BPS2026 Program Book

2274-Pos Board B232 DOMINANT EFFECTS OF CLCN4 NEURODEVELOPMENTAL DISEASE VARIANTS IN HETEROMERIC ENDOSOMAL CLC-3/CLC-4 TRANSPORT ERS. Abraham Tettey Matey, Alessandra Picollo, Francesca Sbrana, Maria Antonietta Coppola, Eugenia Rubino, Alice Giusto, Margherita Festa, Elena Angeli, Raffaella Barbieri, Paola Gavazzo, Michael Pusch 2275-Pos Board B233 MOLECULAR DETERMINANTS OF PH SENSING IN THE CHLORIDE IN TRACELLULAR CHANNEL 3 (CLIC3). Veronica Loyo-Celis , Aaryan Patel, Harmeet Rireika Bhachu, Shridhar Shridhar Sanghvi, Harpreet Singh 2276-Pos Board B234 EFFECTS OF POTENTIATORS ON ION TRANSLOCATION THROUGH THE CFTR CHANNEL. Ngoc Phuong Dung Ho , Tho H. Ho, Lam K. Huynh, James C. Gumbart 2277-Pos Board B235 Travel Award Winner REGULATION OF CFTR BY THE MEMBRANE PHOSPHOLIPID PIP2. Ioanna Maria Vynichaki , Diomedes E. Logothetis, Laszlo Csanady 2278-Pos Board B236 MOLECULAR DYNAMICS REVEAL MECHANISTIC DIVERGENCE BETWEEN THE TWO PORES OF FLUC. Fernando Montalvillo , Kira Mills, Hedieh Board B237 ASSEMBLY AND LIPID-GATING OF LRRC8A:D VOLUME-REGULATED ANION CHANNELS. Antony Lurie , Christina A. Stephens, David M. Kern, Katharine Henn, Naomi R. Latorraca, Steve G. Brohawn Microtubules, Structure, Dynamics, and Associated Proteins (Boards B238 - B256) 2280-Pos Board B238 A MECHANO-CHEMICAL MODEL FOR ΓTURC-MEDIATED MICROTUBULE NUCLEATION. Kenneth Tsui , Ao Ma 2281-Pos Board B239 ACCESSIBILITY OF THE ALPHA-TUBULIN C-TERMINAL TAIL IS NUCLEO TIDE DEPENDENT. Patrick DeLear , David Sept 2282-Pos Board B240 MULTISCALE MODELING FOR MICROTUBULE DYNAMICS: FROM BEND ING RELAXATION TO HYDROLYSIS KINETICS. Weizhi Xue , Jiangbo Wu, Gregory A. Voth 2283-Pos Board B241 COMBINING COMPUTATIONAL METHODS TO PROBE THE ALLOSTERIC EFFECTS OF TAU ON MICROTUBULES. Emily M. Stump , Maryum Irshad, Kassandra Ori-McKenney, Ruxandra I. Dima 2284-Pos Board B242 A MACHINE LEARNING APPROACH TO EXTRACTING PROTEIN-PRO TEIN BINDING ENERGIES FROM MOLECULAR DYNAMICS SIMULA TIONS. Maryum Irshad , Emily Stump, Carter St. Clair, Julie Schlanz, Kassandra M. Ori-McKenney, Ruxandra I. Dima 2285-Pos Board B243 JUPITER 2 (JPT2) IS A MICROTUBULE ASSOCIATED PROTEIN THAT COM PENSATES FOR LOSS OF EB. Morgan L. Pimm, Jacob I. Hamaker , Ryoma Ohi, Kristen J. Verhey 2286-Pos Board B244 MAP9 BINDS AROUND THE MICROTUBULE AND DISTINCTLY REGULATES MOTOR PROTEINS. Burak Cetin , Ahmet Yildiz, Aryan Taheri, Eva Nogales Torabifard 2279-Pos

2287-Pos Board B245 MODULATION OF MICROTUBULE LATERAL CONTACTS BY FLUORESCENT TAXOL BROADENS THE ARCHITECTURAL SELECTIVITY OF DOUBLE CORTIN. Varun Ramaswamy, Szymon W. Manka, Darsh Sharma, Anna Akhmanova, Ankit Rai, Carolyn A. Moores 2288-Pos Board B246 THE MICROTUBULE BINDING DOMAIN OF CAMSAP3 TRACKS MICRO TUBULE DAMAGE SITES BY RECOGNIZING INCOMPLETE PROTOFILA MENTS. Yang Yue , Takashi Hotta, Morgan Pimm, Lynne Blasius, Jessica Dawson, Ryoma Ohi, Kristen Verhey 2289-Pos Board B247 LATERAL PROTOFILAMENT INTERACTIONS PROMOTE MICROTUBULE COLD ADAPTATION: INSIGHTS FROM ALL-ATOM SIMULATIONS. Mahsa Mofidi , Abhilash Sahoo, Christopher J. Edelmaier, Gabriela Li, Jeffrey M. Moore, Sonya M. Hanson 2290-Pos Board B248 DISSECTING CYTOSKELETAL DYNAMIC INSTABILITY WITH PHUZ: A VIRAL TUBULIN HOMOLOG AS A MODEL SYSTEM. Archita Bhattacharya 2291-Pos Board B249 A MULTI-SCALE SIMULATION APPROACH TO ELUCIDATE PRC1-MEDIATED MICROTUBULE ORGANIZATION. Abhilash Sahoo , William Conway, Bryce Palmer, Christopher Edelmaier, Sonya M. Hanson, Daniel Needelman, Michael Shelley 2292-Pos Board B250 INFERENCE OF MOLECULAR-SCALE MECHANISMS OF PRC1 RESISTANCE TO MICROTUBULE PAIR SEPARATION. Daniel Steckhahn, Shane A. Fio renza, Ellinor Tai, Scott T. Forth, Peter R. Kramer , Meredith D. Betterton 2293-Pos Board B251 TAXOL STABILIZES MICROTUBULES BY RELIEVING HYDROLYSIS-DRIVEN STRAIN AT THE MICROTUBULE SEAM. Nicholas Vangos , Patrick DeLear, Marija Zanic, David Sept, Michael A. Cianfrocco 2294-Pos Board B252 Travel Award Winner UNCOVERING BIOPHYSICAL CHARACTERISTICS OF NONEQUILIBRIUM STEADY STATE(S) OF MICROTUBULE DYNAMICS. Sayandeepa Raha , Alex ander W. Simmons, Alan E. Lindsay, Holly V. Goodson 2295-Pos Board B253 IN VITRO RECONSTITUTION OF THE INTERPLAY BETWEEN THE TUBU LIN- AND MAP- CODES AND THEIR EFFECTS ON KINESIN MOTILITY. Jon T. Fernandes , Viola Zhao, Parnika Kant, Ahmet Yildiz 2296-Pos Board B254 STRUCTURAL BASIS OF TUBULIN POST TRANSLATIONAL MODIFICA TION RECOGNITION BY EML PROTEINS. Aryan Taheri , Burak Cetin, Jon Fernandes, Ahmet Yildiz, Eva Nogales 2297-Pos Board B255 MICROTUBULE DAMAGE SENSOR SSNA1 REINFORCES THE MECHANI CAL STRENGTH OF MICROTUBULES. Laura B. Richardson , Elizabeth Lawrence, Abinaya Pinjakan, Marija Zanic 2298-Pos Board B256 STRUCTURE-BASED MECHANO-CHEMICAL MODEL REVEALS HOW MI CROTUBULES NUCLEATE FROM STABILIZED SEEDS. Ao Ma , Kenneth Tsui, Shannon F. Stewman

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