BPS2024 Full Program & Abstracts

Anion Channels (Boards B394 - B397)

2257-Pos Board B406 PATHOGENIC CARDIAC THICK FILAMENT VARIANTS: A STRUCTURAL PERSPECTIVE. Debabrata Dutta , Yuri Kim, Jonathan G. Seidman, Roger Craig, Christine E. Seidman, Raul Padron 2258-Pos Board B407 2-DEOXY-ATP REDUCES THE CARDIAC DEPRESSIVE EFFECT OF ACIDO SIS. Meredith A. Redd , Tim S. McMillen, Mike K. Woodward, Saf fie Mohran, Kristina B. Kooiker, Galina V. Flint, Laavan Suresh, Farid Moussavi-Harami, Jennifer Davis, Edward P. Debold, Michael Regnier 2259-Pos Board B408 AN ESTROGEN RECEPTOR AGONIST AND ANDROGEN RECEPTOR ANTAG ONIST INDEPENDENTLY ALTER CARDIAC CONTRACTILE MECHANICS IN MALE MICE. Brent Momb , Gillian Szabo, Joshua Mogus, Stuart Chipkin, Laura Vandenberg, Mark S. Miller 2260-Pos Board B409 STUDIES OF CA 2+ -ACTIVATED CONTRACTILITY USING SKINNED CRYOSEC TIONS OF HUMAN VENTRICULAR PAPILLARY MUSCLE SAMPLES FROM FROZEN STORAGE OF DISCARDED CLINICAL SPECIMENS COLLECTED IN BIOREPOSITORY. Han-Zhong Feng , Milburn Gregory Milburn, Kenneth S. Campbell, Jian-Ping Jin 2261-Pos Board B410 EFFECTS OF RADIATION ON HUMAN IPSC DERIVED CARDIOMYOCYTE MYOSIN FUNCTION EVALUATED BY SHG MICROSCOPY. Hideaki Fujita , Tomonobu Watanabe 2262-Pos Board B411 Travel Award Winner IMPACT OF CHRONIC ALCOHOL CONSUMPTION ON CARDIAC MYOSIN FUNCTION: ROLE OF OXIDATIVE STRESS. Adrien P. Chen , David V. Rasicci, Jinghua Ge, Neil Wood, Skylar M.L. Bodt, Omid Golestanian, Md Shah rier Amin, Anne Pruznak, Michael J. Previs, Charles H. Lang, Christopher Board B412 DIFFERENT MECHANISTIC AND MOLECULAR CUES MODULATE DIVER GENT PHENOTYPES IN HCM AND DCM MUTATIONS TO TPM1. Saiti S. Halder , Michael J. Rynkiewicz, Jeffrey R. Moore, William Lehman, Stuart G. Campbell 2264-Pos Board B413 MYOSIN SOLUBILITY AND FOLDING ENHANCE ITS MOBILITY WITHIN CARDIAC MUSCLE SARCOMERES. Colleen M. Kelly, Jody L. Martin, Molly Coseno, Michael J. Previs 2265-Pos Board B414 Travel Award Winner MYBPC3 -C.772G>A MUTATION RESULTS IN HAPLOINSUFFICIENCY AND ALTERED MYOSIN CYCLING KINETICS IN A PATIENT INDUCED STEM CELL DERIVED CARDIOMYOCYTE MODEL OF HYPERTROPHIC CARDIOMY OPATHY. Sonette Steczina , Saffie Mohran, Logan Bailey, Tim McMillen, Kristina B. Kooiker, Neil B. Wood, Jennifer M. Davis, Michael J. Previs, Iacopo Olivotto, J. Manuel Pioner, Michael A. Geeves, Corrado Poggesi, Michael Regnier 2266-Pos Board B415 PROBING THE SRX STATE IN CARDIAC MYOFILAMENTS BY SECOND HARMONIC-GENERATION MICROSCOPY. Leonardo Sacconi , Beatrice Scellini, Nicoletta Piroddi, Corrado Poggesi, Cecilia Ferrantini, Riccardo Cicchi, Chiara Tesi 2267-Pos Board B416 DEFINING THE STRUCTURE AND ORIENTATION OF THE N-TERMINAL DOMAIN OF CARDIAC TROPONIN T IN RELATIONSHIP TO ACTIN. Grace Heffernon , Romi Castillo, Jil C. Tardiff M. Yengo 2263-Pos

