BPS2024 Full Program & Abstracts

2193-Pos Board B342 IDR CARTOGRAPHY: MAPPING REGULATORY ELEMENTS ALONG THE INTRINSICALLY DISORDERED REGIONS OF TRP ION CHANNELS. Ute A. Board B343 A HUMAN GENOME VARIANT HOTSPOT IN THE TRPV1 ANKYRIN REPEAT DOMAIN OPENS THE DOOR TO STRUCTURE-FUNCTION INSIGHT FOR A CONSERVED METHIONINE. Grace Wulffraat, Andres Jara Oseguera, Eric N. Senning Ligand-Gated Channels I (Boards B344 - B367) 2195-Pos Board B344 STRUCTURAL CHARACTERIZATION OF REGULATION BY A DYNAMIC N TERMINAL MODULE IN THE PENTAMERIC LIGAND-GATED ION CHANNEL DECLIC. Olivia Andén , Urska Rovsnik, Marie Lycksell, Rebecca J. Howard, Erik R. Lindahl 2196-Pos Board B345 MOLECULAR DYNAMICS SIMULATIONS OF NEURONAL NICOTINIC ACE TYLCHOLINE RECEPTOR ALLOSTERIC MODULATION. Samantha Chu, Ela Chintagunta, Yuxuan Zhuang, Rebecca J. Howard, Erik R. Lindahl, Mark M. Levandoski 2197-Pos Board B346 MECHANISTIC INSIGHTS OF PHOSPHOLIPID MODULATION IN A PENTA MERIC LIGAND-GATED ION CHANNEL. Brandon Tan , Hanrui Xu, Wayland Board B347 DISCOVERING CRYPTIC POCKET OPENING AND LIGAND BINDING IN A VESTIBULAR SITE OF THE 5-HT 3A RECEPTOR. Nandan Haloi , Emelia Karls son, Rebecca J. Howard, Erik R. Lindahl 2199-Pos Board B348 STRUCTURE-ACTIVITY RELATIONSHIPS CONFIRM ALTERNATIVE PEPTIDE BINDING MODES IN MOLLUSK AND ANNELID FMRF-AMIDE GATED SODIUM CHANNELS (FANACS). Emily J.S. Claereboudt , Mowgli Dan damudi, Timothy Lynagh 2200 -Pos Board B349 CONSTANT-PH MOLECULAR DYNAMICS SIMULATIONS OF PROGRESSIVE ACTIVATION IN A PROTON-GATED ION CHANNEL. Anton Jansen , Paul Bauer, Rebecca J. Howard, Berk Hess, Erik Lindahl 2201-Pos Board B350 DYNAMIC STUDY OF THE TRANSMEMBRANE DOMAIN (TMD) OF GLYCINE RECEPTOR (GLYR) BY VOLTAGE CLAMP FLUOROMETRY. Maria Vangelatou , Karima Medjebeur, Laurie Peverini, Pierre-Jean Corringer 2202 -Pos Board B351 PENTAMERIC CHANNEL-RECEPTORS A7/A3B4 AND LIPIDS: INTERAC TIONS STUDIES. Nour Awad , Nathalie Barilone, Marie Prevost, Pierre Jean Corringer 2203 -Pos Board B352 SYMMETRY-ADAPTED MARKOV STATE MODELS OF CLOSING, OPENING, AND DESENSITIZING IN ΑLPHA-7 NICOTINIC ACETYLCHOLINE RECEP TORS. Yuxuan Zhuang , Rebecca J. Howard, Erik R. Lindahl 2204 -Pos Board B353 DETERMINANTS FOR Α7NACHR-JAK2 COUPLING TO ENABLE CHO LINERGIC ANTI-INFLAMMATORY SIGNALING. Tommy S. Tillman, Vasyl Bondarenko, Qiang Chen, Yan Xu, Pei Tang 2205-Pos Board B354 Travel Award Winner BINDING AND GATING OF NEURONAL ACETYLCHOLINE RECEPTORS ASSOCIATED WITH NICOTINE WITHDRAWAL. Nadira Khatoon , Tapan K. Nayak Hellmich 2194-Pos W. Cheng 2198-Pos

