BPS2026 Program Book

1063-Pos Board B237 UNRAVELING CLATHRIN’S ROLE IN DRIVING MEMBRANE FISSION DURING ENDOCYTOSIS. Nicoletta Bouzos , Samuel Foley, Margaret E. Johnson, Wade F. Zeno 1064-Pos Board B238 ION FLUX CAUSES THE RELEASE OF EXTRACELLULAR VESICLES FROM NEURONAL CELLS. Greta E. Schmidt , Suzanne F. Scarlata 1065-Pos Board B239 CORTICAL ADHESION-DIRECTED MEMBRANE FLOW ACTIVATES ULTRA FAST ENDOCYTOSIS IN NEURONS. Yingwen Huang, Ioana C. Butu, Ben O’Shaughnessy 1066-Pos Board B240 REGRESSION-GUIDED COMPUTATIONAL PIPELINE TO IDENTIFY SEX SPECIFIC THERAPEUTIC STRATEGIES FOR ATRIAL FIBRILLATION. Nathaniel T. Herrera , Charlotte Smith, Yixuan Wu, Haibo Ni, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi 1067-Pos Board B241 COMPUTATIONAL MODELING OF PEDIATRIC ATRIAL ELECTROPHYSIOLO GY: AGE-DEPENDENT BIOMARKERS AND THE ROLE OF PATIENT-SPECIFIC HEART RATES. Gabriella M. Ellks , Devon Guerrelli, Shatha Salameh, Nikki G. Posnack, Seth H. Weinberg 1068-Pos Board B242 IN SILICO ANALYSIS OF ATRIAL REMODELING AND ARRHYTHMIA SUS CEPTIBILITY IN TYPE 2 DIABETES MELLITUS. Isabella Doherty , Yixuan Wu, Haibo Ni, Kenneth Tran, Eleonora Grandi 1069-Pos Board B243 SINOATRIAL NODE NETWORK STRUCTURE EMERGES FROM ADAPTIVE GAP JUNCTION PLASTICITY. Nicolae Moise , Seth H. Weinberg 1070-Pos Board B244 INTERCALATED DISC NANOSTRUCTURE REGULATES LOCAL IONIC CUR RENTS AND CARDIAC CONDUCTION. Ruichen Sui , Nicolae Moise, Seth H. Weinberg 1071-Pos Board B245 BROKEN CLOCKS AND INTRANODAL CONDUCTION SHIFTS UNDERLIE SINOATRIAL NODE DYSFUNCTION IN CARDIOMYOCYTE-SPECIFIC ZO-1 KNOCKOUT MICE. Rui Zhang , Dexin Chen, Peixin He, Seho Kim, Liang Li, Sarah Teboull, Daniel Adolfo, Ashmeen Mahal, Robert S. Ross, Joshua I. Board B246 SIMULATING THE IMPACT OF MICROGRAVITY ON CARDIAC ALTER NANS AND AFTERDEPOLARIZATIONS. Tymoteusz F. Bak , Daisuke Sato, Eleonora Grandi 1073-Pos Board B247 ELECTROPHYSIOLOGICAL EFFECTS OF TESTOSTERONE IN A RABBIT MODEL OF HEART FAILURE WITH PRESERVED EJECTION FRACTION. Xiao Liu , Po-Tseng Lee, Minjing Yang, Liyang Zhang, James E. Tisdale, Peng Sheng Chen 1074-Pos Board B248 SARCOPLASMIC RETICULUM PROVIDES MEMORY IN CARDIAC PACE MAKER CELLS. Akihiro Okamura , Isabella K. He, Michael P. Wang, Michael D. Stern, Edward G. Lakatta, Victor A. Maltsev Goldhaber 1072-Pos Cardiac, Smooth and Skeletal Muscle Electro physiol ogy (Boards B240 - B266)

