BPS2026 Program Book

1797-Pos Board B334 ESTABLISHING A FRET-BASED PLATFORM FOR MONITORING MECHA NOSENSITIVE PROTEIN CONFORMATIONAL DYNAMICS. Tomoya Mukai , Yasushi Okada 1798-Pos Board B335 HIGH-THROUGHPUT EVALUATION OF PIEZO1 PHARMACOLOGY USING THE AUTOMATED PATCH CLAMP M-STIM APPROACH. Timothy Strassmaier , Reetta Penttinen, Nicoletta Murciano, Maria Giustina Rotordam, Nadine Becker, David J. Beech, Lars Kaestner, Nicolas Rosa, Nicolas Demaurex, Vincent Jaquet, Markus Rapedius, Søren Friis, Mi chael George, Niels Fertig 1799-Pos Board B336 MODULATION OF PIEZO2 CHANNELS BY THE SMALL MOLECULE YODA1. Tharaka D. Wijerathne , Aashish Bhatt, Aneesh Chan drasekharan, Yun Lyna Luo, Jerome J. Lacroix 1800-Pos Board B337 TWIST IS THE KEY TO THE GATING OF MECHANOSENSITIVE ION CHAN NEL NOMPC. Jingze Duan , Chen Song 1801-Pos Board B338 MSCM USES A NOVEL GATING MECHANISM FOR BACTERIAL MECHANO SENSITIVE CHANNELS. Giorgos Hiotis , Thomas Walz 1802-Pos Board B339 TMC1 AND TMC2 ARE CHOLESTEROL-DEPENDENT SCRAMBLASES THAT REGULATE MEMBRANE HOMEOSTASIS IN AUDITORY HAIR CELLS. Hu bert Lee , Yein Christina Park, Jayashree Balaraman, Angela Ballesteros 1803-Pos Board B340 Travel Award Winner FUNCTIONAL HETEROMERIZATION OF MAMMALIAN PIEZO CHAN NELS. Aneesh Chandrasekharan , Tharaka D. Wijerathne, Ipek Midil lioglu, Roshiel D. Guzman, Ariga Tahmasian, Louis-Philippe Guinard, Michelle Digman, Jerome J. Lacroix 1804-Pos Board B341 TURGOR-DRIVEN RECOVERY OF THE BACTERIAL MECHANOSENSITIVE CHANNEL MSCS LEADS TO ITS COMPACT CLOSED STATE. Andriy Anish kin, Kenjiro Yoshimura, Elissa Moller, Madolyn Britt, Sergei I. Sukharev Cardia Muscle Regulation (Boards B342 - B359) 1805-Pos Board B342 MICROTUBULE CONTRIBUTIONS TO FORCE FREQUENCY MODULATION OF CARDIAC OUTPUT IN A MODEL OF DIASTOLIC HEART DISEASE. Emmaleigh N. Hancock , Julia E. Shrier, Melinda M. Wetzel, Raihan Kabir, Bradley M. Palmer, Matthew A. Caporizzo 1806-Pos Board B343 Travel Award Winner THE SWEET TASTE RECEPTOR REGULATES CARDIOMYOCYTE BIOENER GETICS. Micah W. Yoder , Maria Papadaki, Evan Kelly, Ahmed G.A. Zied, Brandon Markle, David Minh, Grace K. Muller, Jonathan A. Kirk 1807-Pos Board B344 PROTEIN TYROSINE PHOSPHATASE 1B AS A NOVEL REGULATOR OF MYO FILAMENT FUNCTION. Michaela M. Door , Marisa J. Stachowski, Yan Sun, Hana Pak, Laura A. Sherer, Maria Kontaridis, Jonathan A. Kirk 1808-Pos Board B345 ELUCIDATION OF THE FUNCTION OF ZEBRAFISH P63RHOGEF FOR THE SEARCH OF INHIBITORS OF P63RHOGEF. Kumiko Sakai , Yukari Tanae, Riyo Kajimoto, Masaya Hirota, Ko Momotani 1809-Pos Board B346 ALPHAFOLD AND MOLECULAR DYNAMICS MODELING OF THE DESEN SITIZATION OF THE CARDIAC TROPONIN COMPLEX BY TNI PHOSPHORY LATION AND EPIGALLOCATECHIN-3-GALLATE BINDING. Helene Tigro, Christopher Solís

