BPS2025 Full Program

Room 404AB: Tuesday, February 18 9:30 AM – 11:00 AM Nuclera Accelerating Protein Production: Leveraging eProtein Discovery™ for Rapid Screening and Biophysical Analysis in Drug Discovery In this 30-minute session, we’ll explore advanced methods in recombinant protein screening, scale-up, and biophysical analysis to streamline protein production workflows. We’ll discuss innovative technology that enables rapid, medium-throughput screening of recombinant proteins, assessing quality and functionality with speed and precision. By leveraging these tools, researchers can efficiently scale up protein production to meet the demands of diverse biophysical applications. Using eProtein Discovery’s integration with SPR binding analysis as an example, we’ll demonstrate how this approach can accelerate timelines and improve the workflow from initial screening to biophysical analysis, ultimately supporting drug discovery efforts with faster and more reliable protein data. Roundtable discussion will explore how these proteins can be used in advanced biophysical techniques to unlock insights into molecular interactions and mechanisms. In this open table discussion experts will delve into the specific requirements for successful biophysical analysis, including the quantity, purity, and stability of proteins needed for different techniques. Speaker Aujan Mehregan, Inside Sales Manager BD & Sales, Nuclera Room 406AB: Sunday, February 16 10:30 AM – 12:00 PM Sophion Bioscience A/S Recent Advances in Automated Patch Clamp Assays with QPatch, QPatch Compact, and Qube Systems Effective ion channel drug discovery demands the seamless integration of advanced technologies and streamlined workflows. Sophion Bioscience is at the forefront of automated patch clamp technology, offering innovative solutions for low, medium, and high throughput applications tailored for both industry and academia. Our QPatch and Qube systems are fully automated, while the QPatch Compact system offers a semi-automated option, providing flexibility for a range of research needs. With the QPatch and Qube, researchers can perform 8, 16, 48, or up to 384 parallel patch clamp recordings, supported by sophisticated computer-controlled liquid handling and on-board cell handling capabilities in the automated models. The QPatch Compact, a more hands-on system, allows for individual or simultaneous recordings across 8 channels, enabling precise control and adaptability in experiments. Sophion’s platforms deliver robust, reliable workflows for ion channel and electrophysiology applications, accelerating the discovery and development of therapeutics targeting ion channels.

Join us for a workshop where speakers will explore practical applications of the QPatch, QPatch Compact, and Qube systems in drug discovery, offering valuable insights into optimizing ion channel research through these cutting-edge tools. Speaker Daniel Sauter, Application Science Manager, Sophion Bioscience A/S 12:30 PM – 2:00 PM HORIBA Introducing the InverTau Confocal FLIM Platform and Novel Applications Using the FLIMera Lifetime Camera Fluorescence Lifetime Imaging Microscopy (FLIM) is an advanced imaging technique that measures the decay rate, or “lifetime,” of fluorescent molecules in a sample, and provides a temporal dimension for added contrast to fluorescent intensity. This unique approach makes FLIM especially valuable for studying complex biological and chemical environments, as it provides insights that are independent of fluorophore concentration. With FLIM’s booming demand, researchers are in need of faster acquisitions to accurately capture biological dynamics, and more affordable instrumentation so that FLIM can be accessible to more nuanced applications. To address these needs, Horiba has introduced the InverTau confocal laser scanning FLIM platform that provides high-end specifications at low-end pricing along with the FLIMera first-to-market SPAD array camera that is capable of true TCSPC on per pixel basis providing FLIM data at video-rates. In this presentation we will review the specifications of the new InverTau confocal FLIM system and how it applies to common FLIM applications such as protein-protein interactions (FRET), diffusion studies (FCS), molecular environmental sensitivity (pH, ion concentration, oxygen levels, etc.), and non-invasive label free imaging. We will also review the FLIMera TCSPC camera and discus novel applications using this first of its kind device including real-time monitoring of blood flow using TD-NIRS, contaminant analysis via light scatter, and imaging opaque substances using time-slicing techniques. Speaker Ross Keyashian, North American Fluorescence Imaging Product Manager, HORIBA

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