BPS2026 Program Book

1747-Pos Board B284 THE ROLE OF THE C-TERMINAL DOMAIN IN NAVSP1 CHANNEL MODU LATION BY TEMPERATURE. Angel Zavala Custodio, Carlos Gonzalez-Leon, Vikram K. Mulligan, Gerhard Hummer, Sonya M. Hanson, Andres Jara Board B285 INVESTIGATING THE ROLE OF VOLTAGE-GATED SODIUM CHANNEL GENE SCN1B IN OXIDATIVE STRESS USING HIPSC DERIVED CARDIOMYO CYTES. Zachary Williams , Erica Marquez, Matthew Loftus, Jonathan R. Silva 1749-Pos Board B286 CA V 1.2 EF-HAND AND IQ DOMAIN VARIANTS OF UNCERTAIN SIGNIFI CANCE (VUS) AFFECT CA 2+ CURRENT AND CA 2+ HOMEOSTASIS DIFFER ENTLY. Agnieszka Dyrda , Yuan-Chin Lee, Chek-Ying Tan, Chai-Ann Ng, Jamie I. Vandenberg, Filip Van Petegem, Livia C. Hool TRP Channels (Boards B287 - B310) 1750-Pos Board B287 SYNERGISTIC MODULATION OF TRPA1 ION CHANNEL BY CANNABI DIOL AND OLEOCANTHAL: A PHARMACOLOGICAL AND MECHANISTIC STUDY. Evangelos Dadiotis , Ziyue Meng, Lida Vagiaki, Meng Cui, Kiriaki Sidiropoulou, Prokopios Magiatis, Diomedes E. Logothetis 1751-Pos Board B288 MD SIMULATION REVEALS ION-SPECIFIC MODULATION OF LIGAND INDUCED TRPA1 ACTIVATION BY PIP 2 . Ziyue Meng , Evangelos Dadiotis, Meng Cui, Diomedes E. Logothetis 1752-Pos Board B289 PROTON INDUCED CONFORMATIONAL DYNAMICS OF TRPV1 REVEALED BY SMFRET. Ambika Krishnamoorti , Briar Bell, Vladimir Berka, Julio F. Cordero-Morales, Vasanthi Jayaraman 1753-Pos Board B290 DE NOVO DESIGN OF FUNCTIONAL MINI-BINDERS FOR TRPV1 MODULA TION. Zhihao Yao , Adriana Hernández González, Phuong Tran Nguyen, Vladimir Yarov-Yarovoy, Jie Zheng 1754-Pos Board B291 PROBING TEMPERATURE DEPENDENT STRUCTURAL DYNAMICS OF THE HUMAN TRPV1 VOLTAGE SENSOR LIKE DOMAIN IN MEMBRANE MIMETICS VIA SITE DIRECTED SPIN LABELING AND CW EPR SPECTROS COPY. Prameesha Perera , Evelyn A. Okorafor, Andrew K. Morris, Indra D. Sahu, Gary A. Lorigan 1755-Pos Board B292 TARGETING THE TRPV1-CALMODULIN INTERACTION: A POTENTIAL STRATEGY TO TREAT INFLAMMATORY AND NEUROPATHIC PAIN. Léna Serradeill , Yann Chappe, André Garenne, Florence Poulletier De Gannes, Annabelle Hurtier, Patricia Nabos, Rosa Orlacchio, Isabelle Lagroye, Yann Percherancier 1756-Pos Board B293 DYNAMIC ANALYSIS OF ION CHANNEL GATING USING BRET: UNVEILING TEMPORAL SIGNATURES FOR DRUG DISCOVERY. André Garenne, Sandra Pierredon, Yann Chappe, Vincent Compan, Yann Percherancier 1757-Pos Board B294 Travel Award Winner HALOTAG-BASED APPROACH TO QUANTIFYING SUBCELLULAR LOCAL IZATION OF TRPV3 CHANNELS. Alexander J. Holloway , Joshua Chiang, Andres Jara Oseguera, Eric N. Senning 1758-Pos Board B295 TRPV4 CHANNEL ACTIVATION BY PHORBOL 12-MYRISTATE 13-ACETATE (PMA): NEW INSIGHTS INTO TRPV4 CHANNEL ACTIVATION AND REGU LATION. Aravind Parthasarathy , Gayathri K. Natarajan, Irina Talyzina, Alexander I. Sobolevsky, Wai-Meng Kwok, David X. Zhang Oseguera 1748-Pos

