BPS2026 Program Book

1491-Pos Board B28 LIPID COMPOSITION MODULATES THERMAL STABILITY AND FUNC TION OF CYTOCHROME P450 2J2 IN NANODISCS. Rajatabha Das , Henry Mastrion, Aditi Das 1492-Pos Board B29 HIGH-THROUGHPUT SCREENING TOOLS FOR STUDYING AUTOTRANS PORTER SECRETION. Disha Patel , Patricia L. Clark 1493-Pos Board B30 ELECTROSTATIC DIVERGENCE AND LOCAL PACKING UNDER PRESSURE: MECHANISMS OF DEEP-SEA EXONUCLEASE ADAPTATION. Tejaswi Naidu Koduru , Noam Hantman, Philippe Barthe, Karine De Guillen, Scott A. McCallum, Joel E. Morgan, Estella Yee, Pierce Leonardi, Jack Foland, Christian Roumestand, Catherine A. Royer 1494-Pos Board B31 DEVELOPING CHEMICAL TOOLS TO EXPLORE HOW SITE-SPECIFIC UBIQUITINATION DRIVES PROTEIN DESTABILIZATION AND INFLUENCES AMYLOID FORMATION. Jeslyn S. Hopham , Johan Villalpando Farach, Natalie Dinh, Angelika Caraballo, Emiliano Ruiz, Regina Leyva Roman, Hannah Suazo, Nate Bazan, Emma Carroll 1495-Pos Board B32 DISCOVERING CHEMICAL DETERMINANTS OF P53 AMYLOID FORMA TION. Anushree Bhattacharya , Trang Pham, Jasmine Trinh, Kashish Airen, Katherine Hoang, Nha-Quyen Nguyen, Aseel Alagtash, Emma Carroll 1496-Pos Board B33 THERMAL AND PH STABILITY OF PHI-6 BACTERIOPHAGE P5 LYSIS PRO TEIN AND ITS VARIANTS. Elizabeth A. Wyatt , Andrew Le, Ningkun Wang 1497-Pos Board B34 THE ROLE OF CANCER-ASSOCIATED PHYSICOCHEMICAL CHANGES FOR PROTEIN STRUCTURE AND AGGREGATION. Giovana Casteluci Moreira , Fernando Alves de Melo, Pernilla Wittung-Stafshede 1498-Pos Board B35 COMPREHENSIVE IDENTIFICATIONOF TEMPERATURE-SENSITIVE GPCRS THAT ARE CHAPERONED BY APPROVED DRUGS. Sohan Shah , Austin Ted man, Caden Sillman, Muskan Goel, Matthew Howard, Eli F. McDonald, Brianna Corman, Joseph P. Robinson, Madan Babu, Aashish Manglik, Charles P. Kuntz, Willow Coyote-Maestas, Jonathan P. Schlebach 1499-Pos Board B36 PROBING THE EVOLUTION OF DESICCATION RESISTANCE IN TARDI GRADE ADENYLATE KINASES. Yuling Gu , Mark Petersen, Susan Marqu see 1500-Pos Board B37 MAPPING INTERACTIONS OF RESIDUAL WATER IN DRY PROTEIN BY SOL ID-STATE X-RAY FOOTPRINTING MASS SPECTROMETRY (SSXFMS). Mark Petersen , Sayan Gupta, Corie Ralston, Susan Marqusee 1501-Pos Board B38 COMPUTATIONAL MAPPING OF PRION PROTEIN MISFOLDING HOTSPOTS: INSIGHTS FROM ENTROPY AND SIMULATION. Alessandro Cembran , Pedro Fernandez-Funez 1502-Pos Board B39 Travel Award Winner INTEGRATED STRUCTURAL BIOLOGY PROVIDES INSIGHT INTO THE FOLDING-SENSING MECHANISM OF UGGT1, THE GATEKEEPER OF GLYCOPROTEIN FOLDING IN THE ENDOPLASMIC RETICULUM. Robert V. Williams , Lila M. Gierasch

