BPS2024 Full Program & Abstracts

545-Pos Board B311 A DISRUPTIVE METHOD TO OBSERVE DIRECTLY THE DISTRIBUTION OF GPCR STATES IN LIVE CELLS. Ankur Gupta , Gabriele Kockelkoren, Jens Carstensen, Dimitrios Stamou 546-Pos Board B312 SMI-FSM: MULTISCALE IMAGING AND QUANTITATIVE ANALYSIS OF PLASMA MEMBRANE PROTEINS AND CORTICAL ACTIN. Huong-Tra Ngo , Aparajita Dasgupta, Deryl Tschoerner, Nicolas Touret, Bruno da Rocha Azevedo, Khuloud Jaqaman 547-Pos Board B313 ITRVZ: LIQUID-LIKE NANOSCALE SIGNALING PLATFORM ON THE PLASMA MEMBRANE THAT INTEGRATES RECEPTOR SIGNALS LEADING TO CANCER PROMOTION. Taka A. Tsunoyama , Christian Hoffmann, Daiki Sasaki, Bo Tang, Koichiro M. Hirosawa, Yuri L. Nemoto, Rinshi S. Ka sai, Takahiro K. Fujiwara, Kenichi G.N. Suzuki, Hiroki Ishikawa, Dragomir Milovanovic, Akihiro Kusumi 548-Pos Board B314 THE BIOPHYSICAL LANDSCAPE OF RECONSTITUTED IMMUNE SYN APSES. Franziska Ragaller , Taras Sych, Luca Andronico, Adnane Achour, Erdinc Sezgin 549-Pos Board B315 NANOSCALE ORGANIZATION OF EAT ME AND DON’T EAT ME SIGNALS DURING PHAGOCYTOSIS. Wyatt Miller, Meghan Morrissey 550-Pos Board B316 USING SPRINGSALAD MESOSCALE SIMULATIONS WITH COPASI ODE PARAMETER OPTIMIZATION TO MODEL MEMBRANE-ASSOCIATED KINETICS BASED ON MEASURED VOLUMETRIC RATE CONSTANTS. Kelvin J. Peterson , Leslie M. Loew 551-Pos Board B317 PARAMETERIZATION OF CROWDING FORCES IN THE CELL-SURFACE GLYCOCALYX. Lingting Huang , Matthew Paszek 552-Pos Board B318 STRUCTURAL BASIS OF ANAPHYLATOXIN RECEPTOR ACTIVATION AND SIGNALING BIAS. Ravi Yadav , Manish K. Yadav, Jagannath Maharana, Shirsha Saha, Parishmita Sarma, Ramanuj Banerjee, Arun K. Shukla, Cornelius Gati Intracellular Calcium Channels and Calcium Sparks and Waves (Boards B319 - B333) 553-Pos Board B319 ANALYSIS OF RYR2 DISTRIBUTION IN HEK293 CELLS AND MOUSE CARDIAC MYOCYTES USING 3D MINFLUX MICROSCOPY ACHIEVES ALL OPTICAL SUBUNIT RESOLUTION. Anna Meletiou , Alexander H. Clowsley, Evelina Lucinskaite, Isabelle Jansen, Peter P. Jones, William E. Louch, Christian Soeller 554-Pos Board B320 HOW DIASTOLIC CA 2+ RELEASE EVOLVES WITH INCREASING RYR ARRAY SIZE. Dirk Gillespie 555-Pos Board B321 PHARMACOLOGICAL ENHANCEMENT OF SK CHANNELS SUPPRESSES ARRHYTHMOGENIC SR CA 2+ RELEASE IN ATRIAL MYOCYTES FROM MOUSE MODEL OF CPVT. Andriy E. Belevych , Snizhana Chorna, Fruzsina Perger, Roland Veress, Radmila Terentieva, Bjorn C. Knollmann, Isabelle Deschenes, Dmitry A. Terentyev 556-Pos Board B322 SCREENING OF STATIN ANALOGUES FOR EFFECTS ON THE ACTIVITY OF THE CARDIAC RYANODINE RECEPTOR. Chris Lindsay, Jianshu Hu, Angela Russell, Charalampos Sigalas , Rebecca M. Sitsapesan

