BPS2024 Full Program & Abstracts

176-Plat 4:15 pm COUPLING ENZYMATIC ACTIVITY AND GATING IN AN ANCIENT TRPM CHANZYME AND ITS MOLECULAR EVOLUTION. Sushant Kumar , Yihe Huang, Wei Lu, Juan Du 177-Plat 4:30 pm A PAINFUL PARADOX: HOW A DRASTIC TRPA1 TRUNCATION CONFERS GAIN-OF-FUNCTION. Avnika Bali, Samantha Schaefer, Isabelle Trier, Alice L. Zhang, Lilian Kabeche, Candice E. Paulsen 178-Plat 4:45 pm STRUCTURAL BASIS OF REGULATION OF ENDOLYSOSOMAL CHANNEL TRPML2. Sunjae Park , Zhengshan Hu, Jian Yang 179-Plat 5:00 pm A HUMAN GENOME VARIANT HOTSPOT IN THE TRPV1 ANKYRIN REPEAT DOMAIN OPENS THE DOOR TO STRUCTURE-FUNCTION INSIGHT FOR A CONSERVED METHIONINE. Grace Wulffraat, Andres Jara Oseguera, Eric N. Senning 180-Plat 5:15 pm IDR CARTOGRAPHY: MAPPING REGULATORY ELEMENTS ALONG THE INTRINSICALLY DISORDERED REGIONS OF TRP ION CHANNELS. Ute A. 5:30 pm A SUICIDAL MECHANISM FOR THE EXQUISITE TEMPERATURE SENSITIVI TY OF TRPV1. Andrew Mugo, Ruan Chou, Felix Chin, Beiying Liu, Qiuxing 5:45 pm DISENTANGLING HUMAN TRPV1 POLYMODAL ACTIVATION AND MECHANISMS. Helen F. Mann , Dustin Luu, Anna-Marie Agyepong, Wade D. Van Horn 183-FlashTalk 5:50 pm BRIDGING THE GAP ON TRPV2 PHARMACOLOGY. Alex Peralvarez Marin , Eric Catalina-Hernandez, Mohsen Habibnia, Mario López-Martín 184-FlashTalk 5:55 pm Travel Award Winner A SYNTHETIC METHOD TO ASSAY POLYCYSTIN ION CHANNEL BIOPHYS ICS. Megan Larmore , Orhi Esarte Palomero, Neha P. Kamat, Paul G. DeCaen Platform Condensates and Aggregates in Physiology and Disease 4:00 pm - 6:00 pm, Room 113AB Co-Chairs Dragomir Milovanovic, Deutsches Zentrum für Neurodegenerative, Germany Macarena Siri, Max Planck Institute of Colloids and Interfaces, Germany 185-Plat 4:00 pm Travel Award Winner AMYLOID FIBERS IN BIOFILMS: STRUCTURE AND ADAPTATION TO ENVIRONMENTAL CUES. Macarena Siri , Agustín Mangiarotti, Mónica Vázquez-Dávila, Cécile M. Bidan 186-Plat 4:15 pm Travel Award Winner AFFINITY HIERARCHIES AND AMPHIPHILIC PROTEINS UNDERLIE THE CO ASSEMBLY OF NUCLEOLAR AND HETEROCHROMATIN CONDENSATES. Varsha Rajshekar , Omar Adame-Arana, Gaurav Bajpai, Samuel Safran, Gary Karpen 187-Plat 4:30 pm PHOSPHORYLATION REGULATES THE FUNCTION OF THE SARS-COV-2 NUCLEOCAPSID PROTEIN. Bruna Favetta , Huan Wang, Mayur Barai, Bineet Sharma, Cesar Ramirez, Gabriela Tirado-Mansilla, Sanjeeva Mur thy, Adam Gormley, Zheng Shi, Benjamin S. Schuster Hellmich 181-Plat Jiang, Feng Qin 182-FlashTalk

