BPS2026 Program Book

1721-Pos Board B258 DYNAMIC REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILITY AND FUNCTION THROUGH VDAC COMPLEXATION WITH CYTOSOLIC PROTEINS. Megha Rajendran , Kaitlin Abrantes, Bethel G. Beyene, Nina A. Bautista, Jennifer D. Petersen, Wendy Fitzgerald, Wil liam M. Rosencrans, Sergey M. Bezrukov, Tatiana K. Rostovtseva 1722-Pos Board B259 ESTROGEN RECEPTOR MODULATORS AFFECT MITOCHONDRIAL PHYSI OLOGY THROUGH THE VOLTAGE-DEPENDENT ANION CHANNEL. Mya S. Wolfe , Sergey M. Bezrukov, Tatiana K. Rostovtseva, Wendy K. Fitzgerald, Megha K. Rajendran, Martha Bosch, Scotty Farley, Per Haberkant, Frank Stein, Carsten Schultz, Martin Kelley 1723-Pos Board B260 VDAC ISOFORM-SPECIFIC MODULATION OF MITOCHONDRIA STRUC TURE AND FUNCTION. Nina A. Bautista , Jennifer D. Petersen, Wendy Fitzgerald, Sergey M. Bezrukov, Tatiana K. Rostovtseva, Megha Rajen dran Voltage-Gated Channels Selective for Na or Ca (Boards B261 - B286) 1724-Pos Board B261 ARE PHENYLPROPENES A NEW CLASS OF BLOCKERS FOR VOLTAGE-GAT ED SODIUM CHANNELS? Joao L. Carvalho-de-Souza 1725-Pos Board B262 CAM - IQ MOTIF COMPLEX PROTECTS NA V 1.5 FUNCTION FROM CHANG ES IN CYTOSOLIC PH THROUGH H1915. Taylor A. Agee , Sara Garcia, Garrett Knotts, Spencer Lile, Christopher N. Johnson 1726-Pos Board B263 BIOPHYSICAL CHARACTERIZATION OF THE NAV1.5/L828F VARIANT ACROSS NEONATAL AND ADULT CONTEXTS IN A NAV1.5 IPSC-KO MODEL. Quentin Plumereau , Mohamed Chahine 1727-Pos Board B264 VALIDATION OF ANTIBODY TOXIN FUSIONS AGAINST SODIUM CHAN NELS. Alexander S. Haworth, Jose Enrique Gonzalez-Prada, Jacob Browne, Christopher W. Mathes , Tony Rush, Paul Miller, Edward Stevens 1728-Pos Board B265 CHARACTERIZATION OF DOMAIN III R1129Q HYPOKALEMIC PERIODIC PARALYSIS MUTATION IN HNAV1.4. James R. Groome 1729-Pos Board B266 BIOPHYSICAL CHARACTERIZATION OF THE NA V 1.9 NA + CHANNEL IN HU MAN SENSORY NEURONS. Patrick Shi , Tamara Cotta, Ian Orozco, Fanny Chan, Yannick Miron, Richard P. Kondo, Andrea Ghetti, Kevin Carlin 1730-Pos Board B267 INVESTIGATING SUMOYLATION-MEDIATED REGULATION OF NAV1.4 THROUGH FRET. Vishwa Madhusudhanan 1731-Pos Board B268 ASSESSMENT OF BIOMOLECULAR FOUNDATION MODELS IN PRE DICTING SMALL MOLECULE - VOLTAGE GATED ION CHANNEL COM PLEXES. Brandon J. Harris , Amogh Sukhthankar, Adriana Hernández González, Vladimir Yarov-Yarovoy 1732-Pos Board B269 DO LIKE ELECTRIC CHARGES REPEL EACH OTHER IN A VOLTAGE SENSI TIVE ION CHANNEL? H. Richard Leuchtag

