BPS2025 Full Program

Membrane Receptors and Signal Transduction (Boards LB56 - LB61) Board LB56 STRUCTURAL INSIGHTS AND COMPUTATIONAL DESIGN OF LIGAND MEDIATED FUNCTIONL RECOVERY IN MUTANT FOLLICLE-STIMULANT HORMONE RECEPTORS. Eduardo Jardón-Valadez , Teresa Zariñan, Selvaraj Nataraja, Henry N. Yu, Alfredo Ulloa-Aguirre L3118-Pos Board LB57 OXYSTEROLS MODULATE PROTEIN-STEROL INTERACTIONS TO IMPAIR CXCR4 SIGNALLING IN AGING CELLS. Surayma Asthana, Anant Verma, Baivabi Bhattacharya, Arnab Nath, Nithin Sajeev, Kiran Maan, Raji R. Nair, Ganapathy Ayappa , Deepak K. Saini L3119-Pos Board LB58 VEGF-MEDIATED REGULATION OF INTRACELLULAR CALCIUM DYNAMICS IN RESPONSE TO THERMAL STRESS. Nanako Funaki L3120-Pos Board LB59 AN OPIOID EFFICACY SWITCH FOR REVERSIBLE OPTICAL CONTROL OF PERIPHERAL ANALGESIA. Giovanna R. Romano , Luca Posa, Xiang Ji, Saif Khan, Bruno M. Paz, Gye Won Han, Antonina Nazarova, Saheem A. Zaidi, Mohsen Ranjbar, Kristen Pleil, Vsevolod Katritch, Cornelius Gati, Dirk Trauner, Josh T. Levitz L3121-Pos Board LB60 ROR2/FZR ACTIVATION BY WNT5A REGULATES PHOSPHOLIPIDS METABO LISM THROUGH DVL/GQ PROTEIN INTERACTION. Raul Riquelme , Andres Barria L3122-Pos Board LB61 T CELL RECEPTOR PROOFREADS ANTIGEN BY PARALLEL REACTIONS AND INTEGRATION. Shumpei Morita , Jay T. Groves Calcium Signaling (Boards LB62 - LB64) L3123-Pos Board LB62 A PSEN2 VARIANT P.N141I FOUND IN EARLY-ONSET ALZHEIMER’S DISEASE CAUSES ABERRANT CA 2+ WAVES IN HUMAN IPS CELL DERIVED NEURON. Haruka Inaba , Atsushi Hori, Wado Akamatsu, Takashi Miida, Tomohiko Ai L3124-Pos Board LB63 DEFINING THE ORAI1-STIM1 BINDING INTERFACE. Megumi Yamashita , Murali Prakriya L3125-Pos Board LB64 PERMEANT MONOVALENT CATIONS MODULATE THE GATING OF CALCI UM-FREE CRAC CHANNELS. Suzanna M. Bennett , Richard S. Lewis Muscle Regulation (Boards LB65 - LB68) L3126-Pos Board LB65 TRANSCRIPTIONAL AND FUNCTIONAL CHARACTERIZATION OF MAVACAM TEN IN PORCINE AND HUMAN MYOCARDIAL MODELS OF HYPERTROPHIC CARDIOMYOPATHY. Natalie Weber , Elisa Kiselev, Wilson Agyapong, Elisa Mohr, Angelika Pfanne, Yiangos Psaras, Christopher N. Toepfer, Ante Rado caj, Andre Zeug, Arjang Ruhparwar, Ke Xiao, Christian Baer, Thomas Thum L3127-Pos Board LB66 SARCOMERE LENGTH AND FORCE BEHAVIOR IN SKELETAL MUSCLE MYOFI BRILS. Taiki Ino L3128-Pos Board LB67 FAST SKELETAL MYOSIN INHIBITOR EDG-4131 UNCOUPLES THE STRUC TURAL OFF-STATE AND FUNCTIONAL SUPER-RELAXED STATE IN RESTING MUSCLE. Sarah Lehman , Weikang Ma, Mike DuVall, Ying Qian, Breanne N. Stamper, Lindsey Lee, Ben Barthel, Molly Madden, Marc Evanchik, Thomas C. Irving, Alan J. Russell L3117-Pos