188-Plat 4:45 pm LIQUID-LIQUID PHASE SEPARATION AND ITS ROLE IN SARCOMERIC Z-DISC FORMATION. Philipp Galuska , Antonio Sponga, Kristina Djinovic Carugo 189-Plat 5:00 pm TARGETING AND MANIPULATING ENDOGENOUS TRANSCRIPTIONAL CONDENSATES. Choongman Lee , Ida Suppanz, Gerhard Mittler, Ibrahim Cisse 190-Plat 5:15 pm PHOSPHORYLATION OF HSP27 REGULATES THE FLUIDITY OF P62 PHASE CONDENSATES IN AUTOPHAGY. Elizabeth R. Gallagher , Peace T. Oloko, Erika L.F. Holzbaur 191-Plat 5:30 pm SINGLE MOLECULE IMAGING REVEALS LIQUID-LIQUID PHASE SEPARA TION AT THE SYNAPTIC BOUTONS. Christian Hoffmann, Jakob Rentsch, Taka A. Tsunoyama, Akihiro Kusumi, Helge Ewers, Dragomir Milovanovic 192-FlashTalk 5:45 pm REDOX-DEPENDENT PHASE SEPARATION AND CYTOPLASMIC GRANULA TION BY HUMAN SINGLE-STRANDED DNA BINDING PROTEIN 1 (HSSB1) POINT TO NEW MECHANISMS OF CELLULAR STRESS RESPONSE. János Pálinkás , Gabor Harami, Zoltán J. Kovács, Bálint Jezsó, Krisztián Tárnok, Hajnalka Harami-Papp, József Hegedüs, Lamiya Mahmudova, Eszter Házy, Péter Ecsédi, Nóra Kucsma, Szilárd Tóth, Gergely Szakács, Mihaly Kovacs 193-FlashTalk 5:50 pm NUCLEAR MECHANOSENSING OF CELL CONFINEMENT THROUGH BIO MOLECULAR CONDENSATES. Jessica Z. Zhao , Britt Adamson, Clifford P. Brangwynne 194-FlashTalk 5:55 pm NOVEL METHODS TO STUDY AMYLOID OLIGOMERS. Lei Ortigosa Pascual , Ewa A. Andrzejewska, Tinna Pálmadóttir, Tuomas P. Knowles, Sara Linse Platform Protein Structure, Prediction, and Design 4:00 pm - 6:00 pm, Room 201AB Co-Chairs Huong Kratochvil, University of North Carolina at Chapel Hill, USA Sahand Rahi, EPFL, Switzerland 195-Plat 4:00 pm DISSECTING FMRP DOMAINS TO RESTORE THE SYNAPTIC FUNCTION IN FRAGILE X-SYNDROME. Gloria Venturini , Ilenia Cirilli, Agnese Roscioni, Alice Romagnoli, Anna La Teana, Daniele Di Marino 196-Plat 4:15 pm DIFFERENCES IN RELEVANT PHYSICOCHEMICAL PROPERTIES CORRELATE WITH SYNERGISTIC ACTIVITY OF ANTIMICROBIAL PEPTIDES. Angela Medvedeva , Hamid Teimouri, Anatoly B. Kolomeisky 197-Plat 4:30 pm DE NOVO DESIGN OF A DNA-BINDING PROTEIN CAPABLE OF MULTI-SITE RECOGNITION. Lee A. Solomon , Jacklin Sedhom 198-Plat 4:45 pm DIRECTED EVOLUTION OF DYNAMIC, MULTI-STATE, AND COMPUTA TIONAL PROTEINS. Sahand Rahi , Vojislav Gligorovski 199-Plat 5:00 pm Travel Award Winner DEFINING THE PHYSICOCHEMICAL BASIS FOR PROTON SELECTIVITY THROUGH THE DE NOVO DESIGN OF FUNCTIONAL PROTON CHANNELS. Vincent Silverman, Gisselle Prida, Arora Rohrbach, Huong T. Kratochvil

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