BPS2026 Program Book

Platform Ion Channel Regulation, Pharmacology, and Disease II 8:15 am - 10:15 am, Room 204/205/206 Co-Chairs Antonios Pantazis, Linköping University, Sweden Lei Shen, Yale University, USA 1954-Plat 8:15 am DE NOVO DESIGN OF ION CHANNEL MODULATORS USING DEEP LEARN ING FOR THERAPEUTIC APPLICATIONS. Diego Lopez Mateos , Hai M. Nguyen, Yang Zheng, Ryan L. Woltz, Matthew J. Marquis, Kush Narang, Adam Murray, Igor V. Vorobyov, Miao Zhang, Nipavan Chiamvimonvat, Heike Wulff, Vladimir Yarov-Yarovoy 1955-Plat 8:30 am STRUCTURAL BASIS FOR THE SUBTYPE-SELECTIVE ACTIVATION OF K CA 3.1 CHANNELS. Alena Ramanishka , Young Woo Nam, Joshua Nasburg, Yang Xu, Meng Cui, Heike Wulff, Miao Zhang 1956-Plat 8:45 am IS KCNA2 HAPLOINSUFFICIENT? Pei Xin Boon , Amaia Jauregi Miguel, Sumeyye Suheda Yasarbas, Serena Pozzi, Charmaine Ko, Amelle Shil lington, Antonios Pantazis 1957-Plat 9:00 am TMEM175 AS TARGET OF NEURODEGENERATION: NOVEL INSIGHT IN CHANNEL BIOPHYSICS FROM SCREENING TO LYSOSOMAL FUNCTIONAL ANALYSIS. Teresa Sorbo, Manuel Paina, Manuel Arcangeletti, Katja Blasi, Sara Martin, Andrea Carlo Rossetti, Donatella Bardelli, Fernanda Ricci, Silvia Cainarca, Jean-Francois Rolland , Anna Mondini 1958-Plat 9:15 am ATP SYNTHASE C-SUBUNIT LEAK CHANNEL ACTIVITY IN BIPOLAR DIS ORDER. Lei Shen , Jonghun Kim, Amrendra Kumar, Nelli Mnatsakanyan, Hilary P. Blumberg, In-Hyun Park, Elizabeth A. Jonas 1959-Plat 9:30 am STRUCTURAL RESOLUTION OF ORG34167 INHIBITION OF HCN1 CHAN NELS. Elizabeth D. Kim , Ian C. Forster, Christopher A. Reid, Crina M. 9:45 am A PLATFORM TO STUDY THE EFFECTS OF SMALL MOLECULES ON HV1 FUNCTION IN NEUTROPHILS. Daniel T. Koren, Jamison L. Nourse, Babu Nallareddy, Francesco Tombola 1961-FlashTalk 10:00 am CLASSIFICATION OF HCN1 MUTATION CLASSES GUIDES CORRECTIVE THERAPIES IN EIEE DYSFUNCTION. Anna Moroni , Roberta Castelli, Alessandro Porro, Anna Castellini, Andrea Saponaro, Dario DiFrancesco, Gerhard Thiel, Bina Santoro 1962-FlashTalk 10:05 am RECONSIDERING NATIVE PROTON CHANNEL COMPOSITION AND FUNC TION: AMYLOID PRECURSOR PROTEIN (APP) IS AN ACCESSORY SUBUNIT IN HV1 CHANNELS IN MICROGLIA. Yiwen Ding , Ruiming Zhao, Mahas weta Nayak, Steve A. Goldstein 1963-FlashTalk 10:10 am A MEMBRANE-DISRUPTIVE ACTION OF VBIT-4 CHALLENGES ITS ROLE AS A WIDELY USED VDAC OLIGOMERIZATION INHIBITOR. Varun Ravis hankar, Luís Borges-Araújo, Elodie Lafargue, Deborah Byrne, Nicolas Buzhinsky, Mya S. Wolfe, Wendy Fitzgerald, Nina Bautista, Bethel Bey ene, Motahareh Ghahari Larimi, Jean-Pierre Duneau, James N. Sturgis, Megha Rajendran, Sergey M. Bezrukov, Ignacio I. Casuso, Tatiana K. Rostovtseva, Lucie A. Bergdoll Nimigean 1960-Plat

Platform Membrane Active Peptides 8:15 am - 10:15 am, Room 207/208

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Co-Chairs Teresa Rodriguez-Garcia, University of Tennessee, Knoxville, USA Carolyn Shurer, University of Virginia, USA 1964-Plat 8:15 am A GPCR-MIMETIC DNA MACHINE FOR PROBING INTRACELLULAR RNA VIA TRANSMEMBRANE SIGNAL AMPLIFICATION. Ranjan Sasmal , Saanya Yadav, Gde Bimananda M Wisna, Carter Swanson, Himanshu Joshi, Rizal F. Hariadi 1965-Plat 8:30 am DETECTION AND CHARACTERIZATION OF SINGLE PROTEINS VIA MEM BRANE DEFORMATIONS. Vadim A. Frolov , Ksenia Ivanova, Javier Vera Lillo, Pedro Arrasate, Petr Kuzmin, Pavel Bashkirov 1966-Plat 8:45 am A GENUINE FLUORESCENT SENSOR FOR QUANTITATIVE IMAGING OF MEMBRANE TENSION FROM LIPOSOMES TO LIVE CELLS. Yiling Wang , YItong Liu, Zhixing Chen, Zheng Shi 1967-Plat 9:00 am MEASURING THE NANOSCALE ORGANIZATION OF LIVE CELL MEM BRANES. Kandice R. Levental , Carolyn Shurer, Ilya Levental 1968-Plat 9:15 am PH-RESPONSIVE PEPTIDE NANOPARTICLES DELIVER MACROMOLECULES TO CELLS VIA ENDOSOMAL MEMBRANE NANOPORATION. Ains Ellis, Eric Wu, Keynon Bell, Kalina Hristova, William C. Wimley 1969-Plat 9:30 am Travel Award Winner CYCLIC LIPOPEPTIDES (CLIPS) - MEMBRANE INTERACTIONS: INSIGHTS INTO MEMBRANE BINDING AND PERMEABILIZATION. Sarah Crocoll , Sinja Götz, Luisa Munz, Durga Prasad, Matthias Vanheede, Loretta Eggenreich, Sandro Keller, José C. Martins, Andreas Bechthold, Heiko H. 9:45 am THE C.ALBICANS VIRULENCE FACTOR CANDIDALYSIN SWITCHES PO LYMERIZATION MODE IN SOLUTION AND IN THE MEMBRANE. Teresa Rodriguez-Garcia , Sadie L. Nickles, Charles Russell, Gavin King, Francisco N. Barrera 1971-FlashTalk 10:00 am DECODING TEIXOBACTIN-LIPID II BINDING: HOW LOCAL ENVIRON MENTS AND HYDRATION SHAPE INTERACTION STRENGTH. Nolan Herron , Juan M. Vanegas 1972-FlashTalk 10:05 am PREDICTION AND CHARACTERIZATION OF HIV-1 FUSION PEPTIDE VARI ANTS THAT MODULATE VIRAL ENTRY VIA CONFORMATIONAL PLASTIC ITY. Jeffy Jeffy , Shreyaa Srinivasan, Peter Kasson 1973-FlashTalk 10:10 am EXPLORING THE UPTAKE OF A MODEL CELL-PENETRATING PEPTIDE IN LIPID VESICLES. John Werb , Wade F. Zeno Heerklotz 1970-Plat

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