OF SERCA CALCIUM PUMP REGULA TION BY MICROPEPTIDES ALN AND ELN. Rhys A. Smith , Songlin Wang, Venkateswara Reddy Uddigiri, Michael P. Dalton, Gianluigi Veglia, Seth L. Robia 2222 -Pos Board B371 MOLECULAR RATIONALE FOR THE SPECIFICITIES OF MEX TRANSPORT ERS OF PSEUDOMONAS AERUGINOSA. Mohd Athar, Giuliano Malloci, Paolo Ruggerone, Attilio V. Vargiu 2223 -Pos Board B372 INSIGHTS INTO THE GATING AND TRANSPORT MECHANISMS OF THE LYSOSOMAL CHLORIDE/PROTON ANTIPORTER CLC-7. Jacob K. Hilton , Abby Lin, Eric Sefah, Michael Grabe, Joanne Parker, Justin Deme, Susan Lea, Simon Newstead, Joseph A. Mindell 2224 -Pos Board B373 LIVE-CELL FRET BIOSENSORS FOR HIGH-THROUGHPUT SCREENING TAR GETING THE SERCA2A-DWORF COMPLEX. Rebecca L. Schultz , Samantha L. Yuen, Robyn T. Rebbeck, Bengt Svensson, Osha Roopnarine, David D. Thomas 2225-Pos Board B374 SUBSTRATE BINDING AND CONFORMATIONAL TRANSITIONS OF SODI UM-GLUCOSE TRANSPORTERS. Fiona B. Naughton , John M. Rosenberg, Michael Grabe 2226-Pos Board B375 QUANTIFYING THE DEGREE OF PLASMA MEMBRANE LOCALIZATION IN NA + /K + -ATPASE AND SCREENING FOR FXYD1 MUTANTS. Patryk Karkut 2227-Pos Board B376 COMPUTATIONAL ANALYSES OF SERCA, PHOSPHOLAMBAN, AND SARCOLIPIN COMPLEXES. Bengt Svensson , Joseph M. Autry, Razvan L. Cornea, Robyn T. Rebbeck, David D. Thomas 2228 -Pos Board B377 Travel Award Winner A NEW ATP1A1 VARIANT ASSOCIATED WITH A NOVEL DISEASE PHENO TYPE. Lauren P. Conger , Yuval Weigl, Kerri Spontarelli, Kazuhiro Abe, Orit Reish, Pablo Artigas 2229 -Pos Board B378 NANODISC DIAMETER AFFECTS THE ATP HYDROLYSIS RATE OF ABC TRANSPORTER. Annabella Nouel Barreto , Maria E. Zoghbi 2230 -Pos Board B379 ATOMIC-RESOLVED DESCRIPTION OF ANION BINDING AND THE ALTER NATING ACCESS MECHANISM OF ANION EXCHANGER 1 (BAND 3). Tianle Chen , Francesca Vallese, Karan Kapoor, Oliver B. Clarke, Emad Tajkhor shid 2231-Pos Board B380 Travel Award Winner FUNCTIONAL EVALUATION OF A CMT2DD-CAUSING ATP1A1 VARI ANT. Kerri Spontarelli , Steven S. Scherer, Shawn J. Bird, Brett McCray, Pablo Artigas

2232 -Pos Board B381 MOLECULAR DYNAMICS SIMULATIONS FOR ATOMIC-LEVEL CHARAC TERIZATION OF LIPID INTERACTIONS WITH THE BOVINE MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 1 (BMRP1). Samuel W. Mwatha , Mahmoud Moradi 2233 -Pos Board B382 ELECTRON TRANSFER DIRECTIONALITY IN TYPE II PHOTOSYNTHETIC REACTION CENTERS. Rongmei Wei 2234 -Pos Board B383 MODULATION MECHANISM OF A GLUTAMATE TRANSPORTER HOMO LOG BY FATTY ACIDS. Xiaoyu Wang , Gabriel Glenn A. Gregorio, Radda Rusinova, Olga Boudker 2235-Pos Board B384 A SIMPLE FIDUCIAL-ASSISTED APPROACH TO SOLVE SMALL MEMBRANE TRANSPORTER STRUCTURES USING CRYO-EM. Pujun Xie , Yan Li, Huihui Kuang, Da-Neng Wang, Nathaniel J. Traaseth 2236-Pos Board B385 Travel Award Winner MECHANISM OF ANION EXCHANGE, SMALL-MOLECULE INHIBITION, AND LIPID REGULATION OF PENDRIN. Lie Wang , Anthony Hoang, Eva Gil-Iturbe, Arthur Laganowsky, Matthias Quick, Ming Zhou 2237-Pos Board B386 Travel Award Winner NEW INSIGHTS INTO THE MOLECULAR MECHANISMS OF THE COU PLING OF PROTON AND CHLORIDE IN CLC ANTIPORTERS. Amy R. Nava , Juergen Kreiter, Chih-Ta Chien, Deniz Aydin, Catalina Salcedo, Natasa Trifkovic, Wah Chiu , Wah Chiu , Ron O. Dror, Merritt Maduke 10 2238-Pos Board B387 PROTON-DRIVEN ALTERNATING ACCESS AND BROAD-SPECIFICITY IN SPNS LIPID TRANSPORTERS. Samantha Gies, Kevin Jagessar, Ali Rasouli, Sepehr Dehghani-Ghahnaviyeh, Ian Miller, Emad Tajkhorshid, Reza Dastvan 2239 -Pos Board B388 INVESTIGATION OF GABA TRANSPORT AND THE GABA/NA + RELATION SHIP IN HUMAN GAT1 USING SOLID SUPPORTED MEMBRANE-BASED ELECTROPHYSIOLOGY. Rocco Zerlotti , Maria Barthmes, Andre Bazzone 2240 -Pos Board B389 OPPOSITE EFFECTS OF EXTRACELLULAR CHLORIDE AND PH ON CLOSELY RELATED CLC-6 AND CLC-7 TRANSPORTERS SUGGEST NON-OVERLAP PING FUNCTION IN ENDO-LYSOSOMES. Maria Antonietta Coppola , Paola Gavazzo, Ilaria Zanardi, Abraham Tettey-Matey, Antonella Lianto nio, Paola Imbrici, Peying Fong, Michael Pusch 2241-Pos Board B390 THE MECHANISM OF MAMMALIAN PEPTIDE TRANSPORTERS. Simon M. Lichtinger , Simon Newstead, Philip C. Biggin 2242 -Pos Board B391 AN ION-INDEPENDENT INTERMEDIATE UNDERLIES THE EVOLUTION ARY SWITCH BETWEEN SODIUM AND PROTON-COUPLED GLUTAMATE TRANSPORTER HOMOLOGUES. Krishna Reddy , Burha Rasool, Olga Boudker 2243 -Pos Board B392 EFFECT OF ATP AND NON-HYDROLYSABLE ANALOGS ON THE NUCLEO TIDE BINDING DOMAIN DIMERIZATION OF A HUMAN ABC TRANSPORT ER. Maria E. Zoghbi 2244 -Pos Board B393 MULTISCALE KINETIC MODELING REVEALS FUNDAMENTAL DIFFER ENCES BETWEEN ELECTRICALLY- AND CHEMICALLY-DRIVEN ION TRANS PORT. Jessica M.J. Swanson

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