1759-Pos Board B296 CRYO-EM STRUCTURE OF TRPM1 REVEALS A NON-CANONICAL ARCHI TECTURE WITH AN INVERTED TRANSMEMBRANE DOMAIN. Michael Fabrizio, Mackenzie R. Brewer , Chen Zhao 1760-Pos Board B297 MOLECULAR MECHANISMS OF TRPM1 REGULATION BY HETEROTRI MERIC G-PROTEIN. Chen Zhao, Michael Fabrizio, Colin C. Frank , Mack enzie Brewer, Jermaine Johnston 1761-Pos Board B298 LIPID REGULATION OF THE NOCICEPTIVE ION CHANNEL TRPM3. Matthew C. Denley , Kenton J. Swartz 1762-Pos Board B299 HEAT- AND PIP2-DEPENDENT TRPM4 ACTIVITY UNDERLIES MUTUALLY EXCLUSIVE HUMAN DISEASES. Yuhua Tian , Soohyeon Bae, Xuesong Wu, Kyle C. Rouen, Adriana Hernández González, Yanxiao Han, Abdullah A. Tekreeti, Simon Vu, Igor V. Vorobyov, Vladimir Yarov-Yarovoy, Byung Chang Suh, Sam Hwang, Jie Zheng 1763-Pos Board B300 TRPM7 KINASE CONTROLS CARDIAC INFLAMMATION IN A MODEL OF HEART FAILURE WITH PRESERVED EJECTION FRACTION. Man Liu , Hong Liu, Gyeoung-Jin Kang, Eunji Kim, Yugene G. Gao, Mitchell Neumann, Feng Feng, Samuel C. Dudley 1764-Pos Board B301 VARIANT SCORING IN A DEEP MUTATIONAL SCAN OF TRPM8 USING VECTOR PROJECTION. Vincent Le , Averi Pike, Andres Jara Oseguera 1765-Pos Board B302 COLD ACTIVATION OF TRPM8 USING HIGH THROUGHPUT AUTOMATED PATCH CLAMP. Maria Giustina Rotordam, Jan Rathje, Nadine Becker, Alison Obergrussberger , Søren Friis, Irene Lu, Timothy Strassmaier, Michael George, Niels Fertig 1766-Pos Board B303 RATIONAL TUNING OF TEMPERATURE SENSITIVITY IN THE TRPM8 CHANNEL. Lizhen Xu, Xiao Liang, Yunfei Wang, Han Wen, Shilong Yang, Tiannan Guo, Yi Zhu, Fan Yang 1767-Pos Board B304 MECHANISTIC INSIGHTS INTO TRPM8 GATING USING DEEP MUTATION AL SCANNING OF PORE REGIONS. Averi Pike , Vincent Le, Andres Jara Board B305 TRPM8 PROTEIN DYNAMICS SERVE AS A PREDICTIVE BRIDGE BETWEEN LIGAND STRUCTURE AND CELLULAR FUNCTION. Wade D. Van Horn , Mubark D. Mebrat, Dustin D. Luu 1769-Pos Board B306 TRPV4 CHANNELS EXPRESSED IN TRIGEMINAL AB LOW-THRESHOLD MECHANORECEPTORS MODULATE CHRONIC ITCH. Clara Bourgy, Thibaud Parpaite, Solène Barbeau, Kenza Azmani-Matar, Isabelle Lambermont, Xavier Yerna, Olivier Schakman, Philippe L. Gailly, Roberta Travel Award Winner DIFFRACTED X-RAY TRACKING REVEALS LIGAND- AND TEMPERATURE DEPENDENT C-TERMINAL DYNAMICS OF TRPM8. Haruto Machida , Tatsunari Ohkubo, Daisuke Sasaki, Hiroshi Sekiguchi, Kazuhiro Mio, Yuji C. Sasaki 1771-Pos Board B308 LIPID SELECTIVITY IN TRPV1 IS A KEY DETERMINANT OF CHANNEL MATURATION. Eric N. Senning , Benjamin He, Prateeti Varanasi, Nia Barkum, Rose Hudson Oseguera 1768-Pos Gualdani 1770-Pos Board B307

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