BPS2026 Program Book

New Council Meeting 8:00 am - 11:30 am, Room 313/314 Poster Viewing 8:00 am - 3:00 pm, Exhibit Halls ABC Symposium New and Notable 8:15 am - 10:15 am, Room 301/302

Platform Protein Dynamics and Allostery: Post-translational Modifications 8:15 am - 10:15 am, Room 201/202/203 Co-Chairs HIGH-THROUGHPUT BIOCHEMICAL PHENOTYPING OF SHP2 VARIANTS REVEALS MOLECULAR BASIS OF DISEASES AND ALLOSTERIC DRUG INHI BITION. Albert A. Lee , Daniel Mokhtari, Emily Egan, Stephen Blacklow, Dan M. Herschlag, Polly Fordyce 1945-Plat 8:30 am DISSECTING THE ACTIVATION MECHANISM OF THE BI-FUNCTIONAL KINASE/RNASE IRE1 WITH ORTHOGONAL CONTROL OVER OLIGOMER IZATION AND PHOSPHORYLATION. Swapnil Mukherjee , Vladislav Belyy 1946-Plat 8:45 am A NOVEL SPECTROSCOPIC APPROACH FOR DETECTING GLYCATION IN HUMAN SERUM ALBUMIN. Simangka Bor Saikia , Himanshi M. Devi, Rajaram Swaminathan 1947-Plat 9:00 am PURIFICATION AND CHARACTERIZATION OF THE IRON OXIDIZING PORIN, CYTOCHROME CYC2, FROM SEAFLOOR IRON-RICH MICROBIAL MATS. Josiane Azizi , Alain Dolla, Céline Rommevaux, Latifa Elantak, Hélene Gaussier, Matthieu Nouailler 1948-Plat 9:15 am DPAGT1: ANTICANCER TARGET AND MODEL PHOSPHOGLYCOSYLTRANS FERASE. Jacob Kirsh , Yusrah B. Kaudeer, Yancheng Evelyn Li, Bil Clemons 1949-Plat 9:30 am MECHANISTIC INSIGHT INTO DISEASE VARIANTS OF HUMAN GLUTA MINE SYNTHETASE. Emilio Mejia, Hiroki Yamamura, Markus Tecson, Emma Carroll, Eric R. Greene 1950-Plat 9:45 am ALLOSTERIC ACTIVATION IN MULTI-DOMAIN PROTEINS EXPLORED BY MULTISCALE SIMULATIONS: THE CASE OF PHOSPHATASE SHP2. Paolo Calligari , Federica Allegrini, Isabella Romeo, Mattia Carvetta, Lorenzo Stella, Gianfranco Bocchinfuso 1951-FlashTalk 10:00 am Travel Award Winner ELUCIDATING PARKIN’S MECHANISM OF ACTIVATION VIA INTEGRA TIVE COMPUTATIONAL TOOLS. Carlos U. Herrada , Kesaban Sankar Roy Choudhuri, Vanessa Leone 1952-FlashTalk 10:05 am COMPUTATIONAL DESIGN OF PROTEIN MINI-BINDERS AND MACRO CYCLES TARGETING CAV1.2 CHANNELS. Adriana Hernández González , Rose E. Dixon, Vladimir Yarov-Yarovoy 1953-FlashTalk 10:10 am MODELING RELATIONSHIPS IN MULTI-PHENOTYPE DEEP MUTATIONAL SCANNING USING GRAPH THEORY AND ENSEMBLE VIEW. Jingyou Rao , Mingsen Wang, Matthew Howard, Ever O’Donnell, Willow Coyote Maestas, Harold Pimentel Carlos Herrada, Medical College of Wisconsin, USA Eric R. Greene, San Francisco State University, USA 1944-Plat 8:15 am

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Co-Chairs Ariane Briegel, Institut Pasteur, France Ilya Levental, University of Virginia, USA No Abstract 8:15 am

RETHINKING RNA STRUCTURE: VISUALIZING MOLECULES IN MOTION BEYOND INFERRED FLEXIBILITY. Maximilia Frazao de Souza Degenhardt No Abstract 8:45 am REWRITING ACTIN TREADMILLING: LEIOMODIN IS A POINTED-END POLYMERASE. Shashank Shekhar No Abstract 9:15 am STRUCTURE-GUIDED CORRECTION OF CONGENITAL MYASTHENIA. 9:45 am HARD TO BEAT - LESSONS FROM HUMMINGBIRD TRANSTHYRETIN ABOUT PROTEIN STABILITY AGAINST SHEAR STRESS. Irina Ritsch Symposium Chair Stephanie Gantz, University of Iowa, USA No Abstract 8:15 am THE UNEXPECTEDLY COMPLEX NATURE OF ENDOGENOUS NEURONAL GPCR ASSEMBLIES. Bryan Roth 1940-Symp 8:40 am ILLUMINATING GPCR SIGNALING WITH INTEGRATIVE MODELING, STRUCTURAL DYNAMICS, AND AI-DRIVEN DISCOVERY. Marta Filizola 1941-Symp 9:05 am FROM CANNABIS TO CONDUCTANCE: CANNABINOID-INSPIRED STRATEGIES FOR STATE-SELECTIVE NAV INHIBITION. Mohammad-Reza Ghovanloo 1942-SympSelect 9:30 am STRUCTURES AND GATING OF PARTIALLY OCCUPIED KAINATE RECEPTOR HETEROMERS. Andreas Reiner , Nandish Khanra, Alexa Strauss, Laura Moreno Wasielewski, Chantal Malinger, Joel Meyerson, Josh T. Levitz 1943-Symp 9:50 am PROTON INHIBITION OF DELTA-1 GLUTAMATE RECEPTOR CURRENT. Andrew G. Kain, Stephanie C. Gantz Huanhuan Li No Abstract Biophysics of Neural Signaling 8:15 am - 10:15 am, Room 303/304

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