BPS2024 Full Program & Abstracts

Platform Voltage-Gated Na and Ca Ion Channels 8:15 am - 10:15 am, Room 113AB

Platform Protein Structure and Conformation I 8:15 am - 10:15 am, Room 201AB

F R I D A Y

S U N D A Y

Co-Chairs Hai Nguyen, University of California, Davis, USA Antonios Pantazis, Linköping University, Sweden 58-Plat 8:15 am

Co-Chairs Ugochi Isu, University of Arkansas Fayetteville, USA Mia Rosenfeld, NIH, USA 68-Plat 8:15 am

A DE NOVO DESIGNED PEPTIDE SELECTIVELY INHIBITS ARRHYTHMO GENIC LATE NA + CURRENT. Ryan W. Mahling , Bence Hegyi, Timothy M. Cho, Lucile Fossier, Steven O. Marx, Donald M. Bers, Manu Ben-Johny 59-Plat 8:30 am ELECTROPHYSIOLOGICAL CHARACTERIZATION OF NANOBODIES TAR GETING THE INACTIVATED STATE OF NAV1.7 VSD-IV. Hai M. Nguyen , Phuong T. Nguyen, Mark McCoy, Georgeon Sandrine, Shannon Gilhooly, Kayla M. Templeton, James S. Trimmer, Bruce D. Hammock, Jon T. Sack, Theanne N. Griffith, Bruno Correia, Heike Wulff, Vladimir Yarov-Yarovoy 60-Plat 8:45 am STRUCTURAL, BIOPHYSICAL, AND NEUROPHYSIOLOGICAL EFFECTS OF SCN2A MUTATIONS. Syed M.A. Wafa , Ghazaleh Yazdani, Timothy A. Fenton, Christopher H. Thompson, Roy Ben-Shalom, Alfred L. George 61-Plat 9:00 am INVESTIGATING THE CONNECTION BETWEEN DISORDER IN THE DI-DII LINKER AND NAV1.5 CHANNEL FUNCTION. Emily Wagner , Jacob Kelley, Martina Marras, Shashi Kumar, Kiersten Ruff, Jonathan R. Silva 62-Plat 9:15 am THE NEURONAL JUNCTOPHILINS INTERACT WITH THE II-III LOOP OF CA V 2.1. Stefano Perni, Kurt G. Beam 63-Plat 9:30 am REGULATION OF CAV2.1-CHANNELS BY THE MEMBRANE POTENTIAL. Kaiqian Wang , Michelle Nilsson, Fredrik Elinder, Antonios Pantazis 64-Plat 9:45 am DYSREGULATION OF CA V 1.1 DUE TO A CACNA2D4 MUTATION CAUSING EXERTIONAL HEAT STROKE. Juan A.M. de la Rosa , Allioune Fall, Natalie Roux-Buisson, Isabelle Marty, Julien Fauré, Amy Lee 65-FlashTalk 10:00 am MAPPING STRUCTURAL DISTRIBUTION AND GATING-PROPERTY IMPACTS OF DISEASE-ASSOCIATED MUTATIONS IN VOLTAGE-GATED SODIUM AND CALCIUM CHANNELS. Amin Akbari Ahangar , Eslam Elhanafy, Hyden Blanton, Jing Li 66-FlashTalk 10:05 am STRUCTURE OF AN EMC CHAPERONE:CA V COMPLEX REVEALS AN ION CHANNEL ASSEMBLY INTERMEDIATE AND A HOLDASE FUNCTION FOR THE EMC. Zhou Chen , Abhisek Mondal, Fayal Abderemane-Ali, Seil Jang, Sangeeta Niranjan, José L. Montaño, Balyn W. Zaro, Daniel L. Minor 67-FlashTalk 10:10 am PATHOGENIC GATING PORE CURRENT CONDUCTED BY AUTISM-RELATED MUTATIONS IN THE NAV1.2 BRAIN SODIUM CHANNEL. Ahmed Eltokhi , Brian N. Lundstrom, Jin Li, William A. Catterall, Tamer M. Gamal El-din

