BPS2024 Full Program & Abstracts

2165-Pos Board B314 STRUCTURAL AND FUNCTIONAL STUDIES OF TRPML1 IN SITU . Bridget M. McVeigh , Gary A. Bradshaw, Robyn J. Eisert, Shrawan Mageswaran, Ricardo Righetto, Lorenz Lamm, Benjamin Engel, Yi-Wei Chang, Marian Kalocsay, Vera Moiseenkova-Bell 2166-Pos Board B315 SELECTIVITY OF IONIC PATHWAYS THROUGH TRPM3 CHANNEL VARI ANTS AND MUTANTS. Júlia Castro-Marsal, Mara Hansen, Homa Ghatreh Samani, Jurek Loho, Sandeep Dembla, Doris Newel, Raissa Enzeroth, Johannes Oberwinkler 2167-Pos Board B316 COMPLEX WAVEFORM OF THE CALCIUM-ACTIVATED TRPM4 ION CHAN NEL CURRENT. Yuhua Tian , Abdullah Al Tekreeti, Jie Zheng 2168-Pos Board B317 TRPM4 MODULATES FOCAL ADHESION-ASSOCIATED CALCIUM SIGNALS AND DYNAMICS. Ian Silva , Mariana Brunett, Mónica Cáceres, Oscar Cerda 2169-Pos Board B318 STRUCTURAL DYNAMICS AT CYTOSOLIC INTER-PROTOMER INTERFACES CONTROL GATING OF A MAMMALIAN TRPM5 CHANNEL. Sebastian J. Board B319 TRPM5 ACTIVATION DEPENDS ON A SYNERGISTIC EFFECT OF CALCIUM AND PKC PHOSPHORYLATION. Alaa Nmarneh 2171-Pos Board B320 USING TEA AND TRIS UPTAKE FOR BLOCKADE OF TRPM7 CHANNELS IN INTACT CELLS. Katherine G. Holderby, J. Ashot Kozak 2172-Pos Board B321 TRPM7 MG 2+ -PERMEABLE CHANNELS ARE PRIME TARGETS AGAINST HIGHLY-AGGRESSIVE B-CELL LEUKEMIAS. Victor De la Rosa, Caroline R. Delma, Aiola Stoja, Crystal R. Archer, Andrea Fleig, David Horgen, Edward Medina, Mark S. Shapiro 2173-Pos Board B322 TRPM7 KINASE IS KEY TO HYPOMAGNESEMIA-INDUCED MITOCHON DRIAL DYSFUNCTION AND CARDIAC DIASTOLIC DYSFUNCTION. Man Liu , Hong Liu, Gyeoung-Jin Kang, Feng Feng, Samuel C. Dudley 2174-Pos Board B323 TRPM8 MUTATIONS ASSOCIATED WITH PERSISTENT OCULAR PAIN AFTER REFRACTIVE SURGERY: D665N & V915M. Mohammad-Reza Ghovanloo , Philip R. Effraim, Sidharth Tyagi, Xiaoyang Cheng, Jun-Hui Yuan, Betsy R. Schulman, Deborah S. Jacobs, Sulayman D. Dib-Hajj, Stephen G. Waxman 2175-Pos Board B324 Travel Award Winner QUANTITATIVE DETERMINATION OF VANILLOID ACTIVATION IN TRPV1. Shisheng Li , Phuong T. Nguyen, Simon Vu, Vladimir Yarov-Yaro voy, Jie Zheng 2176-Pos Board B325 A CORNEAL NEURALGIA TRPV1 MUTATION INCREASES RESPONSE TO ACIDIC PH AND ALTERS AGONIST SENSITIZATION AND DESENSITIZA TION. Roberta Gualdani , Philippe Gailly, Solène Barbeau, Deborah S. Jacobs, Sulayman Dib-Hajj, Stephen G. Waxman 2177-Pos Board B326 STRUCTURAL INSIGHTS INTO LIGAND MODULATION OF TRPV2. Ruth Pumroy , Julia Rocereta, Toni Sturhahn, Andreas Leffler, Vera Moiseen kova-Bell Karuppan 2170-Pos

