BPS2025 Full Program

12-Subg 3:00 pm MECHANOTRANSDUCTION AT THE NUCLEAR PORE COMPLEX: INSIGHTS FROM A NOVEL GP210 FORCE SENSOR. Peipei Wang , GW Gant Luxton, Daniel Conway 3:10 pm break 3:20 pm business meeting 13-Subg 3:30 pm ENGINEERING A TUMOR-SENSITIVE PRODRUG T CELL ENGAGER BISPE CIFIC ANTIBODY FOR SAFER IMMUNOTHERAPY. Amelia McCue , Ste phen Demarest, Karen Froning, Michael Hickey, Stephen Antonysamy, Brian Kuhlman 14-Subg 3:40 pm MTORC1 AND ERK CONVERGE TO INITIATE TRANSLATION FOLLOWING HYPERTROPHIC STIMULATION OF CARDIOMYOCYTES. Keita Uchida , Benjamin L. Prosser No Abstract 3:50 pm BIOPHYSICS OF CANCER AND IMMUNE CELL MIGRATION IN BRAIN TIS SUE. David Odde No Abstract 4:15 pm PHENOTYPIC INSIGHTS INTO RIGHT VENTRICULAR BIOMECHANICS IN PATIENTS WITH PULMONARY HYPERTENSION. Rebecca Vanderpool No Abstract 4:40 pm MECHANICAL CUES MEDIATE P-CADHERIN DEPENDENT ADHESIONS REQUIRED FOR EPITHELIAL MORPHOGENESIS. Priscilla Hwang No Abstract 5:05 pm THE IMPACT OF RIGIDITY AT THE NANOPARTICLE: IMMUNE CELL INTER FACE. Elizabeth Wayne 5:29 pm closing remarks Intrinsically Disordered Proteins Symposium 1:30 pm - 5:30 pm, Petree Hall C Subgroup Chair Samrat Mukhopadhyay, Indian Institute of Science Education and Re search (IISER) Mohali, India Program Co-Chairs Dorothee Dormann, Johannes Gutenberg University, Mainz, Germany Lukasz Joachimiak, University of Texas Southwestern Medical Center, USA 1:30 pm opening remarks No Abstract 1:35 pm LEVERAGING HIGH-THROUGHPUT AND QUANTITATIVE MICROFLUIDIC ASSAYS TO UNDERSTAND HOW IDP SEQUENCE ENCODES FUNCTION. 2:00 pm DEEP MUTAGENESIS TO EXTRACT MECHANISTIC INSIGHTS INTO AMY LOID TRANSITION STATES. Benedetta Bolognesi 2:20 pm student/postdoc talk 2:35 pm student/postdoc talk 2:50 pm break No Abstract 3:00 pm CHANGES IN GLOBAL RNA-PROTEIN METABOLISM DURING AGEING CAUSE ALTERATION IN RNA-RBP PROPERTIES. Shovamayee Maharana Polly Fordyce No Abstract

15-Subg 3:20 pm BIOPHYSICAL CONSERVATION OF INTRINSICALLY DISORDERED REGIONS. Alex S. Holehouse 3:40 pm student/postdoc talk 16-Subg 3:55 pm ROLE OF PUTATIVELY HELICAL REGIONS IN DISORDERED SEGMENTS OF UBIQUITIN-BINDING SHUTTLE PROTEINS. Carlos A. Castaneda 17-Subg 4:15 pm HOW DOES AN IDP ASSEMBLE INTO AMYLOID? Sheena E. Radford 5:00 pm closing remarks 5:05 pm business meeting Macromolecular Machines and Assemblies Symposium 1:30 pm - 5:30 pm, Petree Hall D Subgroup Chair Tatiana Mishanina, University of California, San Diego, USA 1:30 pm opening remarks No Abstract 1:35 pm REGULATION OF ATP-DEPENDENT PROTEOLYSIS BY MEMBRANE-AN CHORED ASSEMBLIES. Alireza Ghanbarpour No Abstract 2:00 pm STRUCTURAL BIOLOGY OF TELOMERASE MECHANISM, INTERACTIONS, AND ASSEMBLY. Juli Feigon 2:25 pm student/postdoc talk No Abstract 2:50 pm STRUCTURAL BASIS OF A TRANSCRIPTION-REGULATING RNA ELEMENT, HK022 PUT. Jin Young Kang 3:15 pm break No Abstract 3:30 pm TUG OF WAR: A MECHANISTIC BASIS FOR R-LOOP FORMATION BY TRANSCRIBING RNA POLYMERASE. Terence Strick 3:55 pm student/postdoc talk No Abstract 4:20 pm MOLECULAR AND BROWNIAN DYNAMICS SIMULATIONS OF ROTATORY CATALYSIS IN MOLECULAR MOTORS. Abhishek Singharoy No Abstract 4:45 pm GENETIC ARCHITECTS: HOW THE LINE-1 RETROTRANSPOSON CRAFTS THE HUMAN GENOME. Akanksha Thawani 5:10 pm business meeting 5:25 pm closing remarks

S A T U R D A Y

Mechanobiology Symposium 1:30 pm - 5:30 pm, Room 501ABC

Subgroup Chair Amit Pathak, Washington University, USA 1:30 pm opening remarks No Abstract 1:35 pm INTEGRIN MODULATION OF CELLULAR MECHANORESPONSES. Johanna Ivaska

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