BPS2024 Full Program & Abstracts

Skeletal Muscle Mechanics, Structure, and Regulation (Boards B407 - B424) 641-Pos Board B407 IMMATURE SKELETAL MYOTUBES ARE EFFECTIVE IN IMPROVING CA 2+ RELEASE FOR SKELETAL MUSCLE CONTRACTION IN SKELETAL MYO TUBES. Seung Yeon Jeong , Jun Hee Choi, Jooho Kim, Eun Hui Lee 642-Pos Board B408 A BRANCHED-PATHWAY MODEL FOR PHOSPHATE EXPLAINS LOAD DEPENDENT INTERACTIONS OF MINI MYOSIN ENSEMBLES WITH ACTIN. Daniel J. Petersen , Christopher Marang, Edward P. Debold, Sam Board B409 IS DROSOPHILA INDIRECT FLIGHT MUSCLE A GOOD MODEL TO INVES TIGATE RESIDUAL FORCE ENHANCEMENT WITH MINIMAL SARCOMERE LENGTH NON-UNIFORMITIES? Shuyue Liu , Venus Joumaa, Tim Leonard, Walter Herzog 644-Pos Board B410 LINKING THE GLU150ALA MUTATION IN SLOW SKELETAL MUSCLE TPM3.12 TO CONGENITAL MYOPATHY. Olga E. Karpicheva , Mariia V. Tishkova, Yurii S. Borovikov, Charles S. Redwood, Michael J. Rynkiewicz, William Lehman 645-Pos Board B411 DO AGING-RELATED POST-TRANSCRIPTIONAL MYOSIN MODIFICATIONS CONTRIBUTE TO SARCOPENIA? Alon Brown , Amy K. Loya, William Kro net, Sanford Bernstein, Douglas M. Swank 646-Pos Board B412 Travel Award Winner HCM AND DCM ASSOCIATED TNNT2 SARCOMERIC VARIANTS INDUCE DIVERGENT NUCLEUS REMODELING IN HUMAN IPSC-CMS. Isabella Leite Coscarella , Lili Wang, Prescott B. Chase, Bjorn C. Knollmann, John T. Hinson, Jerome Irianto, J. Renato Pinto 647-Pos Board B413 INVESTIGATING SEGMENTAL MECHANICS OF TITIN IN IMMUNOFLUO RESCENT-LABELLED MYOFIBRILS. Chris Tiessen , Armaan Sekhon, Tim Leonard, Walter Herzog 648-Pos Board B414 TITIN ORGANIZATION IN THE BARE ZONE OF THE THICK FILAMENT OF VERTEBRATE STRIATED MUSCLE. Pauline Bennett, Martin Rees, Ay Lin Kho, Robert C. Muirhead, Davide Tamborrini, Stefan Raunser, Mathias Gautel 649-Pos Board B415 Travel Award Winner DOES TITIN CLEAVAGE ELIMINATE PASSIVE FORCE AND SARCOMERIC STRUCTURE INTEGRITY IN SINGLE MYOFIBRILS? Seong-won Han , Wolf gang A. Linke 650-Pos Board B416 Travel Award Winner STRUCTURAL AND FUNCTIONAL EFFECTS FOLLOWING LOSS OF FMYBP C IN ACTIVE SKELETAL MUSCLE. Nichlas M. Engels , Rachel Sadler, Michel Kuehn, Devin Nissen, Weikang Ma, Thomas C. Irving, Wolfgang A. Linke, Anthony L. Hessel, Samantha Harris 651-Pos Board B417 CHARACTERIZATION OF THREE-DIMENSIONAL ENGINEERED HUMAN SKELETAL MUSCLE AT DIFFERENT SCALES. Tianxin Cao , Eric Finnemore, Seunggyu Kim, Roger D. Kamm, Curtis R. Warren Walcott 643-Pos

