BPS2024 Full Program & Abstracts

Coffee Break 10:15 am - 11:00 am, Exhibit Hall AB Exhibitor Presentation Bruker 10:30 am - 12:00 pm, Room 113C Applications of Electron Paramagnetic Resonance (EPR) and Nuclear Magnetic Resonance (NMR) in Biophysical Research Paramagnetic species and free electrons are common in biologi cal systems, and Electron Paramagnetic Resonance (EPR) is the best method for detecting metals and free radicals in biological samples. EPR provides information on the physical and electronic structure around a paramagnetic center and can be performed in both continuous wave (CW) and Pulse formats. CW EPR provides general information on the spin center and its surroundings, while Pulse EPR offers detailed knowl edge of primary to quaternary structure. Hyperfine Spectroscopies, such as Pulse-ENDOR and HYSCORE, provide information on the hyperfine interaction and can map enzyme active sites, binding interactions, and local changes during catalysis. Site-Directed Spin Labeling (SDSL) intro duces unpaired spins into proteins, enzymes, or nucleotides, and Pulsed Dipolar Spectroscopy (PDS) measures the dipolar coupling between two spins to gain dynamic information on a larger scale. PDS can yield distance distributions, providing information on the dynamics of regions of interest and temporal resolution of the ensemble. Shaped pulses us ing Arbitrary Waveform Generator (AWG) technology have opened new avenues for researchers to improve existing experiments and design new schemes for PDS. Nuclear Magnetic Resonance (NMR) is another powerful technique for biophysical research, and Bruker BioSpin has introduced novel products to facilitate research. Bruker BioSpin continues to drive the evolution of ultra high field NMR magnets, with the completion of the first instal lation of a 1.2 GHz spectrometer on the North American continent at Ohio State University and the installation of 1.1 GHz instruments at the University of Wisconsin at Madison and the University of Georgia. Bruk er BioSpin has also introduced the HelioSmart series of Helium recovery and liquification systems to reduce helium consumption for ultra-high field magnets. On the data processing and analysis end, Bruker BioSpin has introduced deep learning-based modules in their software for better data processing and peak analysis and is collaborating with academic labs on the implementation of AI and machine learning in the analysis of NMR data. The current status of these collaborations will be presented. In summary, both EPR and NMR are powerful techniques for biophysical research, and Bruker BioSpin is at the forefront of developing and intro ducing novel products to facilitate research. From ultra-high field NMR magnets and helium recovery systems to deep learning-based modules in their software, Bruker BioSpin is committed to advancing the field of biophysical research. Speakers Clemens Anklin, Vice President, NMR Applications & Training, Bruker BioSpin Alvaro Montoya, EPR Application Scientist, Bruker BioSpin

Symposium Cardiac Plasticity or Maturation - the Cardiomyocyte's Perspective 10:45 am - 12:45 pm, Ballroom A

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Co-Chairs Cesare Terracciano, Imperial College of London, United Kingdom Nina Ullrich, University of Bern, Switzerland 108-Symp 10:45 am DEVELOPMENT AND REGULATION OF CARDIAC DYADS. William Pu No Abstract 11:10 am SINGLE-CELL MULTI-OMICS ANALYSIS TO ANALYZE CARDIOMYOCYTE PLASTICITY. Seitaro. Nomura 109-Symp 11:35 am STRUCTURAL REMODELING TRIGGERS FUNCTIONAL MATURATION OF IPSC-DERIVED CARDIOMYOCYTES. Nina D. Ullrich , Fatemeh Kermani, Jan-Mischa Sauter, Arlene Koerner, Xijian Ke, Sarah Bertels, Martin Bastmeyer 110-SympSelect 12:00 pm EFFECTS OF A HIGH-AFFINITY AND SELECTIVE RYR2 INHIBITOR ON CA 2+ SIGNALS IN CARDIOMYOCYTES AND ARRHYTHMIAS IN CPVT MODEL MICE. Nagomi Kurebayashi , Masami Kodama, Takashi Murayama, Ryosuke Ishida, Shuichi Mori, Masami Sugihara, Masato Konishi, Aya Miura, Hajime Nishio, Yukiko U. Inoue, Takayoshi Inoue, Satoru Noguchi, Hiroyuki Kagechika, Takashi Sakurai No Abstract 12:20 pm ADAPTING TO LIFE AND INJURY: PLASTICITY OF THE HEART IN HEALTH AND DISEASE. Cesare Terracciano Symposium Biophysics of Host-Pathogen Interactions and Infection Processes 10:45 am - 12:45 pm, Ballroom B Chair Effie Bastounis, University of Tübingen, Germany 111-Symp 10:45 am APICAL ADHESION OF EXTRACELLULAR BACTERIA MODULATES HOST CELL MECHANICS THROUGH A NOVEL ACTOMYOSIN STRUCTURE. Daria Bonazzi , Gautham Sankara, Sylvie Goussard, Guillaume Dumenil 112-Symp 11:10 am BACTERIA MECHANOSENSE SURFACES TO GUIDE MOTILITY AND BIO FILM FORMATION. Alexandre Persat 113-Symp 11:35 am CELLULAR MORPHOGENESIS IN PATHOGENIC FUNGI. Enrique Rojas , Maxim Ohairwe, Branka Zivanovic 114-SympSelect 12:00 pm VIRAL SPIKE-RECEPTOR INTERACTIONS MONITORED BY CRYO-ELECTRON TOMOGRAPY ON MEMBRANES. Walther Mothes , Wenwei Li, Mikey W. Grunst, Zhuan Qin, Elizabeth Nand 115-Symp 12:20 pm ERK ACTIVATION WAVES ARE KEY DRIVERS IN THE MECHANICAL CELL COMPETITION THAT LEADS TO COLLECTIVE ONSLAUGHT OF BACTERIAL LY-INFECTED CELLS. Lara Hundsdorfer, Marie Muenkel, Raul Aparicio Yuste, Maria Gómez Benito, Effie E. Bastounis

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