BPS2026 Program Book

Intracellular Calcium Channels and Calcium Sparks and Waves (Boards B172 - B181) 2214-Pos Board B172 THE GUT MICROBIOTA METABOLITE PHENYLACETYLGLYCINE REGULATES CARDIAC CA 2+ SIGNALING BY INTERACTING WITH ADRENERGIC RECEP TORS. Elisa Bovo , Aleksey V. Zima 2215-Pos Board B173 SYNERGISTIC EFFECTS OF SEX-SPECIFIC REMODELING AND T-TUBULE HETEROGENEITY ON TRIGGERED ARRHYTHMIAS IN ATRIAL FIBRIL LATION. Yixuan Wu , Michael A. Colman, William E. Louch, Haibo Ni, Eleonora Grandi 2216-Pos Board B174 THE FUNCTIONAL ROLE OF THE CARDIAC RYANODINE RECEPTOR N TERMINAL CPVT MUTATIONS IN THE CHANNEL’S GAIN-OF-FUNCTION PHENOTYPE. Roman Nikolaienko , Mostafa Mostafa, Alec Loftus, Elisa Bovo, Daniel Kahn, Peter Kekenes-Huskey, Aleksey V. Zima 2217-Pos Board B175 REDUCTIVE STRESS INDUCES SARCOPLASMIC RETICULUM CALCIUM MISHANDLING IN VENTRICULAR MYOCYTES. Brett Torrel, Sage Quiggle, Cole Bauer, Francisco J. Alvarado, Shanna Hamilton 2218-Pos Board B176 HIGHTHROUGHPUT SCREENING FOR RYANODINE RECEPTOR MODU LATORS USING A NOVEL GREEN ER CA 2+ SENSOR PROTEIN. Nagomi Kurebayashi , Takashi Murayama, Masatoshi Ito, Junji Suzuki, Kazunori Kanemaru, Masamitsu Iino, Takashi Sakurai 2219-Pos Board B177 COMPUTATIONAL MODELING REVEALS DETERMINANTS OF INCREASED ARRHYTHMOGENESIS AND CONTRACTILE DYSFUNCTION IN A RAB BIT MODEL OF HEART FAILURE WITH REDUCED EJECTION FRAC TION. Fazeelat Mazhar , Amin Forouzandehmehr, Ishaan Dhaliwal, Bence Hegyi, Donald M. Bers, Stefano Morotti 2220-Pos Board B178 COMPUTATIONAL ANALYSIS OF SEX-SPECIFIC VENTRICULAR MYOCYTE REMODELING IN AN OBESE-DIABETIC MOUSE MODEL OF HFPEF. Amin Forouzandehmehr , Fazeelat Mazhar, Christopher Y. Ko, Henk L. Granzier, Bence Hegyi, Donald M. Bers, Stefano Morotti 2221-Pos Board B179 EXCITATION-CONTRACTION COUPLING PLASTICITY IS REVEALED UPON DELETION OF RYR2 IN ADULT MOUSE VENTRICULAR MYOCYTES. Erick B. Rios Perez , Achal M. Gowda, Isabel Cecilia Garay, Sergio Estrada, Francisco Alvarado 2222-Pos Board B180 ENHANCED DEPOLARIZATION-INDUCED CALCIUM RELEASE BY CAV1.1 VARIANTS ASSOCIATED WITH MALIGNANT HYPERTHERMIA SUSCEPTI BILITY. Takashi Murayama , Takuro Numaga-Tomita, Hirotsugu Miyoshi, Tsuyoshi Ikeda, Keiko Mukaida, Takuya Kobayashi, Nagomi Kurebayashi, Tsutomu Nakada, Taichiro Tomida, Satomi Adachi-Akahane, Yasuo M. Tsutsumi, Mitsuhiko Yamada, Takashi Sakurai 2223-Pos Board B181 DUAL THERAPY WITH MONOAMINE OXIDASE A INHIBITION AND NRF2 ACTIVATION IMPROVES AUTONOMIC NERVOUS SYSTEM AND CARDIAC FUNCTION IN A MOUSE MODEL OF FRIEDREICH’S ATAXIA. Francisco Figueroa , Sherif Bahriz, Ryan Sellers, Claire B. Montgomery, Bing Xu, Gino Cortopassi, Yang K. Xiang, Elena N. Dedkova

