BPS2026 Program Book

1112-Pos Board B286 TYPE 1 RYANODINE RECEPTOR PLAYS AN IMPORTANT ROLE IN CARDIAC HYPERTROPHY BY INCREASING TYPE 2 RYANODINE RECEPTOR-MEDI ATED CALCIUM RELEASE. Yong-Xiao Wang, Shey-Shing Sheu, Yun-Min Zheng 1113-Pos Board B287 GAP JUNCTIONAL COUPLING DEFINES THE ELECTRO-TRANSCRIPTIONAL IDENTITY OF ENDOTHELIAL CELLS. Pia C. Burboa , Veronica Kuzdowicz, Stefany Ordenes, Helmuth Sanchez, Mauricio A. Lillo 1114-Pos Board B288 LIPID INTERPLAY IN THE MODULATION OF HIPPOCAMPAL KIR3 CHAN NEL SIGNALING. Anna N. Bukiya, Avia Rosenhouse-Dantsker 1115-Pos Board B289 Travel Award Winner STRUCTURE AND MECHANISM OF THE HUMAN MITOCHONDRIAL MRS2 CHANNEL. Yung Chi Tu , Ming Feng Tsai 1116-Pos Board B290 FUNCTIONAL REGULATION OF THE NALCN SODIUM LEAK CHANNEL COMPLEX BY G PROTEINS. Hendrik Harms , Natasja Jacobsen, Ann Sofie Ploug, Stephan A. Pless 1117-Pos Board B291 MECHANISM OF KCNQ1 GATING REGULATED BY PIP 2 AND CALMODU LIN. Lu Zhao , Xianjin Xu, Chenxi Cui, Rui Duan, A.Kermani Ali, Jingyi Shi, Lu Han, Ji Sun, Xiaoqin Zou, Jianmin Cui 1118-Pos Board B292 MOLECULAR ARCHITECTURE OF THE FUNGAL-SPECIFIC POTASSIUM CHANNEL TOK1. Brice Durocher, Rían W. Manville, Rui Yan, Zhiheng Yu, Geoffrey W. Abbott, Alexandria N. Miller 1119-Pos Board B293 CA 2+ -DEPENDENT ACTIVATION OF THE TMEM16F SCRAMBLASE AND CHANNEL IN LIPOSOMES. Zhang Feng, Omar E. Alvarenga-Cruz, El eonora Di Zanni, Sangyun Lee, George Khelashvili, Alessio Accardi 1120-Pos Board B294 STRUCTURAL BASIS OF MG-NUCLEOTIDE REGULATION AND THE ROLE OF INTRINSICALLY DISORDERED REGIONS ON VASCULAR KIR6.1/SUR2B K ATP CHANNELS. Camden M. Driggers , Katarzyna Walczewska-Szewc, Sun Joo Lee, Yi-Ying M. Kuo, Zhongying Yang, Colin G. Nichols, Show-Ling Shyng Ion Channels, Pharmacology, and Disease I (Boards B295 - B325) 1121-Pos Board B295 Travel Award Winner TARGETING HASIC1A IN STROKE WITH DEEP LEARNING-GENERATED MINIPROTEINS. Janina Sörmann , Christina Latt Fjorbak, Maria Francesca Vicino, Samuel Usher, Bernadette Lang, Konstantina Epitropaki, Fabian Hink, Søren Friis, Joseph Rogers, Henriette Autzen, Changsi Cai, Stephan A. Pless 1122-Pos Board B296 PREDICTION OF TDP ARRHYTHMIA RISK THROUGH MOLECULAR SIMU LATIONS OF CONFORMATION-SPECIFIC DRUG INTERACTIONS WITH THE HERG K+, NAV1.5, AND CAV1.2 CHANNELS. Kyle C. Rouen , Kush Narang, Yanxiao Han, David Wang, Ensley Jang, Sophia Brunkow, Vladimir Yarov Yarovoy, Alexander D. MacKerell, Igor Vorobyov 1123-Pos Board B297 STRUCTURAL BASIS FOR THE SUBTYPE-SELECTIVE ACTIVATION OF K CA 2.2 CHANNELS. Young Woo Nam, Alena Ramanishka, Joshua Nasburg, Yang Xu, Rose Marie Haynes, Meng Cui, K George Chandy, Heike Wulff, Miao Zhang

