BPS2026 Program Book

1137-Pos Board B311 MODULATING PROTEIN NETWORKS: INSIGHTS INTO KINASE-ION CHANNEL INTERACTIONS AND NEUROLOGICAL IMPLICATIONS FROM CHEMOINFORMATICS-GUIDED BIOPHYSICAL AND FUNCTIONAL STUD IES. Akanksha Gurtu , Hamid Teimouri, Aditya K. Singh, Mingxiang Zhou, Jia Zhou, Fernanda Laezza 1138-Pos Board B312 DEVELOPMENT OF SELECTIVE CLAUDIN CHANNEL BLOCKERS FOR CLAU DIN-15 AND CLAUDIN-2. Samaneh Sajjadi , Ye Li, Sukanya Konar, Jingjing Ma, Shaun Wood, Noora Matari, Le Shen, Christopher Weber, Fatemeh Khalili-Araghi 1139-Pos Board B313 MECHANISM OF UREA ACTIVATORS OF GIRK1/GIRK2 VERSUS GIRK1/ GIRK4 CHANNELS. Ana Santa Cruz 1140-Pos Board B314 CRYO-EM STUDY OF THE MALIGNANT HYPERTHERMIA-CAUSING T4826I MUTANT OF RYANODINE RECEPTOR 1 AND ITS REGULATION BY PHAR MACOLOGICAL INHIBITORS. Yu S. Chen , Maricela García-Castañeda, Rick Hu, Paul D. Allen, Filip Van Petegem 1141-Pos Board B315 STRUCTURAL BASIS OF VASCULAR-SPECIFIC KATP CHANNEL INHIBITION BY VU0542270. Sun Joo Lee , Camden M. Driggers, Yi-Ying Kuo, Zhongy ing Yang, Eleonora Grandi, Jian Gao, Grigory Maksaev, Jerod S. Denton, Katarzyna Walczewska-Szewc, Show-Ling Shyng, Colin G. Nichols 1142-Pos Board B316 ENGINEERED RAPAMYCIN RESPONSIVE K2P CHANNELS. Leila Kha joueinejad, Elena B. Riel, Karl F. Herold, Hugh C. Hemmings Jr., Rie Nygaard, Paul M. Riegelhaupt 1143-Pos Board B317 STRUCTURAL BASIS FOR THE SUBTYPE-SELECTIVE ACTIVATION OF K CA 3.1 CHANNELS. Alena Ramanishka , Young Woo Nam, Joshua Nasburg, Yang Xu, Meng Cui, Heike Wulff, Miao Zhang 1144-Pos Board B318 DISCOVERY OF A SMALL MOLECULAR MODULATOR OF THE CELLULAR TRAFFICKING OF THE KCNQ1 POTASSIUM CHANNEL. Charles R. Sanders , Katherine R. Clowes, Carlos G. Vanoye, Ana C. Chang-Gonzalez, Ian Romaine, Katherine M. Stefanski, Mason Wilkinson, Joshua Bauer, Thomas Hasaka, Reshma Desai, Kathryn R. Brewer, Gary Sulikowski, Alex Waterson, Jens Meiler, Kaitlyn V. Ledwitch, Alfred L. George 1145-Pos Board B319 A MEMBRANE-DISRUPTIVE ACTION OF VBIT-4 CHALLENGES ITS ROLE AS A WIDELY USED VDAC OLIGOMERIZATION INHIBITOR. Varun Ravis hankar, Luís Borges-Araújo, Elodie Lafargue, Deborah Byrne, Nicolas Buzhinsky, Mya S. Wolfe, Wendy Fitzgerald, Nina Bautista, Bethel Bey ene, Motahareh Ghahari Larimi, Jean-Pierre Duneau, James N. Sturgis, Megha Rajendran, Sergey M. Bezrukov, Ignacio I. Casuso, Tatiana K. Rostovtseva, Lucie A. Bergdoll 1146-Pos Board B320 CLASSIFICATION OF HCN1 MUTATION CLASSES GUIDES CORRECTIVE THERAPIES IN EIEE DYSFUNCTION. Anna Moroni , Roberta Castelli, Alessandro Porro, Anna Castellini, Andrea Saponaro, Dario DiFrancesco, Gerhard Thiel, Bina Santoro 1147-Pos Board B321 IS KCNA2 HAPLOINSUFFICIENT? Pei Xin Boon , Amaia Jauregi Miguel, Sumeyye Suheda Yasarbas, Serena Pozzi, Charmaine Ko, Amelle Shil lington, Antonios Pantazis

