BPS2024 Full Program & Abstracts

Exhibitor Presentation Thermo Fisher Scientific 2:30 pm - 4:00 pm, Room 113C Achieving Cryo-EM Solutions with 100kV Data Collection To fully understand biological processes, and how they fail in disease, it is vital to obtain structural information for the relevant biological ma chinery. Notably, it is becoming increasingly apparent that proteins, the key biological players in fundamental biology or disease mechanisms, often adopt multiple conformations or act in complexes with other proteins. These large and/or dynamic systems present a challenge to traditional methods of 3D structural determination as X-ray crystallography or NMR. Fortunately, cryo-electron microscopy (Cryo-EM) techniques, particularly single particle analysis (SPA), have emerged as a well-suited approach for the determination of native protein function, the dynamics of complex biological systems, and drug discovery applications. In Cryo-EM, specimens are rapidly frozen (vitrified) so that their biologi cally relevant native states are preserved. SPA can then obtain structural details of the specimen at near-atomic resolution. This technique has transformed the field of structural biology, leading to new insight into numerous biological processes. During this seminar, Dr. Natalia de Val will talk about how cryo-EM is revolutionizing structural biology, and she will present the capabilities of our cryo-transmission electron microscope Tundra coupled with our newest Direct Electron Detector (DED) camera, Falcon-C. Our Tundra cryo-TEM is dedicated to SPA, bringing this powerful technique to every biochemistry laboratory. The Tundra Cryo-TEM is specially designed for new users who are interested in adopting electron microscopy but may not possess expertise in the field. It is easier to use than typical cryo-TEM instruments, fits into a standard lab space, and matches funding opportunities globally. The Tundra, combined with our new DED for 100kV, Falcon-C, is a powerful tool that can help answer your most challenging research questions, offering structural determina tion at biologically relevant resolutions. Speaker Natalia de Val, Senior Scientist, Electron Microscopy, Thermo Fisher Scientific Early Careers Committee Meeting 3:30 pm - 5:00 pm, Room 106AB Career Development Center Workshop Nailing the Job Talk, or Erudition Ain’t Enough 4:00 pm - 5:00 pm, Room 108B Congratulations! You've made it to the finals and are suddenly facing the most important presentation of your life. Answers to your questions about how to structure your presentation, how much detail to include, what they are really looking for, etc. Publications Committee Meeting 4:00 pm - 6:00 pm, Room 110AB

Symposium Biophysics of Cancer 4:00 pm - 6:00 pm, Ballroom A

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Chair Kandice Tanner, NCI, NIH, USA 169-Symp 4:00 pm NON-CANONICAL MECHANISMS OF MITOCHONDRIAL QUALITY CON TROL IN CANCER CELLS. Christina Towers 170-Symp 4:25 pm INVESTIGATING THE ROLES OF OLIGOMERIZATION AND LIPID INTERAC TION IN TAM RECEPTOR ACTIVATION. Chrystal Starbird , Bryanna Shao, Maria Hincapie-Otero 171-Symp 4:50 pm THE ATYPICAL RIO KINASES IN CANCER. Nicole A. LaRonde 172-SympSelect 5:15 pm METABOLIC PROFILING AND TRACKING PHENOTYPIC CHANGES IN MITOCHONDRIA IN CANCER CELLS WITH MITOMETER AND THE PHA SOR APPROACH TO FLIM. Michelle A. Digman , Giulia Tedeschi, Lorenzo Scipioni, Austin E. Lefebvre, Francesco Palomba No Abstract 5:35 pm BIOPHYSICAL REGULATION OF METASTASIS. Kandice Tanner Symposium Bioenergetics and Mitochondrial Biophysics 4:00 pm - 6:00 pm, Ballroom B Chair Angelika Rambold, Max Planck Institute of Immunobiology and Epi genetics, Germany 173-Symp 4:00 pm THE ROLE OF MITOCHONDRIAL DYNAMICS FOR CELLULAR FATE AND HOMEOSTASIS. Koen Wentinck, Sandhya Manohar, Tim Pflaesterer, Gabriel Neurohr, Tatjana Kleele No Abstract 4:25 pm NOVEL ROLES FOR THE ACTIN CYTOSKELETON IN MITOCHONDRIA DYNAMICS. Uri Manor No Abstract 4:50 pm A SPATIAL MAP OF HEPATIC MITOCHONDRIA UNCOVERS FUNCTIONAL HETEROGENEITY SHAPED BY NUTRIENT-SENSING SIGNALING. Natalie Porat-Shliom 174-SympSelect 5:15 pm MITOCHONDRIAL NUCLEOID CONDENSATES DRIVE PERIPHERAL FISSION THROUGH HIGH MEMBRANE CURVATURE. Jiajie Diao No Abstract 5:35 pm ORGA-METABOLIC NETWORKS CONTROL IMMUNE CELL FUNCTIONS. Angelika Rambold Platform TRP Channels 4:00 pm - 6:00 pm, Room 103AB Co-Chairs Candice Paulsen, Yale University, USA Eric Senning, The University of Texas at Austin, USA 175-Plat 4:00 pm STRUCTURE OF HUMAN TRPV4 IN COMPLEX WITH GTPASE RHOA. Irina A. Talyzina , Kirill D. Nadezhdin, Alexander I. Sobolevsky

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