BPS2024 Full Program & Abstracts

592-Pos Board B358 A BIFUNCTIONAL ACTUATOR REVERSES NA V 1.5 DYSFUNCTION LINKED TO CARDIAC ARRHYTHMIAS. Lucile Fossier , Ryan W. Mahling, Sandra B. Gabelli, Henry M. Colecraft, Manu Ben-Johny 593-Pos Board B359 REGULATION OF CARDIAC NAV1.5 CHANNEL GATING AND DRUG BIND ING BY THE BETA-1 SUBUNIT. Michael E. O'Leary , Mohamed Chahine 594-Pos Board B360 EVIDENCE OF COOPERATIVE GATING IN MULTICHANNEL NA V 1.5 RE CORDINGS. Mikhail Tarasov , Przemysław B. Radwański 595-Pos Board B361 A BINDING SITE FOR PHOSPHOINOSITIDE MODULATION OF VOLTAGE GATED SODIUM CHANNELS DESCRIBED BY MULTISCALE SIMULA TIONS. Yie Chang Lin , Elaine Tao, James Champion, Ben Corry 596-Pos Board B362 MAPPING STRUCTURAL DISTRIBUTION AND GATING-PROPERTY IMPACTS OF DISEASE-ASSOCIATED MUTATIONS IN VOLTAGE-GATED SO DIUM AND CALCIUM CHANNELS. Amin Akbari Ahangar , Eslam Elhanafy, Hyden Blanton, Jing Li 597-Pos Board B363 PATHOGENIC GATING PORE CURRENT CONDUCTED BY AUTISM-RELATED MUTATIONS IN THE NAV1.2 BRAIN SODIUM CHANNEL. Ahmed Eltokhi , Brian N. Lundstrom, Jin Li, William A. Catterall, Tamer M. Gamal El-din 598-Pos Board B364 ELECTROPHYSIOLOGICAL CHARACTERIZATION OF NANOBODIES TAR GETING THE INACTIVATED STATE OF NAV1.7 VSD-IV. Hai M. Nguyen , Phuong T. Nguyen, Mark McCoy, Georgeon Sandrine, Shannon Gilhooly, Kayla M. Templeton, James S. Trimmer, Bruce D. Hammock, Jon T. Sack, Theanne N. Griffith, Bruno Correia, Heike Wulff, Vladimir Yarov-Yarovoy 599-Pos Board B365 STRUCTURAL, BIOPHYSICAL, AND NEUROPHYSIOLOGICAL EFFECTS OF SCN2A MUTATIONS. Syed M.A. Wafa , Ghazaleh Yazdani, Timothy A. Fenton, Christopher H. Thompson, Roy Ben-Shalom, Alfred L. George Voltage-Gated Ca Channels (Boards B366 - B381) 600-Pos Board B366 DIFFERENTIAL IMPACT OF CHANNEL DOMAINS ON CA V 2.2 (N-TYPE) CHANNEL GATING. Viktor Yarotskyy, Guofeng Gao, Blaise Z. Peterson, Keith S. Elmslie 601-Pos Board B367 ALLOSTERIC MECHANISM OF CAV3.1 INHIBITION BY Z944, A SELECTIVE T-TYPE CHANNEL ANTAGONIST. Marina Angelini , Moira McVicar, Savana Maxfield, Nicoletta Savalli, Scott A. John, Alan Neely, Antonios Pantazis, Michela Ottolia, Riccardo Olcese 602-Pos Board B368 PROBING THE MECHANISMS OF LOW-VOLTAGE ACTIVATION IN T-TYPE CAV3.1 CALCIUM CHANNELS. Marina Angelini , Moira McVicar, Savana Maxfield, Nicoletta Savalli, Scott A. John, Alan Neely, Antonios Pantazis, Michela Ottolia, Riccardo Olcese 603-Pos Board B369 UNRAVELING THE LOGIC OF THE RAD 4-STEP MECHANISM UNDERLYING PROTEIN KINASE A MODULATION OF CA V CHANNELS. Ariana C. Gavin , Henry M. Colecraft 604-Pos Board B370 EXPLORING THE ROLE OF CA V 1.2 DYSFUNCTION IN THE DEVELOPMENT OF AUTISM SPECTRUM DISORDER USING IPSC-DERIVED NEURONS. Kev in G. Herold , Moradeke A. Bamgboye, Daiana C.O. Vieira, Schuyler Brown, Deborah DiSilvestre, Josiah O. Owoyemi, Emma Gudmundsson, Ivy E. Dick

