BPS2026 Program Book

Ion Channels, Pharmacology, and Disease II (Boards B221 - B230)

2250-Pos Board B208 STRUCTURAL CHARACTERIZATION OF A 5-HT 3 RECEPTOR ALLOSTERIC MODULATOR AND ITS EFFECTS ON ORTHOSTERIC AGONISM. Madeleine M. Stauffer , Kevin C. Felt, Henock Befekadu, Anshul Assaiya, Sudha Chakrapani 2251-Pos Board B209 DIRECT INTERACTION OF RIC3 WITH 5HT3A RECEPTORS IN MAMMA LIAN CELLS. Nermina Sarayli Belirgen , Petar Grozdanov, Rhea Ramani, Cade Perkins, Clinton MacDonald, Quynh Hoa Do, Lauren E. Anderson, Joshua J. Theriot, Michaela Jansen 2252-Pos Board B210 COMPARISON OF DISTINCT ALLOSTERIC MODULATOR SITES OF NICO TINIC RECEPTORS BY MOLECULAR DYNAMICS. Lorraine Antwi, Rosy Bang, Mark M. Levandoski , Yuxuan Zhuang, Rebecca J. Howard, Erik R. Lindahl 2253-Pos Board B211 REGULATORY ROLE OF THE L1-MX SEGMENT IN THE BIOGENESIS OF ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTORS. Quynh Hoa Do , Irina Kim Cavdar, Petar Grozdanov, Joshua J. Theriot, Rhea Ramani, Michaela Jansen 2254-Pos Board B212 STRUCTURAL UNDERPINNINGS OF BCL-2 AND IP 3 R INTERAC TIONS. Guizhen Fan, Xiaowei Zhang , Ariel Martinez Chavez, Mariah R. Baker, Walker Payne, Ian de Ridder, Geert Bultynck, Irina I. Serysheva 2255-Pos Board B213 STRUCTURAL AND FUNCTIONAL MODULATION OF HOMOMERIC GLUK2 RECEPTORS BY ACIDIC PH. Ashish Apotikar , Cuauhtemoc U. Gonzalez, Vasanthi Jayaraman 2256-Pos Board B214 KATP GATING CONFORMATIONAL CHANGES MEASURED USING FRET. Malia Ruggiero , Molly Girzadas, Michael C. Puljung 2257-Pos Board B215 MODULATION OF THE GAMMA-AMINOBUTYRIC ACID TYPE A RECEPTOR BY SCUTELLARIA LATERIFLORA. Teigan A. Brown , Jeremy A. Teissere 2258-Pos Board B216 STRUCTURAL INSIGHTS INTO THE GATING OF HUMAN P2X2 RECEPTOR CHANNELS. Surbhi Dhingra , Maia Moog, Kenton Swartz 2259-Pos Board B217 Travel Award Winner DETERMINING THE STOICHIOMETRY OF ASIC1/ASIC2 USING A NOVEL TWO-COLOR STEPWISE PHOTOBLEACHING APPROACH. Tristan C. Paul , John R. Bankston 2260-Pos Board B218 STRUCTURAL MECHANISM OF LIPID MODULATION OF PENTAMERIC LIGAND GATED ION CHANNEL ACTIVITY. Brandon Tan , Jesse Sandberg, Grace H. Brannigan, Wayland W. Cheng 2261-Pos Board B219 X-RAY SINGLE-MOLECULE DETECTION OF ACTIVATED Α7 NICOTINIC ACETYLCHOLINE RECEPTORS USING CAGED-ACETYLCHOLINE. Yue Yang , Haruto Machida, Kazuhiro Mio, Hirohisa Ohmiya, Satoshi Arai, Yuto Sumida, Yuji C. Sasaki 2262-Pos Board B220 Travel Award Winner A SINGLE ARGININE IN ASIC3 IS REQUIRED FOR MAXIMAL CHANNEL REGULATION BY DHA. Rebecca Roth , Ramya Bandarupalli, Jing Li, John Bankston