2178-Pos Board B327 EXPLORING THE ROLE OF TRPV2 IN NEURONAL DEVELOPMENT. Elaine M. Mihelc , Dirk H. Siepe, Anushka Chakraborty, Marian Kalocsay, Vera Moiseenkova-Bell 2179-Pos Board B328 STRUCTURE OF HUMAN TRPV2 ION CHANNEL INFORMS DIFFERENCES IN ACTIVATION PROPERTIES. Julia Rocereta , Ruth A. Pumroy, Tabea Fricke, Christine Herzog, Andreas Leffler, Vera Y. Moiseenkova-Bell 2180-Pos Board B329 INHIBITION OF TRPV3 CHANNELS ATTENUATES UVB-INDUCED SKIN INFLAMMATION. Yaxuan Qu , KeWei Wang 2181-Pos Board B330 THE ROLE OF TRANSIENT RECEPTOR POTENTIAL VANILLOID 4 IN CAR DIAC AUTOPHAGY. Matthew R. Hayden , Michelle D. Lambert, Tim L. Domeier 2182-Pos Board B331 CHARACTERIZATION OF ION PERMEATION MECHANISM IN TRPV6 CAL CIUM CHANNELS. Muhammed Aktolun , Maria G. Kurnikova 2183-Pos Board B332 Travel Award Winner DECIPHERING THE MECHANISM OF CHOLESTEROL SENSING IN TRPC3 THROUGH PHOTOPHARMACOLOGY. Hazel Erkan-Candag , Daniel de Jesús Platero Rochart, Oleksandra Tiapko, Pedro Alejandro Sánchez Murcia, Toma Glasnov, Thomas Stockner, Klaus Groschner 2184-Pos Board B333 Travel Award Winner THE PAIN RECEPTOR TRPA1 DISPLAYS DIFFERENTIAL BINDING MECHA NISMS TO THC AND CBD. Tala Amawi 2185-Pos Board B334 PLACENTAL MAMMALS ACQUIRED TRPA1 HYPOXIA SENSITIVITY TO PRO TECT THE FETUS FROM THE INSULTS DUE TO MATERNAL ANEMIA. Ji acheng H. Sun , Yasuo Mori, Nobuaki Takahashi 2186-Pos Board B335 UNRAVELING THE BINDING SITE OF AMG-9090 ON THE PAIN RECEPTOR TRPA1. Mariana Ghantous 2187-Pos Board B336 Travel Award Winner A SYNTHETIC METHOD TO ASSAY POLYCYSTIN ION CHANNEL BIOPHYS ICS. Megan Larmore , Orhi Esarte Palomero, Neha P. Kamat, Paul G. DeCaen 2188-Pos Board B337 DISENTANGLING HUMAN TRPV1 POLYMODAL ACTIVATION AND MECHANISMS. Helen F. Mann , Dustin Luu, Anna-Marie Agyepong, Wade D. Van Horn 2189-Pos Board B338 BRIDGING THE GAP ON TRPV2 PHARMACOLOGY. Alex Peralvarez Marin , Eric Catalina-Hernandez, Mohsen Habibnia, Mario López-Martín 2190-Pos Board B339 A PAINFUL PARADOX: HOW A DRASTIC TRPA1 TRUNCATION CONFERS GAIN-OF-FUNCTION. Avnika Bali, Samantha Schaefer, Isabelle Trier, Alice L. Zhang, Lilian Kabeche, Candice E. Paulsen 2191-Pos Board B340 STRUCTURAL BASIS OF REGULATION OF ENDOLYSOSOMAL CHANNEL TRPML2. Sunjae Park , Zhengshan Hu, Jian Yang 2192-Pos Board B341 COUPLING ENZYMATIC ACTIVITY AND GATING IN AN ANCIENT TRPM CHANZYME AND ITS MOLECULAR EVOLUTION. Sushant Kumar , Yihe Huang, Wei Lu, Juan Du

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