1810-Pos Board B347 THE D73N TROPONIN C MOUSE: A TRANSLATIONAL MODEL OF DILATED CARDIOMYOPATHY WITH MITOCHONDRIAL ROS AND NOVEL ATRIAL MYXOMAS. Ali Ulker , Amelia Van Aelst, Jordan King, Radmila Terentye va, Fruzsina Perger, Anastasia Pokrass, Svetlana Tikunova, Peter Reiser, Sandor Gyorke, Dmitry A. Terentyev, Jonathan P. Davis 1811-Pos Board B348 A NONCANONICAL ROLE FOR NEPRILYSIN: CLEAVAGE OF PHOSPHOL AMBAN IN HEART FAILURE. Jacob D. Cunningham , Taylor Phillips, Seby Edassery, Seth L. Robia, Kush Nagrani 1812-Pos Board B349 TOXIC COMPETITORS OF PHOSPHOLAMBAN CONTRIBUTE TO DYSREGU LATION OF SERCA IN DILATED CARDIOMYOPATHY. Taylor A. Phillips , Jacob D. Cunningham, Mary D. Hernando, Seby Edassery, Howard S. Young, Jonathan A. Kirk, Seth L. Robia 1813-Pos Board B350 MOLECULAR AND STRUCTURAL CHARACTERIZATION OF A PEDIATRIC DILATED CARDIOMYOPATHY MOUSE MODEL BEARING TNNC1-I4M VARIANT. Paula Nieto Morales , Nichika Holdrum, Andrew Reilly, Olu wanifemi Bankole, Marie-Cecile Derbes, Huan He, Hao Zhang, Maicon Landim-Vieira, Weikang Ma, Christopher Solís, Vitold Galkin, Prescott B. Chase, J. Renato D. Pinto 1814-Pos Board B351 PKA PHOSPHORYLATION OF CTNI INCREASES POWER OUTPUT IN NON-PHOSPHORYLATABLE CMYBP-C PERMEABILIZED CARDIAC MYO CYTES. Laurin M. Hanft , Hannah Clevenger, Kerry S. McDonald 1815-Pos Board B352 THE C1-M REGION OF CARDIAC MYOSIN-BINDING PROTEIN-C FORMS A CRITICAL DAMPING MODULE THAT SUPPRESSES SARCOMERIC OSCILLA TIONS. Dylan L. Reichert , Nichlas M. Engels, Samantha P. Harris 1816-Pos Board B353 TARGETING MYOSIN-BINDING PROTEIN C BY A HIGH-THROUGHPUT AP PROACH FOR CARDIOMYOPATHY THERAPEUTICS. Piyali Guhathakurta , Thomas. A Bunch, Andrew L. Thompson, Victoria C Lepak, Anna L Carter, Jennifer J Thomas, Brett A Colson, David D. Thomas 1817-Pos Board B354 CALMODULIN ENHANCEMENT OF CARDIAC MUSCLE ACTIVATION IS DEPENDENT ON MYOSIN ISOFORM. Ronnie Chastain , Maicon Landim Vieira, Emrulla Spahiu, Weikang Ma, Vivek P. Jani, Jolanda van der Velden, Thomas C. Irving, Prescott B. Chase, Vasco Sequeira, Mamta Amrute-Nayak 10 , J. Renato D. Pinto 11 , Christopher N. Johnson 12 1818-Pos Board B355 EFFECTIVE DELIVERY OF THE C-TERMINAL END PEPTIDE OF CARDIAC TROPONIN T INTO CARDIOMYOCYTES TO THERAPEUTICALLY MODULATE CONTRACTILITY. Qiaobin Li , J.-P. Jin 1819-Pos Board B356 AAV DELIVERY AND CARDIAC MUSCLE EXPRESSION OF THE C-TERMINAL END PEPTIDE OF CARDIAC TROPONIN I IN VIVO CORRECTS HFPEF PHE NOTYPE OF TRANSGENIC MOUSE HEARTS EXPRESSING HYPERTROPHIC CARDIOMYOPATHIC ALPHA-TROPOMYOSIN MUTANT E180G. Han-Zhong Feng , J.-P. Jin 1820-Pos Board B357 MITOCHONDRIAL ACTIVITY COUPLED TO CARDIAC MYOCYTE CONTRAC TILITY. Theodore Kalogeris , Adam B. Veteto, Laurin M. Hanft, Kerry S. Board B358 EXPLORING THE EFFECT OF BINGE DRINKING ON PASSIVE CARDIO VASCULAR MECHANICS IN MICE. Melinda M. Wetzel , Emmaleigh N. Hancock, Ihsan Shawki Akili, Corina Miko, Colby Filosa, Maddy Orlowski, R. Chris Skinner, Matthew A. Caporizzo McDonald 1821-Pos

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