BPS2025 Full Program

Symposium Mechanobiology: The Role of Forces in Development 10:45 am - 12:45 pm, Petree Hall D Chair Julie Theriot, University of Washington, USA 867-Symp 10:45 am COLLECTIVE CELL MOVEMENTS: CELLULAR AND MOLECULAR DYNAM ICS AT THE LEADING EDGE. Ana Maria do Carmo, Ji H. Sayo, Rodrigo Fernandez-Gonzalez 868-Symp 11:10 am INSIGHTS GAINED FROM SPATIAL MODELS OF CELLULAR MECHANO TRANSDUCTION. Padmini Rangamani 869-Symp 11:35 am CELL-CELL INTERACTIONS ARE MODULATED BY FORCE SENSING ION CHANNELS. Samantha Webster, Lioba Schroeter, Phoebe Dunbabin, Abie Cargando, Kate Poole 870-SympSelect 12:00 pm PHYSICAL FORCES AND PATTERNS OF DIFFERENTIATION IN THE DEVEL OPING LUNG. Samhita Banavar , Jake J. Klimek, Eric W. Fowler, Anna B. Liu, Celeste M. Nelson 871-Symp 12:20 pm NEUTROPHIL SHAPE CHANGES GENERATE DYNAMIC CYCLES FOR 3D MIGRATION. Aaron P. van Loon, Julie A. Theriot Symposium Optogenetics: From Signaling to Cell Behavior 10:45 am - 12:45 pm, Room 515A Chair Keiichi Inoue, The University of Tokyo, Japan 872-Symp 10:45 am SHEDDING LIGHT ON MECHANISMS OF SEIZURE ONSET: OPTOGENETIC CIRCUIT MANIPULATION IN MOUSE MODELS OF EPILEPSY. Joanna Mattis 873-Symp 11:35 am FREE ENERGY ANALYSIS OF SELECTIVE CATION TRANSPORT IN THE CHANNELRHODOPSIN CHIMERA, C1C2. Susan Rempe , Lindsey A. Pri gnano, Mark J. Stevens, Juan M. Vanegas, Robert E. Dempski 874-SympSelect 12:00 pm DEFINING INTRACELLULAR AND INTERCELLULAR COMMUNICATION DURING INFLAMMATORY LYTIC CELL DEATH. Teak-Jung Oh, Zixiao Li, Amna Mehfooz, Bryan Gworek, Vishnu Krishnamurthy, Kai Zhang 875-Symp 12:20 pm UNIQUE CHARACTERISTICS OF NOVEL CAROTENOID-BINDING RHODOP SINS. Keiichi Inoue Platform Protein Dynamics and Allostery I 10:45 am - 12:45 pm, Room 515B Co-Chairs Rosalie Lawrence, University of California, San Francisco, USA Steffen Wolf, University of Freiburg, Germany 876-Plat 10:45 am UNEXPECTED MICHAELIS-MENTEN BEHAVIOR OF COMPLEX MARKOV MODELS. Malte Schäffner , Helmut Grubmuller

877-Plat 11:00 am SINGLE-MOLECULE SENSING WITHIN STEREO AND REGIO CONTROL LABLE HETERO-NANOPORES. Chao-Nan Yang , Wei Liu, Ji-Chang Zhang, Yi-Lun Ying, Yi-Tao Long 878-Plat 11:15 am A HELICAL FULCRUM IN EIF2B COORDINATES ALLOSTERIC REGULATION OF STRESS SIGNALING. Rosalie Lawrence , Sophie Shoemaker, Aniliese Deal, Lan Wang, Susan Marqusee, Peter Walter 879-Plat 11:30 am UNDERSTANDING STRUCTURAL DYNAMICS OF ALLOSTERY ACROSS TIME- AND LENGTH SCALES. Steffen Wolf , Veronika Frank, Christian Beck, Benedikt Sohmen, Tilo Seydel, Ingo Hoffmann, Bianca Hermann, Mark F. Nueesch, Marco Grimaldo, Gerhard Stock, Frank Schreiber, Felix Roosen-Runge, Thorsten Hugel 880-Plat 11:45 am Travel Award Winner DYNAMICS OF PHOTOSYSTEM II: THE ALLOSTERIC-LIKE REGULATION OF REDOX MECHANISMS BY WATER. Jinchan Liu , Ke R. Yang, Gary W. Brudvig, Victor S. Batista 881-Plat 12:00 pm HOW SINGLE SITE BIASES AND PAIRWISE COUPLING IN PROTEIN SE QUENCES AFFECT COOPERATIVITY AND ALLOSTERY. Soumya P. Behera , Ananya K. Majumdar, Doug Barrick 882-Plat 12:15 pm USING DYNAMICAL-NONEQUILIBRIUM MD SIMULATIONS TO UNDER STAND DRUG RESISTANCE AND ALLOSTERY IN PROTEINS. Sofia Oliveira , Adrian J. Mulholland 883-FlashTalk 12:30 pm Canceled DISEASE ASSOCIATED POINT MUTATIONS PROBE THE BIOPHYSICS OF CALMODULIN CALCIUM HANDLING AND CONFORMATIONAL CHANGE. Justin R. Lovett , Sara A. Garcia, Emily M. Campbell, Christopher N. Johnson 884-FlashTalk 12:35 pm Travel Award Winner CHARACTERIZATION OF BAT CORONAVIRUS SPIKE GLYCOPROTEIN DY NAMICS VIA MOLECULAR DYNAMICS SIMULATIONS. Toheeb A. Balogun , Cory M. Acreman, Fiona L. Kearns, Alexandra L. Tse, Gorka Lasso, Emily H. Miller, Kartik Chandran, Jason S. McLellan, Rommie E. Amaro 885-FlashTalk 12:40 pm DEVELOPMENT AND STRUCTURAL ELUCIDATION OF A FLUORESCENT ANTIBODY SENSOR DEPENDENT ON ALLOSTERIC CHANGES. Erik P. Stahl Platform

M O N D A Y

Membrane Active Peptides 10:45 am - 12:45 pm, Room 502A

Co-Chairs Amy Rice, NIH, USA Jin Yan, Yale University, USA 886-Plat 10:45 am

ANTIMICROBIAL PEPTIDE BEHAVIOUR IN THE E.COLI CELL ENVELOPE: THE COMPLEXITY MATTERS. Cyril Schroeder , Dhanushka Weerakoon, Syma Khalid 887-Plat 11:00 am DE NOVO DESIGN OF LIPID SCRAMBLING PROTEINS. Niek van Hilten , Michael Grabe 888-Plat 11:15 am SINGLE AMINO ACID DRIVES LL-37 AND HNP1 SYNERGY: UNVEILING ANTIMICROBIAL PEPTIDE INTERACTIONS. Ariane M. Schwitter , Kaori Sugihara

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