2245-Pos Board B394 CHLORIDE INTRACELLULAR CHANNEL (CLIC) 6 FORMS A REDOX SENSITIVE ANION CHANNEL. Veronica Loyo-Celis, Shridhar K. Sanghvi, Devadendra Patel, Kamalpreet Kaur, Devasena Ppnnalagu, Yang Zheng, Sahej Bindra, Harmeet R. Bhachu, Isabelle Deschenes, Shubha Gururaja Rao, Harpreet Singh 2246-Pos Board B395 STRUCTURE AND DYNAMICS OF CHLORIDE ION CONDUCTION IN CFTR. Zhi Wei Zeng , Régis Pomès 2247-Pos Board B396 REGULATION OF CFTR BY THE MEMBRANE PHOSPHOLIPID PIP 2 . Ioanna Maria Vynichaki , Laszlo Csanady, Diomedes E. Logothetis 2248 -Pos Board B397 Travel Award Winner POLYUNSATURATED FATTY ACIDS REGULATE THE CALCIUM-ACTIVATED CHLORIDE CHANNEL TMEM16A ACTIVITY. Crystal Lara Santos Smooth Muscle and Cardiac Muscle Mechanics and Structure II (Boards B398 - B420) 2249 -Pos Board B398 COUPLED TR-FRET AND MOLECULAR DYNAMICS PREDICT NOVEL TROPOMYOSIN INTERACTIONS AND DISEASE MECHANISMS IN C-TERMI NAL TAIL OF CARDIAC TROPONIN T. Garrett Crosby , Garrett Hauck, Bai Hei, Melissa L. Lynn, Steven D. Schwartz, Jil C. Tardiff 2250-Pos Board B399 MOLECULAR DYNAMICS MODELS DEMONSTRATE ALTERATIONS IN TROPONIN’S FUNCTION CAUSED BY CARDIOMYOPATHY ASSOCIATED MUTATIONS. Sage Malingen , Matthew C. Childers, Travis Tune, Kerry Y. Kao, Thomas L. Daniel, Farid Moussavi-Harami, Michael Regnier 2251-Pos Board B400 THE SMALL MOLECULE TROPONIN ACTIVATOR CK-136 INCREASES MYO CYTE CONTRACTILITY IN HUMAN HEART FAILURE. Vivek P. Jani , Weikang Ma, James J. Hartman, Thomas C. Irving, David A. Kass 2252-Pos Board B401 FAVORABLE MYOSIN LOOP-4/TROPOMYOSIN INTERACTIONS ARE UNFAVORABLE FOR THE PRE- TO POST-POWERSTROKE STATE TRANSI TION. Michael J. Rynkiewicz , William Lehman 2253-Pos Board B402 CULTURING ENGINEERED HEART TISSUES UNDER FIBER AND FIBER SHEAR STRAINS WITH A NOVEL BIOREACTOR. Thomas S. Blum , Stuart G. Campbell 2254-Pos Board B403 METHYLGLYOXAL GLYCATION COMPETES WITH UBIQUITINATION, DISRUPTING SARCOMERE FUNCTION. Christine E. Delligatti , Michaela M. Door, Maria Papadaki, Thomas G. Martin, Christina Manakanatas, Roland Foisner, Attila Kiss, Jonathan A. Kirk 2255-Pos Board B404 OPEN-SOURCE ALGORITHM FOR HIGH-THROUGHPUT, NON-CONTACT ELASTICITY MEASUREMENTS OF IPSC-DERIVED CARDIOMYOCYTES. Adi than Kandasamy , Ricardo Serrano, Mark Mercola, Juan Carlos del Alamo 2256-Pos Board B405 A-BAND TRUNCATED TITIN TRANSMITS FORCE FROM THE Z-DISC TO THE M-LINE IN HUMAN DILATED CARDIOMYOPATHY MYOCARDIUM. Quen tin McAfee , Matthew A. Caporizzo, Keita Uchida, Kenneth C. Bedi, Ken neth B. Margulies, Zolt Arany, Benjamin L. Prosser

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