BPS2026 Program Book

1368-Plat 11:45 am APPLICATION OF MOLECULAR DYNAMICS FOR DEVELOPMENT OF THERAPEUTICS AGAINST OPIOID OVERDOSE. Emily N. Weed-Nichols (Robinson) , Alexander Crook, Israel Burnell, Paulina Getsy, James M. Seckler, Stephen Lewis, Alan Grossfield 1369-Plat 12:00 pm NEURALBIND: SCALING AND DIVERSIFYING BINDING AFFINITY DATA VIA CO-FOLDING. Wei-Tse Hsu , Savva Grevtsev, Thomas Douglas, Aniket Magarkar, Philip C. Biggin 1370-Plat 12:15 pm 19 F NMR TO PROBE THE CRYPTIC POCKET IN ‘UNDRUGGABLE’ RAS LIKE GTPASES. Fatema Bhinderwala , Christina M. Monnie, Angela M. Gronenborn 1371-FlashTalk 12:30 pm ISOMERS OF COMMON COMPATIBLE OSMOLYTES ARE NOT OSMOLYTIC. Christina M. Othon , Beatrice Oey, Ximena Juarez Martinez, Sean Rath, Erika Taylor, Patrick Willoughby 1372-FlashTalk 12:35 pm MOLECULAR MODELING AND MACHINE LEARNING APPROACHES IN BETTER UNDERSTANDING OF (PRO)CATHEPSIN-GLYCOSAMINOGLYCAN INTERACTIONS. Krzysztof K. Bojarski 1373-FlashTalk 12:40 pm UTILIZING ALPHAFOLD2 MULTI-STATE MODELING FOR IMPROVING STRUCTURE-BASED DRUG DISCOVERY. Woong-Hee Shin , Jinung Song, Wonkyeong Jang, Juyong Lee Platform Actin and Microtubules: Structure, Dynamics and Regulation 10:45 am - 12:45 pm, Room 212/213/214 Co-Chairs Achyutha Krishna Pathri, CSIR-Centre for Cellular and Molecular Biology, India Ao Ma, University of Illinois at Chicago, USA 1374-Plat 10:45 am STRUCTURAL BASIS OF TUBULIN POST TRANSLATIONAL MODIFICA TION RECOGNITION BY EML PROTEINS. Aryan Taheri , Burak Cetin, Jon Fernandes, Ahmet Yildiz, Eva Nogales 1375-Plat 11:00 am IN VITRO RECONSTITUTION OF THE INTERPLAY BETWEEN THE TUBULIN- AND MAP- CODES AND THEIR EFFECTS ON KINESIN MOTILITY. Jon T. Fernandes , Viola Zhao, Parnika Kant, Ahmet Yildiz 1376-Plat 11:15 am Travel Award Winner STRUCTURAL BASIS OF SHRC REGULATION FOR ARP2/3 COMPLEX MEDIATED ACTIN FILAMENT NUCLEATION. Achyutha Krishna Pathri , Bojian Ding, Nipunika Rupasinghe, Debadutta Patra, Bayou Chen, Saikat Chowdhury 1377-Plat 11:30 am FORCE-MODULATED STRUCTURAL LANDSCAPE OF THE CATCH BONDING ACTIN CROSSLINKER Α-ACTININ-4. Alfred C. Chin , Fatemah Mukadum, Matthew J. Reynolds, Glen M. Hocky, Gregory M. Alushin 1378-Plat 11:45 am TETRATHYMOSINBETA (TTH-1) INHIBITS ACTIN ASSEMBLY THROUGH THE COORDINATED FUNCTION OF 4 TANDEM WH2 DOMAINS. Sarah M. Christensen , Hannah Ye, Claire Hornburg, Ondrej Maxian, Rachel Kadzik, Cristian Suarez, David Kovar, Allison Squires

1379-Plat 12:00 pm MECHANICAL FORCE LOCALLY DAMAGES, REMODELS AND STABILIZES THE LATTICE OF SPINDLE MICROTUBULES. Caleb J. Rux , Megan K. Chong, Valerie Myers, Nathan Cho, Sophie Dumont 1380-Plat 12:15 pm STRUCTURE-BASED MECHANO-CHEMICAL MODEL REVEALS HOW MICROTUBULES NUCLEATE FROM STABILIZED SEEDS. Ao Ma , Kenneth Tsui, Shannon F. Stewman 1381-FlashTalk 12:30 pm MICROTUBULE DAMAGE SENSOR SSNA1 REINFORCES THE MECHANI CAL STRENGTH OF MICROTUBULES. Laura B. Richardson , Elizabeth Lawrence, Abinaya Pinjakan, Marija Zanic 1382-FlashTalk 12:35 pm AQUEOUS TRANSIENT PHASE SEPARATED MODEL SYSTEMS AND THEIR INTERPLAY WITH ACTIN. Archan Vyas , Christopher F. Carnahan, Michael Pham, Roanna Pham, Changyang Zhang, Victor Hernandez, Jasmine Doyle, Riya Kaur Sandhu, Eliza Morris, Mikkel H. Jensen, Atul N. Parikh 1383-FlashTalk 12:40 pm INSIGHTS INTO HOW THE STRUCTURE OF ACTIN FILAMENTS MODU LATES THE RATE OF PHOSPHATE (PI) RELEASE POST-HYDROLYSIS. Kristina M. Herman , Sahithya Sridharan Iyer, Yihang Wang, Thomas D. Pollard, Gregory A. Voth Exhibitor Presentation Sophion Bioscience 11:30 am - 1:00 pm, Esplanade, Room 157 Expanding the Reach of Automated Patch Clamp: From Computational Design to Organellar and Natural Product Ion Channel Assays Automated patch clamp (APC) technology has transformed ion channel research by enabling high-throughput, high-fidelity electrophysiologi cal recordings that were once limited to manual approaches. Sophion Bioscience, a leader in APC instrumentation, continues to push the boundaries of what can be measured; from complex primary cell assays to challenging organellar and transporter recordings. This exhibitor hosted event highlights recent advances and diverse applications of APC across academic and translational research. Dr. Hai Minh Nguyen (UC Davis) will discuss how computational peptide design and APC-based functional validation can accelerate the develop ment of selective ion channel modulators. Dr. Daniel Sauter (Sophion Bioscience) will present new APC workflows optimized for recording small current amplitudes such as single channels and transporters. Dr. Rian Manville (UC Irvine) will demonstrate how APC enables systematic screening and characterization of plant-derived compounds with ion channel activity. Together, the speakers will illustrate how innovations in automated patch clamp technology are driving new directions in ion channel dis covery, from molecular design and assay development to translational applications. Speakers Rian Manville, Assistant Project Scientist, University of California, Irvine Hai Nguyen, Associate Project Scientist, University of California, Davis Daniel Sauter, Application Science Manager, Sophion Bioscience

T U

E S

D A Y

111