1124-Pos Board B298 FENTANYL ACTIVATES CALCIUM- AND VOLTAGE-GATED POTASSIUM CHANNELS (BK) VIA THEIR BETA1 SUBUNITS. Mohammed M. Nooh, Shiwani Thapa, Akhil Geddati, Alex M. Dopico, Anna N. Bukiya 1125-Pos Board B299 A SHARED CAVITY SITE FOR LIPID AND SMALL MOLECULE BLOCK OF THE TWO PORE DOMAIN K+ CHANNEL TASK2. Trevor Docter , Ben Sorum, Baobin Li, Annan S.I. Cook, Robert A. RIetmeijer, Abhay Kotecha, Steve Travel Award Winner DIFFERENTIAL SURFACE-TRAFFICKING DEFICIENCY BY PROLINE-SUB STITUTION, EPILEPSY-ASSOCIATED, K V 1.2-CHANNEL ( KCNA2 ) VARI ANTS. Amaia Jauregi Miguel , Panagiota Gkotsi, Ferenc Török, Serena Pozzi, Varsha Prakash, Antonios Pantazis 1127-Pos Board B301 MOLECULAR MECHANISMS OF ACTIONS OF SK2 CHANNEL MODULA TORS FOR ATRIAL FIBRILLATION THERAPY. Woori Choi , Ryan L. Woltz, Miao Zhang, Igor V. Vorobyov, Nipavan Chiamvimonvat 1128-Pos Board B302 BEYOND CELL RECEPTORS: CATIONIC AMPHIPHILIC DRUG FINGOLIMOD MODIFIES LIPID MEMBRANES AND ION CHANNEL ACTIVITY. Antara Syam , Ekaterina M. Nestorovich, Tatiana K. Rostovtseva, John Choy, Sergey M. Bezrukov 1129-Pos Board B303 CRYO-EM AND FUNCTIONAL INVESTIGATION OF POLYCHLORINATED BIPHENYL COMPOUND BINDING TO RYANODINE RECEPTORS. Yongli ang Zhang, Qing Wang, Steven Molinarolo, Zhiguang Yuchi, Filip Van Board B304 SUPPRESSION OF THE AMPLIFYING PATHWAY IN KATP KNOCKOUT ISLETS. Nathaniel W. York , Maria S. Remedi, Colin G. Nichols 1131-Pos Board B305 CONSERVED CATION-Π INTERACTIONS IN VOLTAGE-SENSING DOMAINS PREVENT PATHOGENIC GATING-PORE CURRENTS ACROSS ION CHANNEL FAMILIES. Eslam Elhanafy , Sydney Menear, Ahmed Eltokhi, Jing Li 1132-Pos Board B306 MOLECULAR MODELING AND SIMULATIONS OF MUTANT CARDIAC SODIUM CHANNELS NAV1.5 FOR PATIENT-SPECIFIC ARRHYTHMIA TREATMENT. Yen-Her Lai , Kyle C. Rouen, Khoa Ngo, Adriana Hernández González, Vladimir Yarov-Yarovoy, Igor V. Vorobyov 1133-Pos Board B307 STRUCTURAL BASIS FOR THE MODULATION OF RYANODINE RECEPTORS BY CALCINS. Marvin T. Bader , Yuxuan Zhuang, Georgina Gurrola, Hector Valdivia, Erik R. Lindahl, Rebecca J. Howard, Filip Van Petegem 1134-Pos Board B308 HIGH-THROUGHPUT CARDIOTOXICITY SCREENING VIA OPTOPHYSIOL OGY OF VOLTAGE AND CALCIUM IN HIPSC CARDIOMYOCYTES. Elizabeth Vargas Ph.D. , Nicholas M. Radio, Brent Samson, Claudia Jaffe Ph.D. 1135-Pos Board B309 REDISCOVERING OLD FRIENDS: EXPLOITING ANCIENT PROTEIN ASSEM BLY FOR A NOVEL K ATP CHANNELOPATHY GENE THERAPY. Vini Nagaraj , Rosa Scala, Colin G. Nichols, Conor McClenaghan 1136-Pos Board B310 SUR2A-RESTRICTED VARIANTS CAUSE STRIATED MUSCLE K ATP CHANNEL DYSFUNCTION AND AN INSIDIOUS CARDIAC VULNERABILITY. Vini Naga raj, Kingsley C. Duru, Jacob A. Sievers, Joshua Matthew, Rosa Scala, Colin G. Nichols, Conor McClenaghan Brohawn 1126-Pos Board B300 Petegem 1130-Pos

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