605-Pos Travel Award Winner UNDERSTANDING CACNA1A RARE DISEASE IN THE CONTEXT OF NOVEL MUTATIONS. Audra A. Kramer , Emma G. Gudmundsson, Kevin G. Her old, Deborah DiSilvestre, Roger A. Bannister, Ivy E. Dick 606-Pos Board B372 CALCIUM-DEPENDENT ALTERATIONS IN CA V 1.2 LEAD TO A LONG QT PHENOTYPE IN INDUCED PLURIPOTENT STEM CELL-DERIVED CARDIO MYOCYTES. Schuyler Brown , Moradeke A. Bamgboye, Daiana C.O. Vieira, Deborah DiSilvestre, Josiah O. Owoyemi, Emma Gudmundsson, Ivy E. Dick 607-Pos Board B373 INVESTIGATING LQT8 MUTATIONS IN INDUCED PLURIPOTENT STEM CELL DERIVED CARDIOMYOCYTE. Daiana C.O. Vieira , Josiah O. Owoy emi, Deborah DiSilvestre, John W. Hussey, Schuyler G. Brown, Emma G. Gudmundsson, Ivy E. Dick 608-Pos Board B374 NEXT-GENERATION OPTOGENETIC ACTUATORS OF VOLTAGE-GATED CA2+ CHANNELS. Audrey Lauris Kochiss , Srinidhi Jayaraman, Pedro J. del Rivero Morfin, Nourdine Chakouri, Ryan W. Mahling, Lucile Fossier, Manu Ben-Johny 609-Pos Board B375 ROLE OF THE CHARGE TRANSFER CENTER AS A BIMODAL REGULATOR OF VOLTAGE-DEPENDENCE AND KINETICS OF CA V VOLTAGE SENSORS ACTION. Martin C. Heiss , Monica L. Fernandez-Quintero, Simone Peliz zari, Yousra El Ghaleb, Marta Campiglio, Petronel Tuluc, Klaus R. Liedl, Bernhard E. Flucher 610-Pos Board B376 THE EXTRACELLULAR S3-S4 LOOP OF CA V 1.1 VOLTAGE-SENSORS AS SPE CIFIC MODULATOR OF EC COUPLING AND CALCIUM CURRENTS. Simone Pelizzari , Monica L. Fernandez-Quintero, Marta Campiglio, Martin C. Heiss, Yousra El Ghaleb, Petronel Tuluc, Bernhard E. Flucher 611-Pos Board B377 CHARACTERIZING THE ROLE OF VOLTAGE-SENSING DOMAINS OF CAV3.3 DETERMINING GATING PROPERTIES. Anna-Lena M. Fischer , Martin C. Heiss, Yousra El Ghaleb, Johannes R. Löffler, Klaus R. Liedl, Bernhard E. Flucher, Monica L. Fernandez-Quintero 612-Pos Board B378 MECHANISM FOR PRESERVATION OF CONE PATHWAYS IN THE ABSENCE OF CA V 1.4 CA 2+ SIGNALS. Amy Lee , J. Wesley Maddox, Gregory Orde mann, Juan A. de la Rosa, Angie Huang, Christof Gault, Serena Wisner, Daiki Futagi, Steven DeVries, Mrinalini Hoon 613-Pos Board B379 Travel Award Winner SELECTIVE G-PROTEIN INHIBITION OF CAV2.2 (N-TYPE) CALCIUM CHAN NEL VOLTAGE-SENSOR DOMAINS. Michelle Nilsson , Kaiqian Wang, Teresa Mínguez Viñas, Stina Berglund, Antonios Pantazis 614-Pos Board B380 COCAINE INDUCES LOCOMOTOR SENSITIZATION THROUGH A DOPA MINE- DEPENDENT VTA-MPFC-FRA CORTICO-CORTICAL PATHWAY IN MALE MICE. Zhuan Zhou 615-Pos Board B381 STRUCTURE OF AN EMC CHAPERONE:CA V COMPLEX REVEALS AN ION CHANNEL ASSEMBLY INTERMEDIATE AND A HOLDASE FUNCTION FOR THE EMC. Zhou Chen , Abhisek Mondal, Fayal Abderemane-Ali, Seil Jang, Sangeeta Niranjan, José L. Montaño, Balyn W. Zaro, Daniel L. Minor Board B371

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