BPS2026 Program Book

879-Pos Board B53 SELECTIVE MRNA DECODING BY METHYLATED EEF1A SHAPES NEOPLAS TIC PROTEOMES. Francisco Aaron Cruz Navarrete , Shuo Liu, Simone Hausmann, Krzysztof Szkop, Julia Vu, Ryan Brady, Rui Dong, Xiaoyin Lu, Natasha Flores, Sabeen Ikram, Emily Zahn, Julia Thompson, Benjamin Garcia, Ola Larsson, Ivan Topisirovic, Scott C. Blanchard, Or Gozani, Pawel Mazur 880-Pos Board B54 ACTIVATION HEAT CAPACITY AND DYNAMICAL NETWORKS IN THERMO ADAPTATION: TRIOSEPHOSPHATE ISOMERASE. Dan Pike , Swati Singh, Erica Prentice, Sofia Oliveira, Vickery L. Arcus, Adrian J. Mulholland 881-Pos Board B55 A REDUCED-PARTICLE REPRESENTATION FOR CAPTURING LARGE-SCALE DOMAIN MOTIONS. Chigusa Kobayashi , Yuji Sugita 882-Pos Board B56 UNRAVELING THE IMPACT OF W215A/E217A MUTATIONS ON THROM BIN’S DYNAMICS AND THROMBOMODULIN BINDING THROUGH MO LECULAR DYNAMICS SIMULATIONS. Freddie R. Salsbury , Dizhou Wu 883-Pos Board B57 FUNCTIONAL CONSEQUENCES TO OLIGOMERIC STATE CHANGES IN HU MAN GLUTAMINE SYNTHETASE. Markus C.B. Tecson , Hiroki Yamamura, Cyrina Joy Geluz, Katherine Martinez, Samuel Hoff, Dan R. Fournier, Madison Hales, Ryan Leung, Emily Hernandez, Yuly Cruz, Massimiliano Bonomi, Emma C. Carroll, Eric R. Greene 884-Pos Board B58 ALLOSTERIC INHIBITION MECHANISM OF PTP1B USING MOLECULAR DYNAMICS SIMULATION. Koki Yano , Ikki Yasuda, Yoshinori Hirano, Kenji Board B59 INVESTIGATING THE DYNAMIC RESPONSE OF THE MOTOR PROTEIN SECA DURING PROTEIN TRANSLOCATION. Dulcie Havers , William Allen, Joel A. Crossley, Sofia Oliveira, Ian Collinson 886-Pos Board B60 LOADING-DIRECTION DEPENDENT RESPONSES OF ALPHA BETA T-CELL RECEPTORS. Wonmuk Hwang , Aoi Akitsu, Kristine N. Brazin, Jonathan S. Duke-Cohan, Evan H. Kirkpatrick, Robert J. Mallis, Andrew Parkins, Han nah Stephens, Kemin Tan, Matthew J. Lang, Ellis L. Reinherz 887-Pos Board B61 MOLECULAR DYNAMICS INSIGHTS INTO MPER-TM AND LIPID INTERAC TIONS OF HIV-1 BROADLY NEUTRALIZING ANTIBODIES. Yue Qiu , Kemin Tan, Young Do Kwon, Thomas Walz, Ellis L. Reinherz, Mikyung Kim, Wonmuk Hwang 888-Pos Board B62 A NEWLY DISCOVERED CRYPTIC POCKET IN EBOLA VP35 CONTROLS PROTEIN-PROTEIN INTERACTIONS. Devin G. Kelly , Shahlo O. Solieva, Mark B. Bray, Prajna Mishra, Gregory R. Bowman 889-Pos Board B63 Travel Award Winner EFFECTS OF KEY MUTAGENESIS ON STUDYING THE BINDING INTERAC TIONS BETWEEN VCCI AND XCL1. Oluebube C. Onwuzulu 890-Pos Board B64 MOLECULAR DYNAMICS SIMULATIONS UNDER LOAD OF THREE DIS TINCT T-CELL RECEPTORS RECOGNIZING THE SAME TRUNCAL TUMOR TP53 NEOANTIGEN REVEAL DIFFERENTIAL STABILITY OF THEIR TCR PHLA COMPLEXES. Mahoora N. Naghinejad , Robert J. Mallis, Matthew J. Lang, Ellis L. Reinherz, Wonmuk Hwang Yasuoka 885-Pos

