BPS2024 Full Program & Abstracts

Platform Membrane Receptors and Signal Transduction 8:15 am - 10:15 am, Room 204C Co-Chairs Meghan Morrissey, University of California, Santa Barbara, USA Ravi Yadav, University of Southern California, USA 98-Plat 8:15 am ITRVZ: LIQUID-LIKE NANOSCALE SIGNALING PLATFORM ON THE PLASMA MEMBRANE THAT INTEGRATES RECEPTOR SIGNALS LEADING TO CANCER PROMOTION. Taka A. Tsunoyama , Christian Hoffmann, Daiki Sasaki, Bo Tang, Koichiro M. Hirosawa, Yuri L. Nemoto, Rinshi S. Ka sai, Takahiro K. Fujiwara, Kenichi G.N. Suzuki, Hiroki Ishikawa, Dragomir Milovanovic, Akihiro Kusumi 99-Plat 8:30 am SIGNALING REACTIONS IN 2D VS. 3D. William Y.C. Huang , Steven G. Boxer, James E. Ferrell 100-Plat 8:45 am NANOSCALE ORGANIZATION OF EAT ME AND DON’T EAT ME SIGNALS DURING PHAGOCYTOSIS. Wyatt Miller, Meghan Morrissey 101-Plat 9:00 am THE BIOPHYSICAL LANDSCAPE OF RECONSTITUTED IMMUNE SYNAPSES. Franziska Ragaller , Taras Sych, Luca Andronico, Adnane Achour, Erdinc Sezgin 102-Plat 9:15 am PARAMETERIZATION OF CROWDING FORCES IN THE CELL-SURFACE GLYCOCALYX. Lingting Huang , Matthew Paszek 103-Plat 9:30 am STRUCTURAL BASIS OF ANAPHYLATOXIN RECEPTOR ACTIVATION AND SIGNALING BIAS. Ravi Yadav , Manish K. Yadav, Jagannath Maharana, Shirsha Saha, Parishmita Sarma, Ramanuj Banerjee, Arun K. Shukla, Cornelius Gati 104-Plat 9:45 am USING SPRINGSALAD MESOSCALE SIMULATIONS WITH COPASI ODE PARAMETER OPTIMIZATION TO MODEL MEMBRANE-ASSOCIATED KINETICS BASED ON MEASURED VOLUMETRIC RATE CONSTANTS. Kelvin J. Peterson , Leslie M. Loew 105-FlashTalk 10:00 am CALCIUM IONS MODULATE THE ACTIVATION OF METABOTROPIC GLUTA MATE RECEPTOR BY GLUTAMATE. Sadaf Dadashkhan , Christian Sattler, Thomas Zimmer, Klaus Benndorf, Ralf Schmauder 106-FlashTalk 10:05 am SMI-FSM: MULTISCALE IMAGING AND QUANTITATIVE ANALYSIS OF PLASMA MEMBRANE PROTEINS AND CORTICAL ACTIN. Huong-Tra Ngo , Aparajita Dasgupta, Deryl Tschoerner, Nicolas Touret, Bruno da Rocha Azevedo, Khuloud Jaqaman 107-FlashTalk 10:10 am A DISRUPTIVE METHOD TO OBSERVE DIRECTLY THE DISTRIBUTION OF GPCR STATES IN LIVE CELLS. Ankur Gupta , Gabriele Kockelkoren, Jens Carstensen, Dimitrios Stamou

Career Development Center Workshop Networking for Biophysicists: How to Create Your Dream Career 9:00 am - 10:30 am, Room 108B In this session, we will discuss how to leverage networking to create a unique, customized career, which we call Your Dream Career. We will address how to understand your unique value, skills, and interests and how to align that with employers who will hire you. We will discuss various methods for finding and building win-win collaborations with people in different professions and pathways to create opportunities for your dream career to come to fruition. Meet and Greet with Black in Biophysics 9:30 am - 10:30 am, Room 105AB Exhibitor Presentation Bruker 9:30 am - 11:00 am, Room 103C The Bruker Vutara VXL: Superresolution Microscopy Multiplexed and in 3D The Bruker Vutara VXL is a dedicated single-molecule localization (SMLM) super-resolution microscope. Historically, the optical resolution limit of fluorescence microscopy constrained the study of structures smaller than 300 nm. The Vutara VXL transcends this barrier, offering an optical resolution of 20 nm and beyond, and allows the unraveling of biological enigmas that necessitate specific labeling akin to fluorescence microscopy but demand a resolution surpassing that of diffraction limited microscopy. One of the distinguishing features of the Vutara VXL is its proprietary bi-plane technology. This extends the traditional 2D fitting into the third dimension, enabling the imaging of thick cell cultures and tissue slices. The Vutara VXL does not require TIRF illumination. The Vutara VXL employs a variety of techniques to achieve super-reso lution. These include STORM, PALM, dSTORM, and DNA-PAINT. These techniques involve the modulation of dye molecule emissions and the transient binding of oligonucleotides. The result is a system capable of imaging, resolving, and quantifying cellular structures, molecular ma chines, proteins, RNA, and chromosomal structures with unprecedented detail. In addition to its super-resolution and 3D imaging capabilities, the Vutara VXL stands out for its multiplexing capabilities. It is equipped with two cameras for simultaneous multi-color imaging, allowing for the concurrent observation of multiple sub-cellular components. Further more, it integrates with the PlexFlo fluidics platform, enabling multi plexed experiments. This integration facilitates the simultaneous inves tigation of multiple biological phenomena, enhancing the efficiency and scope of research. In this presentation, we will discuss how the Bruker Vutara VXL compact bench-top system brings the power of SMLM into your lab. Speaker Winfried Wiegraebe, Product Manager Superresolution Microscopy, Bruker Exhibits 10:00 am - 5:00 pm, Exhibit Hall AB

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CPOW Committee Meeting 8:30 am - 10:30 am, Room 106AB

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