1075-Pos Travel Award Winner A 3D HUMAN NEURO-CARDIAC ORGANOID MODEL REVEALS SYMPA THETIC DYSREGULATION IN MYOTONIC DYSTROPHY TYPE 1. Cyrielle Jajkiewicz , Mohamed Chahine 1076-Pos Board B250 REGULATION OF L-TYPE CALCIUM CHANNELS AND CALCIUM CYCLING BY LRRC10 IN HIPSC-CARDIOMYOCYTES. Natthaphat Siri-Angkul , Vladislav Leonov, Hee Jae Jang, Timothy J. Kamp 1077-Pos Board B251 PREDICTING LONG QT TYPE 3 ARRHYTHMIA RISK FOR VARIABLE EXTRACELLULAR IONIC CONCENTRATIONS. Katherine Flannery , Steven Poelzing, Seth H. Weinberg 1078-Pos Board B252 HUMANS AND SNAKES MAY COMPENSATE FOR “LOSS-OF-FUNCTION” MUTATIONS IN SKELETAL MUSCLE VOLTAGE-GATED SODIUM ION CHANNELS (NA V 1.4) USING THE SAME MECHANISM. Shana L. Geffeney , Rebekah Ward, Addison Woodford, Jon R. Thomas 1079-Pos Board B253 DIFFERENTIAL ROLES OF CX43 GAP JUNCTION CHANNELS AND HEMI CHANNELS IN CARDIAC DYSFUNCTION. Jonathan J. Quan , Manuel F. Munoz Camus, Priscila A. Araujo, Rida Khan, Adrian Sheehy, Pablo S. Gaete, Jorge E. Contreras 1080-Pos Board B254 RATIOMETRIC VOLTAGE-SENSITIVE DYES FOR OPTICAL ELECTROPHYSIOL OGY IN 3D HIPSC CARDIOMYOCYTE CULTURES. Dunia Garcia Cruz, Ping Yan, Joseph Adewuyi, Corey Acker, Leslie M. Loew 1081-Pos Board B255 LINKING TISSUE-LEVEL BETA-ADRENERGIC SIGNALING HETEROGENE ITY TO REPOLARIZATION ALTERNANS AND ARRHYTHMIA RISK. Roshni Shetty , Jessica L. Caldwell, Vladimir Sobota, Crystal M. Ripplinger, Daisuke Sato, Jason D. Bayer, Eleonora Grandi 1082-Pos Board B256 ENERGY COST SCALES SUPRALINEARLY WITH MUSCLE FORCE, AND THE EMERGENCE OF THIS NONLINEARITY FROM FIBER RECRUITMENT. Daniel J. Petersen , Sriram Muralidhar, Manoj Srinivasan, Sam Walcott 1083-Pos Board B257 IN SILICO CONFORMATIONAL DYNAMICS OF THE Α-ACTININ-2 ACTIN BINDING DOMAIN UPON PHOSPHORYLATION. Christopher Solís , Helene Tigro, Matthew C. Childers, Michael Regnier 1084-Pos Board B258 INTEGRATING SIGNALING AND MECHANICS TO PREDICT EXERCISE INDUCED MUSCLE HYPERTROPHY. Ingvild S. Devold , Marie E. Rognes, Padmini Rangamani 1085-Pos Board B259 CONDUCTION IN SCN1B+/- MOUSE HEARTS IS MORE SENSITIVE TO OSMOTIC CHANGES TO INTERCALATED DISC STRUCTURE. Rowan O. Maisonneuve , Chandra Bain, Clare Dennison, Gregory S. Hoeker, Steven Poelzing 1086-Pos Board B260 AMPLIFICATION OF STOCHASTIC RESONANCE IN CARDIAC PACEMAKER CELLS VIA COUPLING OF INTRACELLULAR CALCIUM SIGNALS TO MEM BRANE VOLTAGE. Isabella K. He , Akihiro Okamura, Alexander V. Maltsev, Anna Maltsev, Michael D. Stern, Edward G. Lakatta, Victor A. Maltsev 1087-Pos Board B261 MODELING THE RESPONSE OF A CARDIAC CELL PAIR TO AN EXTERNAL ELECTRIC FIELD GENERATES TESTABLE PREDICTIONS TO EVIDENCE EPHAPTIC COUPLING WITH OPTICAL MAPPING EXPERIMENTS. Marina Vannucci , Ena Ivanovic, Jan P. Kucera Board B249

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