L3129-Pos Board LB68 COMPARING LENGTH-DEPENDENT ACTIVATION IN THE HUMAN LEFT VEN TRICLE AND LEFT ATRIUM. Alexandre Lewalle , Gregory Milburn, Jania Bell, Kenneth S. Campbell, Steven A. Niederer Voltage-Gated Na Channels (Boards LB69 - LB73) L3130-Pos Board LB69 EVALUATING SMALL MOLECULE-ION CHANNEL INTERACTIONS USING ALL-ATOM MD SIMULATIONS. Randy K. Appiah , Vineeth Vanga, Spencer Lile, Haley Waltman, Carlie Willingham, Steven R. Gwaltney, Christopher N. Johnson L3131-Pos Board LB70 FUNCTIONAL EXPRESSION OF THE VOLTAGE-GATED SODIUM CHANNEL NA V1.5 IN MOUSE INTRINSIC CARDIAC NEURONS. Aurélien Chatelier L3132-Pos Board LB71 INTEGRATED IN VITRO STRATEGY FOR ACCELERATED DISCOVERY OF SO DIUM CHANNEL MODULATORS. Bin Bin Wei L3133-Pos Board LB72 PROBING THE DRUGGABILITY OF THE PROTEIN-PROTEIN INTERACTION INTERFACE IN IFGF13/NAV CHANNEL COMPLEXES USING AF MODELS AND STRUCTURE-BASED VIRTUAL SCREENING. Zahra Haghighijoo L3134-Pos Board LB73 AUTORESISTANCE STRATEGIES IN TOXIC BIRDS. Evelina Gromilina , Zhiying Jia, Fayal Abderemane-Ali Anion Channels (Boards LB74 - LB75) L3135-Pos Board LB74 CRYO-EM STRUCTURES OF BOVINE CLC-K IN COMPLEX WITH SMALL MOLECULE INHIBITORS TO BOLSTER DEVELOPMENT OF DRUGS AGAINST HYPONATREMIA. Natasa Trifkovic , Juergen Kreiter, Chih-Ta Chien, Andrew Hinman, Wah Chiu, Merritt Maduke L3136-Pos Board LB75 STRUCTURE AND CL - CONDUCTANCE PROPERTIES OF THE OPEN STATE OF HUMAN CFTR. Zhi Wei Zeng , Christopher E. Ing, Régis Pomès Skeletal Muscle Mechanics, Structure, and Regu lation (Boards LB76 - LB78) L3137-Pos Board LB76 INVESTIGATING THE EFFECT OF TITIN ISOFORMS ON RESIDUAL AND PAS SIVE FORCE ENHANCEMENT IN SINGLE MYOFIBRILS. Shuyue Liu , Venus Joumaa, Tim Leonard, Walter Herzog L3138-Pos Board LB77 STRUCTURE OF RABBIT PSOAS SKELETAL MUSCLE THICK FILAMENTS AT 9 A RESOLUTION BY CRYO-ELECTRON MICROSCOPY SINGLE PARTICLE ANALY SIS. Pouria Gholami Tilko , Hosna Rastegarpouyani, Kenneth Taylor L3139-Pos Board LB78 SELECTIVELY INHIBITING FAST-SKELETAL MYOSIN DOES NOT INHIBIT POST-TETANIC POTENTIATION IN MURINE SKELETAL MUSCLE. Breanne N. Stamper , Ying Qian, Mike DuVall, Jessica A. Tolley, Kat Chmykh, Weikang Ma, Molly Madden, Marc Evanchik, Ben Barthel, Carlos L. del Rio, Thomas C. Irving, Alan J. Russell Microtubules, Structure, Dynamics, and Associated Proteins (Boards LB79 - LB80) L3140-Pos Board LB79 NON-CANONICAL MICROTUBULE ARCHITECTURES IN PLASMODIUM ARE DEFINED BY STRUCTURAL PROPERTIES OF PARASITE TUBULIN. Mamata Bangera, Jiangbo Wu, Dominik Fachet, Gregory A. Voth, Simone Reber, Carolyn A. Moores

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