BPS2026 Program Book

L2853-Pos Board LB25 GEOMETRIC CHARACTERIZATION OF CONFORMATIONAL EPITOPES OF AMYLOID-BETA FIBRILS TO PREDICT EPITOPES. Masumi Sugiyama, Shin-ichi Tate L2854-Pos Board LB26 PHYSICOCHEMICAL DETERMINANTS OF FUNCTIONAL AMYLOIDS IN ESCHERICHIA COLI AND SALMONELLA TYPHIMURIUM . Weronika Grabowska , Peter Kunach, Jaime Vaquer-Alicea, Zuzanna Pietralik-Mo linska, Maciej Kozak L2855-Pos Board LB27 PROTEIN AGGREGATE DISASSEMBLY INTO FUNCTIONAL PROTEIN MONOMERS TO RE-INSTALL PROTEIN HOMEOSTASIS AND TO TREAT NEURODEGENERATIVE DISEASES. Dieter Willbold L2856-Pos Board LB28 A MINIMALLY PERTURBATIVE F15A HIAPP MOUSE MODEL REVEALS DIS TINCT AGGREGATION AND FUNCTIONAL PHENOTYPES. Dolimar Roldán Vélez , Martin T. Zanni L2857-Pos Board LB29 EVALUATING THE STRUCTURAL KINETICS OF ISOTOPICALLY LABELED S20G HIAPP AGGREGATION WITH 2D IR SPECTROSCOPY. Brynn E. LeMasters , Martin T. Zanni L2858-Pos Board LB30 STRUCTURAL DETERMINANTS OF PRION PROTEIN-FIBRIL RECOGNITION IN A MEMBRANE-ASSOCIATED CONTEXT: A STRUCTURAL BIOINFOR MATICS STUDY. Patricia Soto Becerra , Victoria Arellano, Sukhman Kaur, Jace Westphal L2859-Pos Board LB31 NOVEL TAU FILAMENT FOLDS IN INDIVIDUALS WITH FRONTOTEMPO RAL DEGENERATION CAUSED BY FAMILIAL TAU MUTATION. Henry Pan , Gregory E. Merz, Alissa Nana Li, Minh Le, Hyunil Jo, Athena Quddus, Anthony Yung, Rian C. Kormos, Eric Tse, Salvatore Spina, William F. DeGrado, William Seeley, Daniel R. Southworth L2860 -Pos Board LB32 NOVEL SMALL MOLECULE INHIBITS TDP-43 AGGREGATION AND RE STORES FUNCTION IN MODELS OF ALS/FTD. Shruti Arya , Marcela Kokes, Devi Korumilli, Vanessa Seawright, Cody Aldaz, Andrew Carr, Lewis Whitehead, Katie Planey, Vidhu Mathur Genome Maintenance (Boards LB33 - LB34) L2861-Pos Board LB33 A NON-CATALYTIC ROLE FOR RFC IN PCNA-MEDIATED PROCESSIVE DNA SYNTHESIS. Gabriella N. Chua , Emily C. Beckwitt, Victoria Miller-Browne, Olga Yurieva, Dan Zhang, Bryce J. Katch, Nina Y. Yao, John W. Watters, Kaitlin Abrantes, Ryogo Funabiki, Xiaolan Zhao, Michael O’Donnell, Shixin Liu L2862 -Pos Board LB34 DISSECTING THE MECHANISM OF REPRIMING DURING DNA DAMAGE RESPONSE USING SINGLE-MOLECULE IMAGING. Jinho Park , Gheorghe Chistol Protein-Nucleic Acid Interaction (Boards LB35 - LB49) L2863-Pos Board LB35 HIGH-THROUGHPUT IN VITRO MEASUREMENTS OF LIBRARY-ON LIBRARY PROTEIN-NUCLEIC ACID BINDING VIA STAMMP-SEQ. Renee Hastings , Michael G.B. Hayes, Lucas Melo, Alan Su, Polly Fordyce