GLYCOPROTEOMIC LANDSCAPE AND STRUCTURAL DYNAMICS OF TIM FAMILY IMMUNE CHECKPOINTS ENABLED BY MUCINASE SME AND MO LECULAR DYNAMICS SIMULATIONS. Mia A. Rosenfeld , Fiona L. Kearns, Joann Chongsaritsinsuk, Alexandra Steigmeyer, Keira E. Mahoney, Taryn M. Lucas, Deniz Ince, Alexandria Battison, Marie A. Hollenhorst, D. Judy Shon, Carolyn R. Bertozzi, Michael J. Farracane, Mark A. Lemmon, Stacy A. Malaker, Rommie E. Amaro 69-Plat 8:30 am MOLECULAR SIMULATIONS OF THE INFLUENCE OF CROWDERS ON ENZYMES: FROM DOMAIN MOTION TO THE ACTIVE SITE. Eva Pluha rova , Stepan Timr, Zuzana Sochorova Vokacova, Human A. Nori, Kristin M. Slade 70-Plat 8:45 am SCIPION FLEXIBILITY HUB AND SCIPION CHEM: NEW FRAMEWORKS COUPLING COMPUTATIONAL BIOPHYSICS OF PROTEIN DYNAMICS AND VIRTUAL SCREENING TO CRYO-ELECTRON MICROSCOPY. James M. Krieger , David Herreros, Daniel del Hoyo, Yunior Fonseca, Marcos Grag era, Carlos P. Mata, Alba Lomas, Eugenia Ulzurrun, Nuria E. Campillo, Pablo Conesa, Carlos Oscar S. Sorzano, Jose Maria Carazo 71-Plat 9:00 am UNRAVELING THE CONFORMATIONAL DYNAMICS OF UMOD PROTEIN VARIANTS IN AUTOSOMAL DOMINANT TUBULOINTERSTITIAL KIDNEY DISEASE: INSIGHTS FROM MOLECULAR DYNAMICS SIMULATIONS. Seulki Kwon , Jordan Safer, John Lin, Felichi M. Arines, Hyery Yoo, Silvana Bazúa, Keith Keller, Jillian Shaw, Juan Lorenzo Pablo, Anna Greka, Su maiya Iqbal 72-Plat 9:15 am ELUCIDATING THE CONFORMATIONAL AND BINDING DYNAMICS OF STAPLED PEPTIDES: INSIGHT FROM ENHANCED SAMPLING. Asha R. Choudhury 73-Plat 9:30 am FORCE-REGULATED CONFORMATIONAL CHANGES OF ΑIIBΒ3 AND ΑVΒ3 INTEGRINS: INSIGHTS FROM EQUILIBRIUM AND ENHANCED MOLECU LAR DYNAMICS SIMULATIONS. Reza Kolasangiani , Khashayar Farzanian, Martin Schwartz, Tamara Bidone 74-Plat 9:45 am DIFFERENTIAL BEHAVIOR OF CONFORMATIONAL DYNAMICS IN ACTIVE AND INACTIVE STATES OF CANNABINOID RECEPTOR 1 REVEALED BY MICROSECOND MOLECULAR DYNAMICS SIMULATION. Ugochi H. Isu , Adithya Polasa, Mahmoud Moradi 75-FlashTalk 10:00 am Travel Award Winner EXPERIMENT AND SIMULATIONS REVEAL RESIDUE DETAILS FOR HOW TARGET BINDING TUNES CALMODULIN'S CALCIUM BINDING PROPER TIES. Jules Berlin Nde Kengne , Pengzhi Zhang, Neal Waxham, Margaret S. Cheung 76-FlashTalk 10:05 am REWEIGHTING METHODS FOR ELUCIDATION OF CONFORMATIONAL ENSEMBLES OF PROTEINS. Raquel Gama Lima Costa , R. Andrew Byrd, David Fushman

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