BPS2024 Full Program & Abstracts

Platform Ligand-Gated, Anion, and Other Channels I 8:15 am - 10:15 am, Room 204AB

Platform Biosensors and Biosurfaces 8:15 am - 10:15 am, Room 201C

M O N D A Y

Co-Chairs Stephanie Heusser, University of Copenhagen, Denmark Rebecca Howard, Stockholm University, Sweden 886-Plat 8:15 am Travel Award Winner STRUCTURAL DETERMINANTS, PATHWAYS, AND ENERGETICS OF GABA BINDING AND UNBINDING TO THE GABA A RECEPTOR. Ayobami Di yaolu , Peter Obi, Ramya Chandar Charles Maria Soosai, Senthil Natesan 887-Plat 8:30 am ROLE OF M2-M3 LINKER BACKBONE-TO-BACKBONE HYDROGEN BONDS IN Α1Β2Γ2L GABA A RECEPTOR GATING. Cecilia M. Borghese , Anvita Bhatt, Jason D. Galpin, Christopher A. Ahern, Marcel P. Goldschen-Ohm 888 -Plat 8:45 am LIGAND-GATED ION CHANNEL MODULATION BY STIMULANT DERIVA TIVES VIA A VESTIBULAR CAVITY. Emelia Karlsson , Olivia Andén, Chen Fan, Zaineb Fourati, Ahmed Haouz, Yuxuan Zhuang, Marc H. Delarue, Rebecca J. Howard, Erik R. Lindahl 889 -Plat 9:00 am REVISITING THE GLYCINE RECEPTOR SIGNAL TRANSDUCTION AND PHARMACOLOGY. Pierre-Jean Corringer , Sophie Shi, Adrien Cerdan, Laurie Peverini, Solene N. Lefebvre, Paula Milán Rodríguez, Jean-Pierre Changeux, Marco Cecchini 890 -Plat 9:15 am CONFIRMATORY AND ILLUMINATING INVESTIGATION OF CRUSTACEAN NMDA RECEPTORS. Oksana Sintsova , Yuhong Wang, Timothy Lynagh 891-Plat 9:30 am Travel Award Winner MECHANISMS OF ACTIVATION AND DESENSITIZATION IN ACID-SENSING ION CHANNELS. Stephanie A. Heusser , Debayan Sarkar, Iacopo Gal leano, Caroline Marcher Holm, Asli B. Topaktas, Stephan A. Pless 892 -Plat 9:45 am MOLECULAR PHARMACOLOGY OF THE P2X7 RECEPTOR REVEALED BY CRYO-EM. Adam C. Oken , Nicolas E. Lisi, Ipsita Krishnamurthy, Alanna E. McCarthy, Michael H. Godsey, Steven E. Mansoor 893 -FlashTalk 10:00 am STRUCTURE AND DYNAMICS OF DIFFERENTIAL LIGAND BINDING IN THE HUMAN RHO-TYPE GABA A RECEPTOR. John Cowgill, Chen Fan, nandan haloi, Yuxuan Zhuang, Rebecca J. Howard , Erik Lindahl 894 -FlashTalk 10:05 am INHIBITION OF amPA-SUBTYPE IONOTROPIC GLUTAMATE RECEPTORS. William D. Hale , Alejandra Montaño Romero, Lucas Dillard, Albert Y. Lau, Richard Huganir, Edward C. Twomey 895-FlashTalk 10:10 am Travel Award Winner COMPUTATIONAL CHARACTERIZATION OF THE BINDING OF ALLOSTERIC POTENTIATORS TO THE Α4-Α4 INTERFACE OF THE Α4Β2 LS NICOTINIC ACETYLCHOLINE RECEPTOR. Franco Viscarra , Philip C. Biggin, Isabel Bermudez

Co-Chairs Matteo Dal Peraro, Swiss Federal Institute of Technology Lausanne, Switzerland Katherine Xiang, Harvard University, USA 896-Plat 8:15 am MECHANISM OF MAGNETIC FIELD-DEPENDENT PHOTOSWITCHING IN A FLUORESCENT PROTEIN. Katherine M. Xiang , Hana Lampson, Mad eleine Howell, Rebecca Frank Hayward, Daniel G. Itkis, F. Phil Brooks III, Adam E. Cohen 897-Plat 8:30 am HIGH-PERFORMANCE SENSOR DESIGN FOR GREATER INSIGHT INTO ENDOGENOUS SIGNALING MICRODOMAINS. Sohum Mehta , Anne C. Lyons, Klaus Yserentant, Kibeom Hong, Kimmy Kuang, Bo Huang, Jin Zhang 898 -Plat 8:45 am FLUORESCENT NUCLEOTIDES AND CIRCULAR RNA FOR THE IDENTI FICATION AND QUANTIFICATION OF RNA MODIFICATIONS. Melissa M. Scanlon , Kevin M. Bardon, amr K. Makhamreh, Yvonne Yee, Meni Travel Award Winner EXPLORING THE POTENTIAL OF GRAPHENE FIELD-EFFECT TRANSISTORS IN BIOSENSING FOR HEALTH AND ENVIRONMENT. Jesmina Rexha , Nunzio Perta, Alice Romagnoli, Elisa Cappetta, Michele Guescini, Daniele Di Marino 900 -Plat 9:15 am A BIOHYBRID MECHANOSENSOR INTEGRATED WITH A SOFT ROBOT. Nathan Zimmerer , Richard Desatnik, Michael Bennington, Victoria Webster-Wood, Carmel Majidi, Philip R. LeDuc 901-Plat 9:30 am SINGLE-MOLECULE SENSING WITH AEROLYSIN PORE-FORMING TOXINS. Matteo Dal Peraro 902 -Plat 9:45 am INTERPRETING AND MODELING NANOPORE IONIC CURRENT SIGNALS DURING UNFOLDASE-MEDIATED TRANSLOCATION OF SINGLE PROTEIN MOLECULES. Daphne Kontogiorgos-Heintz , Keisuke Motone, Jeff Nivala 903 -FlashTalk 10:00 am RAPID SYNTHESIS OF DE NOVO Β-BARREL PEPTIDE NANOPORES USING CELL-FREE EXPRESSION. Shoko Fujita , Izuru Kawamura, Ryuji Kawano 904 -FlashTalk 10:05 am KINETO-OPTICAL FINGERPRINTING FOR MULTIPLEXED DETECTION OF MICRO-RNAS. Pavel Banerjee, Sujay Ray , Liuhan dai, Erin Sandford, Shankarr Mandal, Muneesh Tewari, Nils G. Walter 905-FlashTalk 10:10 am TUNABLE DIGITAL GENETICALLY ENCODED TENSION SENSORS BASED ON ENGINEERED PROTEINS. Shuhong Liu Wanunu 899 -Plat 9:00 am

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