BPS2026 Program Book

Platform Protein-Nucleic Acid Interaction I 4:00 pm - 6:00 pm, Room 204/205/206

Platform Single-Molecule Spectroscopy 4:00 pm - 6:00 pm, Room 207/208

M O N D A Y

Co-Chairs Hannah Boyer, University of Washington, USA Xingcheng Lin, North Carolina State University, USA 786-Plat 4:00 pm

Co-Chairs Apurba Paul, University of Notre Dame, USA Thorsten Wohland.National University of Singapore 796-Plat 4:00 pm

MECHANISM OF SARS-COV-2 RESISTANCE TO NUCLEOTIDE ANALOG BASED ANTIVIRALS. Yang Yang, Xiaocong Cao, Yu Li, Ryan Gleason, Gloria Luo, Scott Becker, Bin Liu, Chang Liu 787-Plat 4:15 pm SINGLE-MOLECULE TRACKING SHOWS ORCHESTRATION OF THE DNA MISMATCH REPAIR PATHWAY IN LIVE BACTERIA. Amy N. Moores , Nehir Banaz, Tendai Makamure, Stephan Uphoff 788-Plat 4:30 pm CHAPERONE FUNCTIONS OF H1 LINKER HISTONE DRIVING CANONICAL AND CENTROMERIC CHROMATIN ASSEMBLY. Ahmed Yesvi Rafa , Shaun Filliaux, Yuri L. Lyubchenko 789-Plat 4:45 pm INTEGRATING SPARSE SEQUENCE, EXPERIMENTAL, AND AI-PREDICTED STRUCTURES FOR PROTEIN-NUCLEIC ACID INTERACTION PREDICTIONS. Yafan Zhang, Eduardo Cisneros, Irene Silvernail, Rina Li, Thomas Thorn ton, Xingcheng Lin 790-Plat 5:00 pm THE HUMAN RMI1-2 COMPLEX FACILITATES TOPOISOMERASE IIIA GATE CLOSURE AND ALLEVIATES HIGH-TENSION INHIBITION OF DNA DECAT ENATION. Gabor Harami , Hajnalka Harami-Papp, Ian L. Morgan, Xi Yang, János Pálinkás, Mihaly Kovacs, Keir C. Neuman 791-Plat 5:15 pm USING NANOPORE TWEEZERS TO OBSERVE SARS-COV-2 HELICASE INHI BITION AT SINGLE-NUCLEOTIDE RESOLUTION. Hannah J. Boyer , Evelyn Olivares Fernandez, Ethan Poladian, Jared R. Ramsey, Jonathan M. Craig, Sarah Abell, Francisco Alvarado-Medina, Eric Lebo, Michaela Franzi, Tarun M. Kapoor, Andrew H. Laszlo, Jens H. Gundlach 792-Plat 5:30 pm Travel Award Winner WIELDING DNA LOOPING AND SUPERCOILING TO UNDERSTAND NU CLEOSOME STRUCTURE AND DYNAMICS. Silvia L. Summers , Matthew L. Baker, E. Lynn Zechiedrich 793-FlashTalk 5:45 pm PHYSICS-CONSTRAINT DEEP LEARNING TO UNDERSTAND AND DESIGN BASE EDITORS. Giulia Palermo , Mohd Ahsan, Chinmai Pindi, Amun C. Patel, Audrone Lapinaite 794-FlashTalk 5:50 pm COARSE-GRAINED MODELING OF PROTEIN-DNA INTERACTIONS: REPRO DUCING EXPERIMENTAL BINDING AFFINITY. Melika Shekari , Christo pher Maffeo, Aleksei Aksimentiev 795-FlashTalk 5:55 pm Travel Award Winner INTERPLAY BETWEEN THE HEPC VIRUS RNA MOTIF 5BSL3.2, RDRP NS5B AND HNRNP A1. Eesha Gupte , Alisha Jones

EFFICIENT IMAGING FLUORESCENCE FLUCTUATION SPECTROSCOPY ANALYSIS THROUGH VISION TRANSFORMERS. Thorsten Wohland , Shao Ren Sim, Zijie Wang, Shiyue Zhou 797-Plat 4:15 pm TRANSCRIPTIONAL ACTIVATION AND RNA REGULATORY KINETICS IN LIV ING CELLS STUDIED BY 3D ORBITAL TRACKING FLUORESCENCE CROSS CORRELATION SPECTROSCOPY. Chythra Jayaram Nisha , Jessica Roberts, Eric Hayden, Matthew L. Ferguson 798-Plat 4:30 pm SEPARATION ESTIMATION OF TWO FREELY ROTATING DIPOLE EMITTERS NEAR THE QUANTUM LIMIT . Sheng Liu , Sujeet Pani, Sajjad A. Khan, Francisco E. Becerra, Keith A. Lidke 799-Plat 4:45 pm Travel Award Winner MOLECULAR-SCALE DISSECTION OF BACTERIAL PROTEIN INTERACTIONS WITH 3D EXPANSION-PALM. Chiara Caldini , Sara Del Duca, Alberto Vas sallo, Giulia Semenzato, Renato Fani, Francesco Saverio Pavone, Lucia Gardini 800-Plat 5:00 pm SINGLE MOLECULE INVESTIGATION OF BOTULINUM NEUROTOXIN TRANSLOCATION. Changcheng Zhang, Fiona McEvoy, Frank Mindlin, Mark E. Bowen 801-Plat 5:15 pm PEPTIDE SEQUENCING WITH SINGLE ACID RESOLUTION USING A SUB NANOMETER DIAMETER PORE. Apurba Paul , Archith Rayabharam, Lisa Almonte, Eveline Rigo, Joshy Joseph, Ashutosh Kumar, Zhuxin Dong, Narayana Aluru, Gregory L. Timp 802-Plat 5:30 pm VISUALIZING AND QUANTIFYING PROTEIN FRICTION IN NATIVE MEM BRANES. Mingdong Dong 803-FlashTalk 5:45 pm Travel Award Winner UNRAVELING EGFR SPONTANEOUS RUPTURE AND COMPRESSIBILITY CHANGES UNDER AN EXTERNAL PICONEWTON COMPRESSIVE FORCE. Dedunu S. Senarathne , Lalita Shahu, H. Peter Lu 804-FlashTalk 5:50 pm SMLM AND IMAGE CONTRAST ENHANCEMENT WITH BODIPY DYE CON JUGATES. Yu Xu , Gillian Cartwright, David Garenne, Vincent Noireaux, Elias Puchner 805-FlashTalk 5:55 pm PROBING BIOPOLYMERS’ CONFORMATIONAL SPACE USING PIPETTE ELASTOMER INTERFACIAL NANOPORES. Justin N. Cronk , Alessio A. Bufalini, Morteza Aramesh

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