1148-Pos Board B322 ANTI-TUMORIGENIC EFFECT OF EAG1 CHANNEL INHIBITION BY AMI TRIPTYLINE. Joos Berghausen, Clementine A.D. Thomas , Ze-Jun Wang, Eric Glasgow, Tinatin I. Brelidze 1149-Pos Board B323 DE NOVO DESIGN OF ION CHANNEL MODULATORS USING DEEP LEARN ING FOR THERAPEUTIC APPLICATIONS. Diego Lopez Mateos , Hai M. Nguyen, Yang Zheng, Ryan L. Woltz, Matthew J. Marquis, Kush Narang, Adam Murray, Igor V. Vorobyov, Miao Zhang, Nipavan Chiamvimonvat, Heike Wulff, Vladimir Yarov-Yarovoy 1150-Pos Board B324 RECONSIDERING NATIVE PROTON CHANNEL COMPOSITION AND FUNC TION: AMYLOID PRECURSOR PROTEIN (APP) IS AN ACCESSORY SUBUNIT IN HV1 CHANNELS IN MICROGLIA. Yiwen Ding , Ruiming Zhao, Mahas weta Nayak, Steve A. Goldstein 1151-Pos Board B325 ATP SYNTHASE C-SUBUNIT LEAK CHANNEL ACTIVITY IN BIPOLAR DIS ORDER. Lei Shen , Jonghun Kim, Amrendra Kumar, Nelli Mnatsakanyan, Hilary P. Blumberg, In-Hyun Park, Elizabeth A. Jonas Skeletal Muscle Mechanics, Structure, and Regulation (Boards B326 - B335) 1152-Pos Board B326 DROSOPHILA JUMP MUSCLE MYOFIBRILS: A NEW TOOL FOR INVESTI GATING ACTIVATION AND RELAXATION. Axel J. Fenwick, Bernadette M. Glasheen, Anthony Cammarato, Douglas M. Swank 1153-Pos Board B327 SARCOMERE LENGTH AND FORCE BEHAVIOR IN SKELETAL MUSCLE MYOFIBRILS. Taiki Ino , Tim Leonard, Walter Herzog 1154-Pos Board B328 UNEXPLAINED AND REVERSIBLE Z-LINE WIDENING IN ISOLATED MYOFI BRILS AT LONG SARCOMERE LENGTHS. Chris Tiessen , Naomi Woyessa, Tim Leonard, Walter Herzog 1155-Pos Board B329 LABEL FREE QUANTITATIVE PHASE MICROSCOPY OF SKINNED MUSCLE FIBER. Ritwija Bhattacharjee , Riley Van Ravesteyn, Ana Espinosa-Mo mox, Rosario Porras-Aguilar, Yuri E. Nesmelov 1156-Pos Board B330 ROLE OF DYSFERLIN’S TRANSMEMBRANE AND EXTRACELLULAR DO MAINS IN REGULATING CALCIUM RELEASE IN MURINE SKELETAL MYO FIBERS. Valeriy I. Lukyanenko , Joaquin Muriel, Veronica Lukyanenko, Robert J. Bloch 1157-Pos Board B331 MYOSIN BINDING PROTEIN-C’S (MYBP-C) ROLE IN REGULATING CAR DIAC AND SKELETAL MUSCLE RESPONSES TO RAPID STRETCH. Nichlas M. Engels , Rachel Sadler, Samantha Harris 1158-Pos Board B332 DISTINCT EFFECTS OF ABLATION OF MYBP-C ON RELAXATION KINETICS OF SINGLE MYOFIBRILS FROM FAST AND SLOW TWITCH MUSCLES. Alexey V. Dvornikov , Samantha P. Harris 1159-Pos Board B333 Travel Award Winner DISTINCT STRUCTURAL DYNAMICS BETWEEN SLOW SKELETAL AND CARDIAC MYOSIN BINDING PROTEIN-C N-TERMINAL DOMAINS. Morgan M. Seffrood , Thomas. A Bunch, Victoria C Lepak, Brett A. Colson 1160-Pos Board B334 ALTERED DYNAMICS IN SKELETAL MYOSIN WITH PATHOGENIC MISSENSE MUTATIONS. Ka Fu Man , Arianna Fornili

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