557-Pos Board B323 ABLATION OF IRBIT IN HUMAN EMBRYONIC KIDNEY CELLS REVEALS REGULATORY NETWORK. Martin Kruse , Eloise Botka, William Brown, Yueh Qi Chuah, Zachary Collester, Molly Connors, Nick Gonzalez, Kiana Keller, Ben Morse, Sydney Rastkhane, Charlotte Rubin 558-Pos Board B324 EXPLORING THE INTERPLAY BETWEEN THE EF HAND DOMAIN AND S2-S3 LOOP IN RYR1: IMPLICATIONS FOR CA 2+ /MG 2+ INHIBITION. Millar Elferdink, MacKenzie Kral, Venkat R. Chirasani, Jordan S. Carter, Savan nah Heitmann, Naohiro Yamaguchi 559-Pos Board B325 REGULATION OF SERCA2A FUNCTION BY THE SARCO/ENDOPLASMIC RETICULUM LUMINAL DOMAIN. Elisa Bovo , Roman Nikolaienko, Daniel Kahn, L. Michel Espinoza-Fonseca, Aleksey V. Zima 560-Pos Board B326 THE EFFECT OF OXIDIZED GLUTATHIONE ON RYR2 INTERSUBUNIT CROSS-LINKING AND CA REGULATION. Roman Nikolaienko , Thomas Jamrozik, Elisa Bovo, Mostafa Mostafa, Daniel Kahn, Aleksey V. Zima 561-Pos Board B327 Travel Award Winner THE HUMAN MITOCHONDRIAL MRS2 CHANNEL IS A CA 2+ -REGULATED NON-SELECTIVE CATION CHANNEL. Yung-Chi Tu , Chen-Wei Tsai, Ming Board B328 ENT -VERTICILIDE B1 INHIBITS TYPE 2 RYANODINE RECEPTOR CHAN NELS AND IS ANTIARRHYTHMIC IN CASQ2-/- MICE. Aaron Gochman , Tri Q. Do, Kyungsoo Kim, Jacob Schwarz, Madelaine P. Thorpe, Daniel Blackwell, Abigail N. Smith, Wendell S. Akers, Razvan L. Cornea, Derek R. Laver, Jeffrey N. Johnston, Bjorn C. Knollmann 563-Pos Board B329 EXPLORING THE CONSEQUENCES OF CALCIUM DYSREGULATION INDUCED BY ALZHEIMER’S DISEASE ONSET: FOCUS ON SYNAPTIC DYSFUNCTIONS. Andrea Marcantoni , Enis Hidisoglu, Giuseppe Chiantia, Valentina Carabelli, Emilio Carbone 564-Pos Board B330 LIFE-LONG CREATINE DEFICIENCY LEADS TO ADAPTATIONS IN CALCIUM HANDLING BUT NOT HEART FAILURE. Jelena Branovets , Martin Laas maa, Jekaterina Stolova, Xin Shen, Triinu Rätsepso, Mihkel Jaan Balodis, Cärolin Grahv, Eliise Hendrikson, William Edward Louch, Rikke Birkedal, Marko Vendelin 565-Pos Board B331 CARDIAC PATHOPHYSIOLOGY OF COVID-19 MEDIATED BY RYANODINE RECEPTOR TYPE 2 CA 2+ LEAK. Laith Bahlouli , Steven Reiken, Haikel Dridi, Andrew R. Marks 566-Pos Board B332 MODULATING MITOCHONDRIAL PHOSPHATE TRANSPORT SHAPES IN TRACELLULAR CA SIGNALING TO IMPACT ARRHYTHMOGENESIS. Arpita Deb, Bjorn C. Knollmann, Bin Liu 567-Pos Board B333 Travel Award Winner CALCIUM CHANNEL TARGETED MODULATORS IDENTIFIED BY FRET BASED HIGH-THROUGHPUT SCREENING. Jonathan C. Solberg, Benjamin D. Van Setters, Marzena Brinkmann, Andrew R. Thompson, Courtney C. Aldrich, Donald M. Bers, David D. Thomas, Robyn T. Rebbeck Feng Tsai 562-Pos

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