2206-Pos Travel Award Winner MECHANISM OF ALLOSTERIC COMMUNICATION IN THE NEUROMUSCU LAR ACETYLCHOLINE RECEPTORS. Tapan K. Nayak , Rachita Sharma 2207-Pos Board B356 STRUCTURAL BASIS FOR PARTIAL AGONISM AND ALLOSTERIC MODULA TION OF THE 5HT3AR. Kevin C. Felt , Madeleine Stauffer, Leslie Salas Estrada, Marta Filizola, Sudha Chakrapani 2208 -Pos Board B357 PHYSIOLOGICAL AND PHARMACOLOGICAL MODULATION OF ALPHA3 GLYCINE RECEPTORS. Kayla J. Kindig , Eric Gibbs, Seiferth David, Philip C. Biggin, Sudha Chakrapani 2209 -Pos Board B358 FROM HEAD TO TAIL - ATOMISTIC MECHANISM OF LONG-RANGE COUPLING FROM THE CYTOSOLIC SENSOR DOMAIN TO THE SELECTIVITY FILTER IN TREK K 2P CHANNELS. Marcus Schewe , Berke Türkaydin, Elena B. Riel, Friederike Schulz, Johann Biedermann, Thomas Baukrowitz, Han Sun 2210-Pos Board B359 STRUCTURE AND DYNAMICS OF DIFFERENTIAL LIGAND BINDING IN THE HUMAN RHO-TYPE GABA A RECEPTOR. John Cowgill, Chen Fan, nandan haloi, Yuxuan Zhuang, Rebecca J. Howard , Erik Lindahl 2211-Pos Board B360 KCSA ION BINDING AFFINITY LESSENING CAUSED BY A NOVEL MECHA NOSENSITIVE GATING MECHANISM AND CRYSTALIZATION CONDI TIONS. Megan M. Skains , D. Marien Cortes, Luis G. Cuello 2212-Pos Board B361 Travel Award Winner COMPUTATIONAL CHARACTERIZATION OF THE BINDING OF ALLOSTERIC POTENTIATORS TO THE Α4-Α4 INTERFACE OF THE Α4Β2 LS NICOTINIC ACETYLCHOLINE RECEPTOR. Franco Viscarra , Philip C. Biggin, Isabel Board B362 INHIBITION OF AMPA-SUBTYPE IONOTROPIC GLUTAMATE RECEP TORS. William D. Hale , Alejandra Montaño Romero, Lucas Dillard, Albert Y. Lau, Richard Huganir, Edward C. Twomey 2214-Pos Board B363 STRUCTURAL BASIS OF CLOSED GROOVE SCRAMBLING BY A TMEM16 PROTEIN. Zhang Feng , Omar E. Alvarenga-Cruz, Alessio Accardi 2215-Pos Board B364 LIGAND-GATED ION CHANNEL MODULATION BY STIMULANT DERIVA TIVES VIA A VESTIBULAR CAVITY. Emelia Karlsson , Olivia Andén, Chen Fan, Zaineb Fourati, Ahmed Haouz, Yuxuan Zhuang, Marc H. Delarue, Rebecca J. Howard, Erik R. Lindahl 2216-Pos Board B365 CONFIRMATORY AND ILLUMINATING INVESTIGATION OF CRUSTACEAN NMDA RECEPTORS. Oksana Sintsova , Yuhong Wang, Timothy Lynagh 2217-Pos Board B366 Travel Award Winner STRUCTURAL DETERMINANTS, PATHWAYS, AND ENERGETICS OF GABA BINDING AND UNBINDING TO THE GABA A RECEPTOR. Ayobami Diyaolu , Peter Obi, Ramya Chandar Charles Maria soosai, Senthil Natesan 2218-Pos Board B367 ROLE OF M2-M3 LINKER BACKBONE-TO-BACKBONE HYDROGEN BONDS IN Α1Β2Γ2L GABA A RECEPTOR GATING. Cecilia M. Borghese , Anvita Bhatt, Jason D. Galpin, Christopher A. Ahern, Marcel P. Goldschen-Ohm Board B355 Bermudez 2213-Pos

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