891-Pos Board B65 INVESTIGATING THE HETEROGENEITY OF PROTEIN KINASE A SIGNALING USING SUPER-RESOLUTION MICROSCOPY. Brandon M. Liu , Safal Shres tha, Connor Cronin, Coco M. Li, Jin Zhang, Susan S. Taylor, Christopher J. Obara 892-Pos Board B66 COMPARING DIFFERENT ENSEMBLES OF PROTEIN STRUCTURES TO GENERATE DYNAMICS. Weixia Deng , Robert L. Jernigan 893-Pos Board B67 DIRECTIONAL COUPLING AND ASYMMETRY EXPLAIN LIGAND SPECIFIC ALLOSTERIC REGULATION IN LACI. Christopher Ausbeck , Paul Campitelli, David Ross, Liskin Swint-Kruse, S. Banu Ozkan 894-Pos Board B68 DECOUPLING SHP2 ALLOSTERIC ACTIVATION FROM BINDING TO ITS PHOSPHORYLATED PARTNERS. Alessandro Strofaldi , Chiara Innamorati, Daniela Roversi, Claudia Storti, Luca Pannone, Simone Martinelli, Paolo Calligari, Barbara Biondi, Cristina Peggion, Fernando Formaggio, Gianfranco Bocchinfuso, Lorenzo Stella 895-Pos Board B69 PROBING THE EFFECT OF PORE LOOP MUTATIONS ON THE GATEWAY TRANSITIONS OF CASEINOLYTIC PEPTIDASE P USING MACHINE LEARN ING AND MOLECULAR DYNAMICS. Hayden Dennison , Ashan Dayanan da, Tharushi Rajaguru, George Stan 896-Pos Board B70 REVEALING THE CONFORMATIONAL DYNAMICS OF HSP104 USING MARKOV STATE MODELLING AND MACHINE LEARNING. Sumedhi Jayasekara , Tharushi Rajaguru, Ashan Dayananda, George Stan 897-Pos Board B71 TOPOLOGICAL METRICS PREDICT PROTEIN CONFORMATIONAL DYNAM ICS AND EVOLUTIONARY TRAJECTORIES. Nikhil Ramesh , S. Banu Ozkan, Eleni Panagiotou 898-Pos Board B72 PREDICTING PROTEIN DYNAMICS USING LARGE LANGUAGE MOD ELS. Zahra Alavi 899-Pos Board B73 Travel Award Winner ACTIVATION-INDUCED LYSOSOMAL TETHERING ENHANCES TNFΑ VESICLE TRAFFICKING IN JURKAT T CELLS. Alyssa Burgess , Hirushi T. Gunasekara Kalu Arachchige, Han Xu, James Xie, Ying S. Hu 900-Pos Board B74 A TARGETABLE CRYPTIC POCKET IN EBOLA VP35 PERSISTS UNDER PHYSI OLOGICAL CROWDING MIMICS. Prajna Mishra , Gregory Bowman Membrane Protein Structure I (Boards B75 - B98) 901-Pos Board B75 STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF THE HUMAN MAGNESIUM CHANNEL MRS2. Nicholas D. Clark , Isadora Rocha De Abreu, Madolyn Britt, Louis Tung Faat Lai, Peter R. Johnson, Alexander J. Sodt, Doreen Matthies 902-Pos Board B76 THE INVESTIGATION OF GDP/GTP EXCHANGE IN ACTIVATED DOPAMINE RECEPTOR D1 IN COMPLEX WITH GS PROTEIN THROUGH IN SILICO SUBMOLECULAR ANALYSIS. XingYan Lai , Hao-Jen Hsu 903-Pos Board B77 Travel Award Winner UNRAVELLING RAPID KINETICS DRIVING HUMAN DAYLIGHT VISION. Sarah Luise Schmidt , Miroslav Kloz, Polina Isaikina

M O N D A Y

79