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2263-Pos Travel Award Winner PROBING THE CARDIAC K IR 2.1-NA V 1.5 CHANNELOSOME USING TRAF FICKING AND GATING-DEFECTIVE ARRHYTHMIA-ASSOCIATED KCNJ2 VARIANTS. Joseph Carr , Graham Stuart, Stephen Harmer, Jules Hancox 2264-Pos Board B222 REAL-TIME ELECTRONIC EXPRESSION OF LIGAND-GATED CHANNELS IN LIVING NEURONS USING DYNAMIC CLAMP. Mark W. Nowak , Brian K. Panama, Leigh Korbel, Lars Nilsson, Shivani Acharya, Randall L. Rasmus son, Glenna C.L. Bett 2265-Pos Board B223 MODELING SIMULTANEOUS BINDING OF DRUGS AND SEX-STEROID HORMONES TO THE HERG CHANNEL TO PREDICT SEX-SPECIFIC AR RHYTHMIA RISK. Sophia A. Brunkow , Jiaying Yan, Junko Kurokawa, Igor V. Vorobyov, Kyle C. Rouen 2266-Pos Board B224 SINGLE BK CHANNEL ACTIVITY FROM SKIN BIOPSIES OF HETEROZYGOUS INDIVIDUALS WITH NEUROLOGICAL DISORDER. Ria Dinsdale, Andrea Board B225 MODULATORY MECHANISMS OF G-PROTEIN-GATED INWARDLY REC TIFYING K + CHANNEL BY NATURAL PRODUCTS. I-Shan Chen , Jumpei Yasuda, Takuya Notomi, Tomoe Y. Nakamura 2268-Pos Board B226 DEFINING THE EFFECTS OF COMMON SUR2A TRUNCATION MUTATIONS ON SKELETAL MUSCLE FUNCTION. Rosa Scala , Yuezhou Chen, Gretchen Meyer, Conor McClenaghan, Colin G. Nichols 2269-Pos Board B227 FUNCTIONAL CHARACTERIZATION OF NOVEL ABCC8 MUTATIONS CAUS ING LOSS-OF-FUNCTION OF PANCREATIC K ATP CHANNELS - BUT PARA DOXICAL DIABETES PHENOTYPE. Rosa Scala , Hao Zhang, Jian Gao, Colin Board B228 COMPUTATIONAL MODELING OF ATRIAL FIBRILLATION-ASSOCIATED CA 2+ (DYS)REGULATION IN HUMAN ATRIAL FIBROBLASTS. Albert Lam , Najme Khorasani, Marcel Tekook, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi 2271-Pos Board B229 HIGH-THROUGHPUT AUTOMATED PATCH-CLAMP OF LYSOSOMAL CHANNEL TRPML1 USING SOPHION BIOSCIENCE PLATFORMS. Eliška Waloschková, Bastian Masson, Gabrielle Moody , Alexandre Santinho, Anissa Bara 2272-Pos Board B230 COMPARATIVE STUDY OF COMPREHENSIVE IN VITRO PROARRHYTHMIA ASSAY (CIPA) VOLTAGE-GATED ION CHANNELS UNDER PHYSIOLOGICAL TEMPERATURE USING HIGH-THROUGHPUT AUTOMATED PATCH CLAMP SYSTEM QPATCH AND QUBE 384. David Nagy , Kazuya Tsurudome, Patric Vaelli, Naja Møller Sørensen, Hironori Oshiro, Taku Izumi, Rasmus B. Jacobsen Anion Channels (Boards B231 - B237) 2273-Pos Board B231 EFFECTS OF PORE ANIONS ON THE SLOW GATING OF CLC-0. Tsung-Yu Chen , Pei-Cheng Li, Mei-Fang Chen, Tzyy-Leng Horng, Shu-Wei Chang Board B221 Meredith 2267-Pos G. Nichols 2270-Pos

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