1733-Pos Board B270 FUNCTIONAL ANALYSIS OF COMPOUND HETEROZYGOUS VARIANTS IN SCN4A ASSOCIATED WITH NEONATAL DEATHS. Yuna Mizobata , Saki Hayashi, Miho Kanawa, Satoe Takahashi, Andrea Hadjipanteli, Kazuaki Homma, Carolina Sismani, Masanori P. Takahashi, Tomoya Kubota 1734-Pos Board B271 MOLECULAR DYNAMICS SIMULATIONS OF NAV1.4 IN A CLOSED-STATE CONFORMATION REVEAL VOLTAGE SENSOR DYNAMICS. Gourav Saha , J. Alfredo Freites, Francesco Tombola, Steve C. Cannon, Douglas J. Tobias 1735-Pos Board B272 INVESTIGATING THE ROLE OF SCN1B IN THE REGULATION OF ACTION POTENTIAL PROLONGATION. Erica Marquez , Jonathan R. Silva 1736-Pos Board B273 Travel Award Winner STATE- AND USE-DEPENDENT INHIBITION OF NA V 1.7 BY POLYSORBATE 80: A COMPARATIVE ASSESSMENT OF TRITON X-100, NP-40, AND PEG. Ryeong-Eun Kim , Jin-Sung Choi 1737-Pos Board B274 SUMO MODULATION OF NAV CHANNELS. Elizabeth Scholl , Vishwa Mad husudhanan, Kirin Gada, Leigh D. Plant 1738-Pos Board B275 PORE MUTATIONS IN VOLTAGE-GATED SODIUM CHANNELS STA BILIZE THE CHANNELS PERMANENTLY IN THE SLOW INACTIVATED STATE. Yichen Liu , Francisco Bezanilla 1739-Pos Board B276 VSD III AS THE KEY REGULATOR OF EXCITATION-CONTRACTION COU PLING IN CAV1.1. Simone Pelizzari , Marta Campiglio, Monica Fernán dez-Quintero, Martin C. Heiss, Petronel Tuluc, Bernhard E. Flucher 1740-Pos Board B277 CELL-FREE EXPRESSION AND ELECTROPHYSIOLOGY PLATFORMS FOR FUNCTIONAL ANALYSIS OF MEMBRANE PROTEINS. Adam Laurence , Steven Hoang-Phou, Aleksandr Noy, Matthew A. Coleman 1741-Pos Board B278 ATOMIC SIGNATURES OF ADAPTATION: TETRODOTOXIN-RESISTANT SODIUM CHANNELS IN SNAKES. Kait Malewicz , Julia M. Montgomery, Joel W. McGlothlin, Justin A. Lemkul 1742-Pos Board B279 INVESTIGATING NAV1.5 VARIANTS AS PIP 2 CHANNELOPATHIES. Kirin D. Gada , Ana Santa Cruz 1743-Pos Board B280 ELUCIDATING THE CROSS-TALK BETWEEN PHOSPHORYLATION ANDDIS EASE-CAUSING MUTATIONS IN FAST INACTIVATION OF VOLTAGE-GATED SODIUM CHANNELS. Shiva Akhlaghi , Jing Li 1744-Pos Board B281 Travel Award Winner MODULATION OF THE CARDIAC SODIUM CHANNEL NAV 1.5 BY THE SEA ANEMONE PEPTIDE ANTHOPLEURIN A (APA). Gewil Daniella O. Allas , Adel K. Hussein, Sebastien F. Poget 1745-Pos Board B282 REVISITING THE VALENCE SELECTIVITY OF CALCIUM ION CHANNELS: A COMPUTATIONAL STUDY. Lingfeng Xue, Chen Song 1746-Pos Board B283 DEVELOPMENT OF DIGITAL TWINS FOR L-TYPE CALCIUM CHANNEL INHI BITION. Aleena Siritanapivat , Adriana Hernández González, Khoa Ngo, Kyle C. Rouen, Igor V. Vorobyov, Vladimir Yarov-Yarovoy

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