BPS2026 Program Book

Protein Design (Boards LB1 - LB12)

Membrane Protein Dynamics (Boards LB13 - LB19) L2841-Pos Board LB13 PIEZO1 DECODES MECHANICAL FORCES VIA ALLOSTERIC NETWORK REPROGRAMMING. Yuling Zhang L2842-Pos Board LB14 IN SMALL NANODISCS, SIMPLE LIPID COMPOSITIONS FORM STRUC TURES THAT MODULATE THE CONFORMATIONAL DISTRIBUTION OF MEMBRANE RECEPTORS. Veera Hagg , Ilya Levental, Shreyas Kaptan, Ilpo Board LB15 A MULTISCALE COMPUTATIONAL APPROACH TO IDENTIFY NOVEL VIRAL EPITOPES BY TARGETING MHC-TCR COMPLEXATION. Jaya Vasavi Pamidimukkala , Roshan Balaji, Nirav Bhatt, Sanjib Senapati L2844-Pos Board LB16 UNRAVELING DIMERIZATION DYNAMICS AND MUTANT-INDUCED DYSREGULATION OF THE ERBB FAMILY RECEPTORS VIA LONG-TERM SINGLE-MOLECULE IMAGING. Kaibo Ma , Xiaojie Ma, Joao F. Shida, Zijian Niu, Yuzhu K. Lin, Saptarshi Mandal, Alexandra Dobbins, Lior Golomb, Michael J. Eck, Heidi Greulich, Matthew Meyerson, Sam Peng L2845-Pos Board LB17 CHARACTERIZING THE ROLE OF CONFORMATIONAL ENTROPY IN INTEGRAL MEMBRANE PROTEIN FOLDING AND FUNCTION. Kelly Risch , Taylor Cole, Josh Wand L2846-Pos Board LB18 PFAQP POLYOL TRANSPORT FREE ENERGY LANDSCAPES FROM UM BRELLA SAMPLING REVEAL INHIBITORY MECHANISMS AND ENABLE SITE-AWARE MSΛD RANKING. Blessing Oloyede L2847-Pos Board LB19 MULTISCALE MODELING OF SARS-COV-2 ORF7A-BST-2 INTERFACES RE VEALS A STRUCTURAL BASIS FOR BST-2 ANTAGONISM. Min-Kang Hsieh , Jeffery B. Klauda Protein Aggregates (Boards LB20 - LB32) L2848-Pos Board LB20 CRYO-EM AND BIOPHYSICAL INVESTIGATION OF AGGREGATION PATH WAY OF HUMANΓD-CRYSTALLIN. Sujata Malik , Ashwani K. Thakur L2849-Pos Board LB21 CRYO-EM COMPARISON OF CURVILINEAR PROTOFIBRILS AND AMYLOID FIBRILS IN TWO AMYLOIDOGENIC PROTEINS. Naoki Yamamoto , Ray mond Burton-Smith, Jin Inoue, Ken Morishima, Rintaro Inoue, Ritsumi Saito, Kei Nanatani, Ai Takahashi, Seizo Koshiba, Masaaki Sugiyama, Kazuyoshi Murata, Ryo Kanno, Eri Chatani L2850-Pos Board LB22 BAKUCHIOL, A PLANT MEROTERPENOID, INHIBITS THE PHASE SEPA RATION AND AGGREGATION OF TAU. Rajeshkumar S. Gop , Rishav Adhikary, Dulal Panda L2851-Pos Board LB23 FLUORESCENCE LIFETIME IMAGING REVEALS A CONCENTRATION DEPENDENT ASSEMBLY OF A BACTERIAL AMYLOID. Julian Y. Chen , Alexander M. Buendia, Sara H. Sohail L2852-Pos Board LB24 AMYLOID-MEDIATED RNA UPTAKE BY SPERM FOR EMBRYONIC DELIV ERY. Anthony Fitzpatrick Vattulainen L2843-Pos

L2829-Pos Board LB1 ENGINEERED ALLOSTERY FOR DE NOVO MOLECULAR SWITCH DE SIGN. Joseph Wang , Priyanka Joshi L2830-Pos Board LB2 MANIPULATION OF 7FINGER ZINC FINGER NUCLEASE INCREASES THE EFFICIENCY OF GENOME EDITING IN HUMAN CELLS. Shota Katayama, Masahiro Watanabe , Wataru Nomura, Takashi Yamamoto L2831-Pos Board LB3 DO CELL-FREE-PRODUCED ANTIBODIES MATCH CHO FOR BINDING AS SESSMENT? A HEAD-TO-HEAD BIOPHYSICAL COMPARISON. Kristin Mars L2832-Pos Board LB4 DESIGN OF AN INTERLEUKIN-2 BASED IMMUNOCYTOKINE FOR THE TARGETED EXPANSION OF MUSCLE REGULATORY T CELLS. Charina S. Fabilane , Jakub Tomala, Philip Farahat, Ella C. Teeley, Peiying Liu, Ar mando Villalta, Jamie B. Spangler L2833-Pos Board LB5 GENETICALLY ENCODED TOOL FOR PRECISE HYDROGEN PEROXIDE PRODUCTION: FROM CELL SIGNALING, PRODRUG MODIFICATION TO TRANSGENE EXPRESSION. Kriti Srivastava , Kayla L Petruzzi, Jacob Ren frow, Gary C. Mo L2834-Pos Board LB6 STRUCTURAL ANALYSIS OF ANTIBODY DOUBLE-POINT MUTATIONS USING AUTOMATED INTERACTION DESCRIPTORS INCLUDING WEAK INTERACTIONS. Shuntaro Chiba , Masateru Ohta, Tsutomu Yamane, Yasushi Okuno, Mitsunori Ikeguchi L2835-Pos Board LB7 INTEGRATED COMPUTATIONAL AND EXPERIMENTAL DEVELOPMENT OF HIGH AFFINITY NANOBODIES AGAINST A TUMOR ASSOCIATED ANTIGEN IN TRIPLE-NEGATIVE BREAST CANCER. Shahidul M. Islam L2836-Pos Board LB8 A DE NOVO SCAFFOLD FOR MINIMALISTIC CHANNEL AND TRANSPORT ER DESIGNS. Kehan Chen , William DeGrado L2837-Pos Board LB9 AN INTEGRATED USER-FRIENDLY WORKFLOW FOR AUTOMATED DE NOVO BINDER DESIGN. Pranav K. Kannan , Heman Burre, Fabiola Vacca, Daniel Marston, Mihai Azoitei L2838-Pos Board LB10 DE NOVO PROTEIN BINDERS TO PROBE MECHANISMS OF INNER-EAR MECHANOTRANSDUCTION. Ashley K. Le , Elektra Makris, Harper E. Smith, Emily Scheib, Travis Harrison-Rawn, Carter T. Wheat, Marcos M. Board LB11 SORTASE A PLATFORMS FOR SITE-SPECIFIC PROEIN LABELING AND PRECISION ANTIBODY CONJUGATION. Sean Greene, Ruey Ken, Robert Kennedy, Veronique Baron , Ali Yehia, Jonathan Mikolosko L2840-Pos Board LB12 ELICITING HUMAN IMMUNODEFICIENCY VIRUS (HIV)-1 IMMUNITY BY STIMULATING GERMLINE PRECURSORS OF PROTECTIVE ANTIBOD IES. Maria G. Juarez , Josh James Carter, Yu Lee, Christopher O. Barnes Sotomayor L2839-Pos

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