652-Pos Board B418 MYOSIN STORAGE MYOPATHY MUTATIONS DISRUPT STRIATED MUSCLES IN DROSOPHILA AND THE MYOSIN TAIL-TAIL INTERACTOME OF HUMAN CARDIAC THICK FILAMENTS. Meera C. Viswanathan, Debabrata Dutta, William A. Kronert, Kripa Chitre, Raul Padron, Roger Craig, Sanford I. Bernstein, Anthony Cammarato 653-Pos Board B419 SKELETAL MUSCLE FUNCTION IS ALTERED IN MALE MICE ON LOW DOSE ANDROGEN RECEPTOR ANTAGONIST OR ESTROGEN RECEPTOR AGO NIST. Brent Momb , Gillian Szabo, Joshua Mogus, Stuart Chipkin, Laura Vandenberg, Mark S. Miller 654-Pos Board B420 DISTINCT SKELETAL MUSCLE FIBER-TYPE CONTRACTILE RESPONSE TO FATIGUE AT 37°C IN OLDER ADULTS. Brent Momb , Stuart Chipkin, Jane A. Kent, Mark S. Miller 656-Pos Board B422 ASSESSING THIN FILAMENT LENGTHS IN YOUNG HEALTHY HUMAN SKELETAL MUSCLE - A ROLE FOR FIBER TYPE? Alex M. Noonan , Stepha nie Khuu, Andrew D. McCulloch, Samuel R. Ward 657-Pos Board B423 PULSATILE PERMEABILIZED SLOW-TWITCH SKELETAL MUSCLE FIBERS FROM KNOCK-IN MICE CARRYING A SMYBP-C E248K PATHOGENIC VARI ANT: POTENTIAL FOR A MYOFILAMENT PACEMAKER THAT INITIATES MYOGENIC TREMORS. Laurin M. Hanft , Jennifer Mariano, Aikaterini Kontrogianni-Konstantopou, Kerry S. McDonald 658-Pos Board B424 DIFFERENTIAL DISPLACEMENT OF IMMUNOFLUORESCENT MARKERS IN SARCOMERIC TITIN DURING HISTORY DEPENDENT PROPERTIES. Armaan Sekhon , Chris Tiessen, Tim Leonard, Walter Herzog Smooth Muscle and Cardiac Muscle Regulation (Boards B425 - B434) 659-Pos Board B425 PROCUREMENT AND PRESERVATION OF NEONATAL PORCINE CARDIAC TISSUE. Lauren M. Gilbertsen 660-Pos Board B426 BAG3 DIFFERENTIALLY RESPONDS TO ACUTE AND CHRONIC STRESS VIA A POST-TRANSCRIPTIONAL MECHANISM. Laura A. Sherer , Thomas Martin, Michaela Door, Jonathan A. Kirk 661-Pos Board B427 RELATIVE EXPRESSION OF THE N2B AND N2BA ISOFORMS OF TITIN DOES NOT CHANGE MARKEDLY IN HEART FAILURE WITH REDUCED EJECTION FRACTION IN HUMANS. Austin Wellette-Hunsucker , Utku Gulbulak, Gregory Milburn, Vedant Gupta, Kenneth Campbell 662-Pos Board B428 Travel Award Winner AI-ENABLED STOCHASTIC MODEL FOR PREDICTING MUTATION EFFECTS ON CARDIAC SARCOMERE CONTRACTION. Yasser Aboelkassem 663-Pos Board B429 USING SYNTHETIC THICK FILAMENTS MADE FROM DNA TO MODEL THE REGULATION OF Β-CARDIAC MYOSIN MOTILITY BY CMYBP-C. Ianna S. Debrunner , Gde Bimananda M Wisna, Sebastian Duno-Miranda, Rizal F. Hariadi, Christopher M. Yengo, David M. Warshaw, Sivaraj Sivaramak rishnan 664-Pos Board B430 LOADED SARCOMERE SHORTENING IN PERMEABILIZED CARDIAC MYOCYTES: ROLE OF CARDIAC MYOSIN BINDING PROTEIN-C (CMYBP C). Kerry S. McDonald , Theodore J. Kalogeris, Adam B. Veteto, Daniel J. Davis, Laurin M. Hanft

F R I D A Y

S U N D A Y

44