L2864-Pos Board LB36 STRUCTURAL BASIS OF DHX29 FUNCTION SUGGESTS IT PULLS MRNA OPPOSITE TO THE SCANNING DIRECTION TO FACILITATE TRANSLATION INITIATION. Amedee des Georges , Da Cui, Irina Abaeva, Christopher U. Hellen, Tatyana Pestova L2865-Pos Board LB37 UNRAVELING PARP1-G4 INTERACTIONS: FROM BINDING TO PARYLA TION. Paras Gaur , Fletcher E. Bain, Riaz Meah, Maria Spies L2866 -Pos Board LB38 ACTIVITY OF SMC COMPLEX CLSN AT VARIED ACIDITY AND TEMPERA TURE. Gabriel Kenning L2867 -Pos Board LB39 SINGLE-MOLECULE MEASUREMENTS OF AN ANCESTRAL RNA-GUIDED NUCLEASE REVEAL R-LOOP DYNAMICS, DISCRETE INTERMEDIATES, AND MECHANISMS OF IMPROVED VARIANTS. Iren Saffarian-Deemyad , Zehan Zhou, Honglue Shi, Trevor Weiss, Kevin Aris, Noor Al-Sayyad, Jen nifer A. Doudna, Steve Jacobsen, Zev Bryant L2868 -Pos Board LB40 SINGLE-MOLECULE ANALYSIS REVEALS PEGRNA AUTOINHIBITION AS A DETERMINANT OF PRIME EDITING ACTIVATION. Yujin Kang , Taekjip Ha L2869-Pos Board LB41 MULTIPLE BINDING MODES OF MOUSE POT1 ON TELOMERIC DNA REVEALED BY SINGLE-MOLECULE FRET. Justin T-S. Diaz L2870 -Pos Board LB42 THE STRESS GRANULE-ENRICHED DSRNA SENSOR PKR AS AN RNASE L-DEPENDENT CELL FATE SWITCH. Ziqing Ye , Max Paget, Sun Hur L2871-Pos Board LB43 CHARACTERIZATION OF XPB TRANSLOCASE ON FLUORESCENTLY LA BELED DNA. Pavel Elian Morales Medina , K. Maria Mills L2872 -Pos Board LB44 THE RECOGNITION MECHANISM OF PATHOGENIC DNA BY IMMUNE SENSOR PROTEINS REVEALED BY SINGLE-MOLECULE STUDIES. Seth Durrant , Brenna Birnbaum, Eva De Alba L2873-Pos Board LB45 DNA LOOPING BY TYPE I RESTRICTION ENZYME NGOAVII STUDIED US ING MAGNETIC TWEEZERS. Farzaneh Alipoor Azizollahi, Paulius Toliušis, Mindaugas Zaremba, Algirdas Toleikis L2874-Pos Board LB46 INTERACTION OF THE PIONEER TRANSCRIPTION FACTOR SOX2 WITH DNA G-QUADRUPLEXES. Amanda L. Qu , Evgenia N. Nikolova L2875-Pos Board LB47 CHIMERIC MOTOR PRNA WITH ATP-BINDING COMPONENTS FOR ATPASE ACTIVITY PROVEN TO HAVE A STOICHIOMETRY OF 6: A MUL TIPLE OF 2 AND 3. Margaret Bohmer , Peixuan Guo L2876 -Pos Board LB48 SEQUENCE-DEPENDENT ENERGETICS AND DYNAMICS OF R-LOOP FORMATION BY CAS9. Noor Al-Sayyad, Joel J. Gates , Eryk J. Ratajczyk, Honglue Shi, Jonathan Bath, Ard A. Louis, Andrew Turberfield, Petr Sulc, Jennifer A. Doudna, Zev Bryant L2877 -Pos Board LB49 CYTOPLASMIC DYNAMICS AND MACROMOLECULAR ASSOCIATION USING MINFLUX SINGLE MOLECULE TRACKING. Sepehr Alaeen , Yuhan Wang, Yann R. Chemla, Martin Gruebele

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