BPS2026 Program Book

2096-Pos Board B54 PROBING UNCHARTED CONFORMATIONAL ENSEMBLES OF K2P CHAN NELS IN MEMBRANES BY PULSE DIPOLAR EPR SPECTROSCOPY. Yue Ma, Katrin Ackermann, Qaiser Waheed, Vincent Postis, Terry K. Smith, Bela E. Bode, Christos Pliotas 2097-Pos Board B55 MOLECULAR DYNAMICS INSIGHTS INTO LIPID-DEPENDENT CONFORMA TIONAL CHANGES OF MULTIDRUG RESISTANCE PROTEIN P-GLYCOPRO TEIN. Ahmed Shubbar , Mahmoud Moradi Protein Aggregates (Boards B56 - B81) 2098-Pos Board B56 INHIBITION MECHANISM OF DESIGNED PEPTIDES TARGETING ACID-ME DIATED TRANSTHYRETIN AGGREGATION. Xun Sun , Rose Pedretti, Jane Dyson, Lorena Saelices, Peter E. Wright 2099-Pos Board B57 EFFECT OF MOLECULAR CROWDING ON KAPPA CASEIN FIBRILS’ MECHANICS AND MORPHOLOGY. Bence Fehér 2100-Pos Board B58 A BRAIN OSMOLYTE INHIBITS Α-SYNUCLEIN FIBRILLATION: MYO-INOSI TOL FOR PARKINSON’S THERAPY. Ashiq Mahammad 2101-Pos Board B59 ELUCIDATING RECEPTOR LIGAND INTERACTIONS BETWEEN TAU AND LRP1. Harry Li , Elizabeth A. Komives 2102-Pos Board B60 COMPUTATIONAL CHARACTERIZATION OF THE AGGREGATION OF HU MAN GAMMAD-CRYSTALLIN (HΓD-CRYS) FOR THE POTENTIAL TREAT MENT FOR CATARACTS. Suhani Patel 2103-Pos Board B61 PROBING BIOMOLECULAR CONDENSATES: INSIGHTS FROM FLUORES CENCE STUDIES. Priyanshi Kalra 2104-Pos Board B62 LARGE-SCALE MOLECULAR DYNAMICS SIMULATIONS OF AMYLOID FIBRIL BREAKAGE MECHANICS IN EXPLICIT SOLVENT FOR COMPARI SON WITH AFM EXPERIMENTS. Joshua Gadingan , Adam R. Ingwerson, Gianmarc Grazioli 2105-Pos Board B63 Travel Award Winner NATURALLY OCCURRING BETANIN MODULATES OLIGOMER FORMATION OF ALZHEIMER’S DISEASE AMYLOID-ß PROTEIN. Michael J. Kaven , Nolan J. Foreman, Melissa A. Moss 2106-Pos Board B64 N-N-PROPYLNORAPOMORPHINE AS A MULTIFACETED MODULATOR OF HUNTINGTIN AGGREGATION AND MEMBRANE BINDING. Sanzida Alam , Justin A. Legleiter 2107-Pos Board B65 RUTHENIUM RED ALTERS HUNTINGTIN AGGREGATION AND BLOCKS ITS ABILITY TO ASSOCIATE WITH AND DAMAGE LIPID MEMBRANES. Pritom Kumar Biswas , Chathuranga Siriwardhana, Justin A. Legleiter 2108-Pos Board B66 SIMULATION REVEALS EMERGENT PATTERN FORMATION OF MEM BRANE PROTEINS WITHIN CURVED MEMBRANES. Ji Yeon Hyun , Emmet A. Francis, Padmini Rangamani 2109-Pos Board B67 PHYSICAL FACTORS INFLUENCING ON THE CONFORMATIONAL CHANGES IN HUMAN CYSTATIN C - AN AMYLOIDOGENIC PROTEIN. Maciej Kozak , Karolina Rucinska, Joanna Maksim, Michal Taube, Daria Wojciechowska,

Ewa Banachowicz, Zuzanna Pietralik-Molinska, Wojciech Kwiatek, Jo anna Slawek, Qingqiu Huang 2110-Pos Board B68 THE IMPACT OF DISTINCT MUTANT HUNTINGTIN AGGREGATES ON C. ELEGANS . Justin A. Legleiter 2111-Pos Board B69 Travel Award Winner LIPID-CALCIUM COORDINATION LIMITS AMYLOID-ΒETA AGGREGATE GROWTH AT MIXED MEMBRANE SURFACES. Meenal Jain , Silvina Ma tysiak 2112-Pos Board B70 STRUCTURAL CHARACTERIZATION OF TOXIC HIAPP OLIGOMERS VIA 2D IR SPECTROSCOPY AND IMMUNOSENSORS. Josee Maurais , Martin T. Zanni 2113-Pos Board B71 EXPLORING AMYLOID-BETA INTERACTIONS IN THE CONTEXT OF CAL CIFICATION RELATED DISEASES. Natasha Bercy , Alexander P. Plonski, Francesca M. Marassi, Galia T. Debelouchina 2114-Pos Board B72 PROTEIN AGGREGATION IN THE EYE LENS DUE TO THE SYNERGESTIC EFFECTS OF DEAMIDATION AND OXIDATION. Kirsten J. Lampi , Larry L. David, Kate Halverson-Kolkind, Martin Tovar Ramirez, Constance Kraay, Eugene Shakhnovich, David Thorn 2115-Pos Board B73 STRUCTURAL ANALYSIS OF AMYLOID AGGREGATES IN TREATMENT RELATED ALZHEIMER’S DISEASE USING CRYO-ELECTRON MICROSCO PY. Mohammed M. Alhadidy , Yang Yang 2116-Pos Board B74 ADUCANUMAB BINDING TO AΒ 1-42 FIBRILS ALTERS DYNAMICS OF THE N-TERMINAL TAIL WHILE PRESERVING THE FIBRIL CORE. Ravi S. Palani , Christopher Williams, Dev Thacker, Robert P. Silvers, Fang Qian, Paul Weinreb, Leonard J. Mueller, Sara Linse, Robert G. Griffin 2117-Pos Board B75 CRYOEM STRUCTURES OF IN VITRO INDUCED FULL-LENGTH TAU AMYLOIDS. Emily Hernandez , Emma Carroll, Jason E. Gestwicki, Eric R. Greene 2118-Pos Board B76 STRUCTURAL BASIS OF PSEUDOMONAS BIOFILM-FORMING FUNCTIONAL AMYLOID FAPC FORMATION. Umit Akbey 2119-Pos Board B77 DELAYING THE ONSET OF AGGREGATION ENABLES A STRUCTURAL MODEL OF A TOXIC AMYLOID OLIGOMER FOR HIAPP. Shivani T. Shivani , Brynn E. LeMasters, Thirupathi Ravula, Harrison J. Esterly, Martin T. Zanni 2120-Pos Board B78 TRACKING PRION EVOLUTION AS IT HAPPENS. Ioanna Chatzitheodo siou , Kezia Jack, Mark Batchelor, Jan Bieschke 2121-Pos Board B79 Travel Award Winner PHOTON COUNTING HISTOGRAM ANALYSIS OF MOLECULAR OLIGO MERIZATION STATE IN LIVING CELLS. Zixiao Li , Tyler Camp, Teak-Jung Oh, Yushan Li, Kai Zhang 2122-Pos Board B80 MULTI-PATHWAY AMYLOID AGGREGATION CAPTURES FIBRIL POLYMOR PHISM AND MORPHOLOGICAL EVOLUTION. Kamal Bhandari , Wuzhou Xiong, Tianyi Hou, Feng Ding

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