BPS2025 Full Program

2919-Pos Board B383 DESIGN OF A MINIATURIZED FLUIDIC CELL FOR SUSPENDED LIPID BILAYER MEMBRANE FORMATION AND ELECTROPHYSIOLOGICAL RE CORDINGS. Alessandro Porro , Leon Juarez, Federico Giuseppe Amodeo, Federico Thei Smooth Muscle and Cardiac Muscle Mechanics and Structure (Boards B384 - B416) 2920-Pos Board B384 DEFINING THE STRUCTURE AND ORIENTATION OF THE N TERMINAL DOMAIN OF CARDIAC TROPONIN T. Grace Heffernon , Romi Castillo, Jil C. Tardiff, Bai Hei, Ananya Chakraborti, Krishna Ghanta, Steven D. Schwartz 2921-Pos Board B385 TARGETING THE N-TERMINUS OF CARDIAC TROPONIN I TO IDENTIFY SMALL MOLECULES THAT MODULATE DIASTOLIC PERFORMANCE. Romi Castillo , Jil C. Tardiff 2922-Pos Board B386 IN VIVO ROLE OF THE UNIQUE N-HELIX OF VERTEBRATE TROPONIN C IN CARDIAC MUSCLE FUNCTION AND REGULATION. Yun Shi , Michael O. Assibey, Huan He, Maicon Landim-Vieira, Weikang Ma, Thomas C. Irving, Bradley S. Gordon, Vitold E. Galkin, J. Renato D. Pinto, Prescott B. Chase 2923-Pos Board B387 TROPOMYOSIN SNAPBACK ON ACTIN AFTER MYOSIN DETACHMENT FROM CARDIAC THIN FILAMENTS. William Lehman , Olga E. Karpicheva, Michael J. Rynkiewicz 2924-Pos Board B388 THE STRUCTURE OF NATIVE CARDIAC THIN FILAMENT CARRYING TRO PONIN T ILE79ASN PATHOGENIC VARIANT REVEALS THE ROLE OF TNT1 LOOP IN THIN FILAMENT REGULATION. Cristina M. Risi, Maicon Landim - -Vieira, Prescott B. Chase, J. Renato D. Pinto, Vitold E. Galkin 2925-Pos Board B389 TROPONIN I C-TERMINUS STRUCTURAL DYNAMICS IN THE NATIVE CAR DIAC THIN FILAMENT REVEALED BY CRYO ELECTRON MICROSCOPY. Cris tina M. Risi , J. Renato D. Pinto, Prescott B. Chase, Vitold E. Galkin 2926-Pos Board B390 Travel Award Winner SCREENING SINGLE NUCLEOTIDE CHANGES TO TROPOMYOSIN TO IDENTIFY NOVEL CARDIOMYOPATHY MUTANTS. Jian Wen , Stuart G. Campbell, Jeffrey R. Moore, William Lehman, Michael J. Rynkiewicz 2927-Pos Board B391 SKELETAL MUSCLE ACTIN MUTATION R256H DISRUPTS CARDIAC AND SKELETAL MUSCLE BIOMECHANICS BY AFFECTING MULTIPLE ACTIN FUNCTIONS AS DEMONSTRATED BY MULTISCALE ANALYSIS. Ankit Garg , Silvia Jansen, Gretchen A. Meyer, Lina Greenberg, Vivek P. Jani, Axel J. Fenwick, Rui Zhang, David A. Kass, Kory J. Lavine, Anthony Cammarato, Michael J. Greenberg 2928-Pos Board B392 DRUG EFFECTS IN TRANSGENIC MOUSE MODELS OF HYPERTROPHIC CARDIOMYOPATHY MAY BE MUTATION-SPECIFIC. Marica Dente , Lo renzo Santini, J. Manuel Pioner, Chiara Palandri, Jil C. Tardiff, Pieter P. de Tombe, Chiara Tesi, Corrado Poggesi, Cecilia Ferrantini, Raffaele Coppini 2929-Pos Board B393 FUNCTIONAL ASSESSMENT OF RECOMBINANT HUMAN ALPHA-CARDIAC MYOSIN AND THE EFFECT OF ATRIAL ARRHYTHMIA MUTATIONS. Asmita D. Pawar, Seiji C. Yokota, James A. Spudich, Kathleen Ruppel, Masataka Kawana