2203-Pos Board B161 LAYER-DEPENDENT ELECTROSTATIC ENVIRONMENTS IN MULTILAMEL LAR AND UNILAMELLAR VESICLES. Ngan Nguyen, Maxim Voinov, Alex I. Smirnov, Tatyana I. Smirnova 2204-Pos Board B162 RECOVERING LIPID BILAYER STRUCTURAL PARAMETERS FROM CRYO-EM IMAGES. Frederick A. Heberle , Milka Doktorova, Neal Waxham 2205-Pos Board B163 X-RAY SCATTERING OF BIOMEMBRANE AND PROTEIN SYSTEMS AT NSF’S CHEMMATCARS 15-ID AT THE ADVANCED PHOTON SOURCE IN ARGONNE NATIONAL LABORATORY. Daniel H. Kerr , David J. Walwark, Wei Bu, Mati Meron, Mark Schlossman, Binhua Lin Mechanosensation (Boards B164 - B171) 2206-Pos Board B164 STRUCTURE-FUNCTION MODEL FOR THE LOAD DEPENDENCE OF THE MYOSIN DWELL TIME. Henry G. Zot 2207-Pos Board B165 CELL MEMBRANE PROPERTIES UPON AGGRESSIVENESS AND INVASIVE NESS OF GLIOBLASTOMA CELLS IN RELATION TO MECHANOSENSA TION. Daria Kovryzhenko , Alexis Devriendt, Noémie Avalosse, Philippe L. Gailly, Donatienne Tyteca, Joseph H. Lorent 2208-Pos Board B166 LINKS IN INNER-HAIR-CELL BUNDLES REGULATE FLUCTUATIONS THAT LIMIT THE THRESHOLD OF HEARING. Riccardo Marrocchio , Daibhid O Maoileidigh 2209-Pos Board B167 STICKING POINT BETWEEN E-CADHERIN AND EGFR COUPLES INTERCEL LULAR TENSION TO GROWTH SIGNALING. Deborah E. Leckband , Yubo Zou, Emaan Z. Rauf, Nick Allen 2210-Pos Board B168 ACTIN CONTRACTILITY AND CLATHRIN-COATED PITS ESTABLISH MID PLANE-PEAKED APICO-BASAL TENSION PROFILES IN HELA CELLS. Tan moy Ghosh , Anisha Majhi, Avijit Kundu, Ayan Banerjee, Bidisha Sinha 2211-Pos Board B169 LIVE-CELL COMPATIBLE EXPANSION VIA HYDROGELS ON A TENSILE IRIS-STRETCHER. Danielle R. Latham , Vignesh Venkataramani, Marouen Zammali, Ramita Arampongpun, Tejasvin Shrikanth, Roberto C. Andre sen Eguiluz, Laura C. Caba Sanchez, Lydia Kisley 2212-Pos Board B170 Travel Award Winner IN SILICO HIERARCHICAL AND CALCIUM-DEPENDENT MECHANICS OF INNER-EAR TIP LINKS UNDER RESTING TENSION. Haosheng Wen , Carter T. Wheat, Jasanvir S. Sandhu, Elakkiya Tamilselvan, Pedro De-la-Torre, Joseph C. Sudar, Travis Harrison-Rawn, Marissa Boyer, Qurat Ashraf, Marcos M. Sotomayor 2213-Pos Board B171 SEX- AND AGE-DEPENDENT MECHANISMS OF THE MECHANO-CHRONO TROPIC RESPONSE IN THE SINOATRIAL NODE. Jenson D. Aaron , Aleksei Averin, Isabella Doherty, Thomas Schrauth, Roman Y. Medvedev, Conor J. Neill, Stefano Morotti, Eleonora Grandi, Alexey V. Glukhov

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