BPS2026 Program Book

1345-Plat 11:00 am ENGINEERING NOVEL MUTANT PROTEINS OF THE NA + - I - SYMPORTER (NIS) TO BROADEN RADIOIODIDE THERAPY BEYOND THYROID CANCER. Alejandro Llorente-Esteban , Haswitha Sabbineni, Kendra Hoffsmith, Rían Manville, David López-González, Andrea Reyna-Neyra, Alfonso Leyva, Geoffrey Abbott, Mario A. Bianchet, Nancy Carrasco 1346-Plat 11:15 am STRUCTURAL BASIS OF UNCOUPLING IN A CLC TRANSPORTER. Sangyun Lee , Olga Boudker, Alessio Accardi 1347-Plat 11:30 am NOVEL LIPID RECOGNITION AND ACTIVATION MECHANISM OF A P4 ATPASE ELUCIDATED VIA CRYO-EM. Harsh Dutta , Nikhil Bharambe, Sandip Basak 1348-Plat 11:45 am MOLECULAR SIMULATIONS OF PROTON-COUPLED NEUROTRANSMIT TER TRANSPORT BY VMAT2. Carl-Mikael Suomivuori 1349-Plat 12:00 pm EXPLORING ADEC VARIANT DYNAMICS TO UNDERSTAND EFFLUX-ME DIATED RESISTANCE IN ACINETOBACTER BAUMANNII . Isik Kantarcioglu Mazmanoglu , Ata Göktug Çim, Ali Rana Atilgan, Canan Atilgan 1350-Plat 12:15 pm MOLECULAR BASIS OF THE COOPERATIVITY BETWEEN THE PRIMARY SUBSTRATE-BINDING AFFINITY AND CONFORMATIONAL DYNAMICS IN THE MELIBIOSE PERMEASE MELBST. Lan Guan , Yuqi Shi, Hariharan Parameswaran, Rosa Viner 1351-FlashTalk 12:30 pm TMEM65 RECONSTITUTES MITOCHONDRIAL NA + /CA 2+ EXCHANGE. Jim L. Zhang , Yu-Chen Chang, Liang Feng, Ming-Feng Tsai 1352-FlashTalk 12:35 pm MOLECULAR BASIS OF SUBSTRATE SPECIFICITY EVOLUTION IN ABCG2. Ever O’Donnell , Xujia Zhou, Sook Wah Yee, Kathy Giacomini, Robert Stroud, Willow Coyote-Maestas 1353-FlashTalk 12:40 pm INVESTIGATING THE STRUCTURAL DYNAMICS OF SUBSTRATE AND ION BINDING IN NACT. Noah Trebesch , Emad Tajkhorshid Platform Condensates from Biophysics to Disease II 10:45 am - 12:45 pm, Room 207/208 Co-Chairs Lucy D. Brennan, University of California, Berkeley, USA Gonen Golani, Haifa University, Israel 1354-Plat 10:45 am NUCLEATION KINETICS REVEALS A DISTINCT BIOLOGICAL FUNCTION SPACE OF BIOMOLECULAR CONDENSATES. Leif-Thore Deck , Sandra Navarro Pacheco, Hannes Ausserwöger, Daan Frenkel, Nadia A. Erkamp, Tuomas P.J. Knowles 1355-Plat 11:00 am Travel Award Winner MOLECULAR DETAILS OF RNA IN BIOMOLECULAR CONDENSATES. Tongyin Zheng , Kandarp A. Sojitra, Samara Cummings, Jeetain Mittal, Nicolas L. Fawzi 1356-Plat 11:15 am CONDENSATES PROVIDE A UNIQUE ENVIRONMENT FOR REDOX MEDIATED PROTEIN CROSSLINKING IN VITRO AND IN LIVE CELLS. Huan Wang , Bruna Favetta, Benjamin S. Schuster, Zheng Shi

1357-Plat Travel Award Winner DESIGNING ENZYMATIC REGULATION OF BIOMOLECULAR CONDEN SATES. Takumi Matsuzawa , Kaarthik Varma, Charlotta Lorenz, Teagan Bate, Dana Matthias, Etienne Jambon-Puillet, Eric Dufresne 1358-Plat 11:45 am CONTROLLING MULTIPHASE COACERVATE WETTING AND SELF-ORGA NIZATION BY INTERFACIAL PROTEINS. Tiemei Lu , Susanne Liese, Hagan Bayley, Wilhelm Huck, Christoph Weber, Evan Spruijt 1359-Plat 12:00 pm PROBING THE ROLE OF VASP CONDENSATES IN THE ASSEMBLY OF FILO PODIA AT THE LEADING EDGE OF MOTILE CELLS. Rahul Sharma , Caleb Walker, Kristin Graham, Jeanne C. Stachowiak 1360-Plat 12:15 pm RECONSTITUTING THE LIQUID-LIQUID INTERFACE OF CHROMATIN CON DENSATES. Lucy D. Brennan 1361-FlashTalk 12:30 pm ROLES OF HISTONE CHAPERONE NAP1 AND HISTONE ACETYLATION IN REGULATING PHASE-SEPARATION OF NUCLEOSOME ARRAYS. Jia Gao 1362-FlashTalk 12:35 pm A PHYSICS-BASED APPROACH TO PREDICT PHASE BEHAVIOR OF PRO TEINS UNDER HEAT STRESS. Ananya Chakravarti , Jerelle A. Joseph 1363-FlashTalk 12:40 pm INFERRING THE SURFACE PROPERTIES OF PROTEIN CLUSTERS THAT PRE CEDE LLPS FROM THEIR SIZE DISTRIBUTIONS. Gonen Golani , Samuel Safran Platform Co-Chairs Sebastian Michler, Martin Luther University, Germany Emily N. Weed-Nichols (Robinson), University of Rochester, USA 1364-Plat 10:45 am UNWINDING OF TRANSMEMBRANE HELIX-1 IS CRITICAL FOR DRUG EX PORT IN P-GLYCOPROTEIN. Nghi Tran , Lesly J. Ortiz Joya, Arne Moeller, Qinghai Zhang, Ina Urbatsch 1365-Plat 11:00 am FUNCTIONAL THERMODYNAMICS GOVERN THE LIGAND INTERACTIONS WITH HUMAN CYTOSOLIC TRANSPORT PROTEINS. Sebastian Michler , Christian Schwieger, Florian Arndt Schoeffmann, Dariush Hinderberger 1366-Plat 11:15 am Travel Award Winner VISUALIZING HIV-1 CAPSID STRUCTURAL CHANGES THROUGH TIME RESOLVED FLUORESCENCE MICROSCOPY AND CORRELATIVE CRYO-ELEC TRON TOMOGRAPHY. Zaida Rodriguez , Jonathan Andino-Moncada, Sergii Buth, Atousa Mehrani, Leonardo Andrade, Hamidreza Rahmani, Danielle A. Grotjahn, Gregory B. Melikian, Ashwanth Francis, Dmitry Lyumkis 1367-Plat 11:30 am Travel Award Winner DECODING PLD3: STRUCTURAL AND FUNCTIONAL DISCOVERIES WITH THERAPEUTIC POTENTIAL FOR ALZHEIMER’S DISEASE. Maria Eleni Georgopoulou , Kenta Ishii, Stefan Hermans, Tracy Nero, Nancy Hancock, Gabriela Crespi, Michael Gorman, Claire Weekley, Emma van der West huizen, Michael Parker 11:30 am Protein-Small Molecule Interaction 10:45 am - 12:45 pm, Room 209/210/211

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