2930-Pos Board B394 DIFFERENTIAL MODULATION OF BETA-CARDIAC MYOSIN CONFORMA TIONS BY CARDIOMYOPATHY-ASSOCIATED MUTATIONS IN THE CON VERTER DOMAIN. Jinghua Ge , Sebastian Duno-Miranda, Arun Kumar Somavarapu, Skylar M.L. Bodt, Ruchi Gautam Sharma, Samantha Beck Previs, Angela Ploysangngam, Roger Craig, Raul Padron, David M. War shaw, Christopher M. Yengo 2931-Pos Board B395 THE DILATED CARDIOMYOPATHY-ASSOCIATED MYH7 MUTATION R369Q ALTERS SPECIFIC FORCE AND RELAXATION KINETICS IN A HU MAN INDUCED PLURIPOTENT STEM CELL-DERIVED CARDIOMYOCYTE MODEL. Aditi M. Prabhala , Tim McMillen, Matthew C. Childers, Kerry Y. Kao, William Lehman, Michael Regnier 2932-Pos Board B396 HOMOLOGOUS MUTATIONS IN MYH6 AND MYH7 DIFFERENTIALLY AFFECT CARDIAC MOTOR FUNCTION AT THE MOLECULAR SCALE. Brent Scott , Ariana Combs, Steve Langer, Leslie Leinwand, Michael J. Green berg 2933-Pos Board B397 HYDROSTATIC PRESSURE MODULATES CELLULAR CONTRACTILITY IN MOUSE CARDIOMYOCYTES. Yohei Yamaguchi , Toshiyuki Kaneko, Cho Kachi, Keisei Murata, Gentaro Iribe, Masayoshi Nishiyama, Susumu Ohya 2934-Pos Board B398 R451G DESMOPLAKIN INDUCES CONTRACTILE DEFICITS IN ENGINEERED HEART TISSUE. Ilhan Gokhan , Alex J. Mora Pagan, Stuart G. Campbell 2935-Pos Board B399 CALMODULIN ENHANCES CARDIAC MUSCLE ACTIVATION AND MAY PLAY A ROLE IN THICK FILAMENT ACTIVATION. Ronnie Chastain , Maicon Landim-Vieira, Vivek P. Jani, Weikang Ma, Paul M. Janssen, Jolanda van der Velden, Thomas C. Irving, Prescott B. Chase, Vasco Sequeira, J. Renato D. Pinto, Christopher N. Johnson 2936-Pos Board B400 THERAPEUTIC EFFECTS OF ZANTHOXYLI PERICARPIUM ON INTESTINAL INFLAMMATION AND NETWORK PHARMACOLOGICAL MECHANISM ANALYSIS IN A DSS-INDUCED COLITIS MOUSE MODEL. Woo-Gyun Choi, Daehwa Jung, Sang Chan Kim, Na Ri Choi, Byung Joo Kim 2937-Pos Board B401 DELETING A SINGLE TITIN A-BAND DOMAIN (A109) ALTERS THICK FILAMENT STRUCTURE AND FUNCTION IN STRIATED MUSCLE. Johan Lindqvist , Shane R. Nelson, Paola Tonino, Jochen Gohlke, John E. Smith, David M. Warshaw, Henk L. Granzier 2938-Pos Board B402 TITIN EXTENSIBILITY IN THE A-BAND OF INTACT SKELETAL MUSCLE. Mei hua Guo, Henry M. Gong, Eun-Jeong Lee, Balazs Kiss, Thomas C. Irving , Henk L. Granzier, Weikang Ma 2939-Pos Board B403 TITIN ISOFORMS AND STRUCTURAL LAYOUT IN THE CARDIAC SARCO MERE OF MARFAN-SYNDROME PATIENTS. Dalma Kellermayer, Cristina M. Sulea, Kalman Benke, Miklos Polos, Bence Agg, Mate Csonka, Hedvig Tordai, Tamas Radovits, Bela Merkely, Zoltan Szabolcs, Miklos Keller mayer, Balazs Kiss 2940-Pos Board B404 MECHANICAL UNLOADING INCREASES PHOSPHORYLATION OF SARCOMERIC PROTEINS AND N2B TITIN IN PATIENTS WITH HEART FAILURE. Gregory Milburn , Austin G. Wellette-Hunsucker, Florence D. Mumbi, Andrew Yackzan, Utku Gulbulak, Thomas Kampourakis, Kenneth S. Campbell

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