BPS2025 Full Program

Exhibitor Registration 8:00 am - 5:00 pm, West Lobby Drug Discovery for Ion Channels XXV Satellite Meeting 8:00 am - 5:15 pm, Room 501ABC Sponsored by AXXAM S.p.A.; Metrion Biosciences; Nanion Technologies; SB Drug Discovery; and Sophion Bioscience Ion channels are an important class of therapeutic drug targets, and mutations in ion channel genes are found to be responsible for an increasing number of diseases. While conventional electrophysiological techniques permit the most detailed and direct study of ion channel function, they are limited due to the manual nature of the method and their low throughput. Because of this, ion channels remain an underrep resented target class for drug discovery. The advent of higher throughput automated electrophysiology systems changed the face of ion channel drug discovery. Since the inaugural “Drug Discovery for Ion Channels” satellite meeting, there have been many advances in ion channel drug discovery including new instru mentation and techniques. For this year, we propose to continue the “Satellite Meeting” tradition at the Biophysical Society Annual Meeting and review the advances ion channel drug discovery. This year’s meeting will highlight presentations from drug discovery companies, companies that provide ion channel services to drug dis covery companies and companies that provide products to ion channel drug discovery companies, as well as other speakers in the field of ion channel drug discovery, including several academic speakers. 8:00 AM REGISTRATION AND COFFEE 8:30 AM WELCOME AND OPENING REMARKS Chris Mathes SESSION I Chair: Daniel Sauter 8:45 AM GABA B RECEPTOR MODULATION OF MEMBRANE EXCITABILITY IN HUMAN PLURIPOTENT STEM CELL-DERIVED SENSORY NEURONS BY BACLOFEN AND Α-CONOTOXIN VC1.1. Keynote Speaker: David Adams 9:30 AM DIMINAZENE REVEALS UNEXPECTED ASIC BIOLOGY. John Gilchrist 10:00 AM SUBTYPE-SELECTIVE MODULATION AND RESCUE OF HCN1 CHANNEL MUTANTS. Jun Chen 10:30 AM COFFEE BREAK SESSION II Chair: Jean-Francois Rolland 11:00 AM TARGETING ION CHANNELS WITH DE NOVO DESIGNED MINI PROTEINS. Stephan Pless 11:30 AM MINING THE VOLTAGE-GATED NA+ CHANNEL FOR NEUROTHERAPEU TICS DEVELOPMENT. Fernanda Laezza

12:00 PM ENGINEERING SELECTIVE INHIBITION OF NAV1.5 TO ASSESS THE COMPOSITION OF THE CARDIAC SODIUM CURRENT. Chris Ahern 12:30 PM LUNCH (PROVIDED) SESSION III Chair: Niels Fertig 1:30 PM TARGETING AMPA RECEPTORS IN COMPLEX WITH TARP-G8 FOR EPILEPSY AND PAIN. Jose Matta 2:00 PM TARGETING POTASSIUM CHANNELS IN BRAIN TUMOR-INITIATING CELLS. A SMALL MOLECULE INHIBITOR OF APOL1 ATTENUATES ALBUMINURIA IN A MOUSE MODEL OF APOL1 KIDNEY DISEASE. Victoria Assimon 3:00 PM COFFEE BREAK SESSION IV Chair: Stephen Jenkinson 3:30 PM DYNAMIC ACTION POTENTIAL CLAMP FOR THE FUNCTIONAL CLASSIFI CATION OF SCN2A VARIANTS. Kris Kahlig 4:00 PM SCRAMBLING MOSQUITO OLFACTION TO DETER THE BUZZING MENACE. Jose Mercado 4:30 PM CARDIOTOXIC EFFECTS OF PSYCHOACTIVE SYNTHETIC CANNABINOID RECEPTOR AGONISTS. Nina Ottossen 5:00 PM CLOSING REMARKS Niels Fertig Fifty-Five Molar Stuff in Molecular Interactions Honoring Adrian Parsegian’s Work Satellite Meeting 9:00 am - 6:00 pm, Room 511ABC S ponsored by NIH This Satellite Meeting at the BPS 2025 is being organized in memory of our friend, teacher, and colleague, Professor Adrian Parsegian, who passed away on July 5th, 2023. He was an outstanding scientist, an outstanding mentor, and an outstanding human being. Soon after earn ing his PhD in Biophysics from Harvard University, he joined NIH, where he spent 42 years. During this tenure, professor Parsegian became a leader in membrane biophysics, with his name known and respected by every biophysicist in the world. From 1983 to 1984, Professor Parsegian served as the President of the Biophysical Society. For many years, he was the Editor-in-Chief of the Biophysical Journal and the Founding Editor of the Biophysical Discussions. He worked for most of these years in the NICHD, NIH, consequently establishing the institute as a capital of membrane and cellular biophysics. In 2009, he accepted the Gluckstern Professor of Physics position at UMass, Amherst. SESSION I Chair: Sergey Bezrukov 9:00 AM ADRIAN, THE BRAIN THAT SPARKED A THOUSAND FIELDS. Joshua Zimmerberg 9:20 AM Xi Huang 2:30 PM

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