1503-Pos Board B40 NOVEL MECHANISTIC DIVERGENCE OF THE HSP70-HSP110 CHAPERONE SYSTEM IN FUNGI AND HUMANS. Justin M. Kidd , Ayil Perrott, Cancan Sun, Anusri Arun Prasath, Spoorti Kalashetti, Vadim Barnakov, Sky Evans, Qinglian Liu 1504-Pos Board B41 EXPLORING THE DYNAMICS OF SECA/SECB-DEPENDENT TRANSLOCA TION IN E. COLI USING SINGLE-MOLECULE TRACKING. Linnea Wikström , Tora Hävermark, Ivan L. Volkov, Erik Lundin, Mikhail Metelev, Gerrit Brandis, Magnus Johansson 1505-Pos Board B42 STRUCTURAL AND DYNAMIC INSIGHTS INTO NASCENT-PROTEIN IN TERACTIONS WITH THE TRIGGER FACTOR CHAPERONE. Neomi Millan , HONGQING GUAN, Zhemin Zhang, Edward W. Yu, Silvia Cavagnero 1506-Pos Board B43 TOWARDS A DETAILED MOLECULAR PICTURE OF CO-TRANSLATIONAL FOLDING DURING REAL-TIME TRANSLATION. Amir Bitran , Carlos Busta mante, Susan Marqusee 1507-Pos Board B44 STRUCTURAL PLASTICITY OF RSV NS1 PROTEIN MAY AS A DRIVER OF MULTIFUNCTIONALITY. Jiawei Dong, Celia Ait-Mouhoub, Alexis Verger, Monika Bajorek, Christina Sizun 1508-Pos Board B45 SURVEYING THE SEQUENCE CONSTRAINTS OF FOLDING ON THE RIBO SOME BY DEEP MUTATIONAL SCANNING. Rohan Bhardwaj , Caden Sillman, Charles P. Kuntz, Brianna Corman, Joseph P. Robinson, Jonathan P. Schlebach Membrane Protein Structure II (Boards B46 - B61) 1509-Pos Board B46 PROBING THE TOPOLOGY OF MEMBRANE-BOUND KRAS AND RAF US ING MULTIPLE BIOPHYSICAL APPROACHES. Andrew G. Stephen , Que Van, Frank Heinrich, Jason W. Sidabras, Erik K. Larsen, Thomas Schmidt, Mark McLean, Stephen G. Sligar 1510-Pos Board B47 STRUCTURE AND MEMBRANE INTERACTIONS OF TWO HELICES FROM MYCOBACTERIUM TUBERCULOSIS FTSL, ONE TRANSMEMBRANE AND ONE AMPHIPATHIC. Jiaxing Fan, Ramesh Prasad , Wenhao Hu, Timothy A. Cross, Rongfu Zhang, Huan-Xiang Zhou, Yan-Yan Hu 1511-Pos Board B48 POLYMERIC NANODISCS PRESERVE HERPESVIRAL MEMBRANE GLYCO PROTEIN CONFORMATION. Brian Cieslewicz , Ekaterina Heldwein 1512-Pos Board B49 STRUCTURES OF P-GLYCOPROTEIN BOUND TO CIS- AND TRANS FLUPENTIXOL REVEAL THE MECHANISM OF MODULATION OF INHIBI TION. Chao-Ming Hsieh , Jingyu Zhan, Allison B. Lupatkin, Lothar Esser, Suresh V. Ambudkar, Rick Huang, Michael Gottesman, Di Xia 1513-Pos Board B50 AN ACTIVE ALLOSTERIC MECHANISM IN ASAP1-MEDIATED ARF1 GTP HYDROLYSIS REDEFINES PH DOMAIN’S FUNCTION. Olivier Soubias , Samuel Foley, Xiaoying Jian, Rebekah Jackson, Yue Zhang, Eric M. Rosenberg, Benjamin Hu, Margaret E. Johnson, Alexander J. Sodt, Paul Randazzo, Robert A. Byrd 1514-Pos Board B51 THE ALTERED STOICHIOMETRY OF A NON-INACTIVATING MUTANT SUG GESTS THE ASSEMBLY SEQUENCE OF THE MECHANOSENSITIVE CHAN NEL MSCS. Elissa Moller , Madolyn Britt, Andriy Anishkin, Olga Boudker, Sergei Sukharev, Doreen Matthies

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