BPS2026 Program Book

33-Plat 9:30 am DEEP SEA OSMOLYTE TMAO PROMOTES PHOSPHATIDYLETHANOL AMINE LIPID INTRINSIC CURVATURE, BALANCING THE EFFECT OF PRES SURE. Thomas R. Shaw , Ayesha Abha Amin, Prachi Patel, Zoe Beris, Edward R. Lyman, Stephen A. Sarles 34-Plat 9:45 am PROBING THE COUPLED EFFECTS OF MEMBRANE CURVATURE AND COMPOSITION ON LIPID PEROXIDATION. Juhee Kim , Stephanie N. Bartholomew, Wade F. Zeno 35-FlashTalk 10:00 am CURVATURE-DEPENDENT EFFECTS OF CHOLESTEROL ON DSPC BILAY ERS REVEALED BY ALL-ATOM MOLECULAR DYNAMICS SIMULATIONS. Ehsaneh Khodadadi , Ehsan Khodadadi, Parth Chaturvedi, Mahmoud Moradi 36-FlashTalk 10:05 am CONFORMATIONAL HETEROGENEITY DRIVES SARS-COV-2 FUSION PEPTIDE FUSOGENICITY. Shovon Swarnakar , Rajalakshmi Chockalin gam, Sumangal Rpychowdhury, Jhili Mishra, Ganapathy Ayappa, Jaydeep Kumar Basu 37-FlashTalk 10:10 am FORMATION OF MODEL MEMBRANE ARRAY BY SELF-SPREADING OF PHOSPHOLIPID BILAYERS AND ITS KINETIC ANALYSIS. Masako Fujii , Kenichi Morigaki Platform Muscles: Mechanics, Structure and Regulation 8:15 am - 10:15 am, Room 204/205/206 Co-Chairs THE STRUCTURE OF THE NATIVE CARDIAC CROSS-BRIDGE REVEALED BY CRYO-ELECTRON MICROSCOPY. Cristina M. Risi, Tyler Nguyen, Howard D. White, Prescott B. Chase, J. Renato D. Pinto, Vitold E. Galkin 39-Plat 8:30 am THE EFFECT OF SINGLE MYOSIN-HEADS ON THE POSITION OF TROPO MYOSIN ON ACTIN. Olga E. Karpicheva , Michael J. Rynkiewicz, William 8:45 am A FRET ASSAY TO MONITOR DIFFERENT STRUCTURAL STATES OF B CARDIAC MYOSIN INCLUDING THE INTERACTING-HEADS MOTIF. Rama Reddy Goluguri , Piyali Guhathakurta, Neha Nandwani, Aminah Dawood, Seiji Yokota, Osha Roopnarine, David D. Thomas, Kathleen Ruppel, James A. Spudich 41-Plat 9:00 am SEARCHING FOR THE SRX STATE OF MYOSIN IN SYNTHETIC THICK FILA MENTS. Kerry Y. Kao , Michael Regnier, Michael A. Geeves 42-Plat 9:15 am GETTING TO THE HEART OF HYPERTROPHIC CARDIOMYOPATHY WITH CRYOGENIC ELECTRON TOMOGRAPHY. Joseph Yoniles , Magda Za oralová, Giovanni Fajardo, PRERNA GIRI, Leeya Engel, Daniel Bernstein, Alexander R. Dunn, Peter D. Dahlberg 9,10 43-Plat 9:30 am DECODING THE MOLECULAR AND FUNCTIONAL CONSEQUENCES OF INTRINSIC DISORDER IN CARDIAC TROPONIN T. Ella I. Mozier , Jasmine Cubuk, Lina Greenberg, Melissa D. Stuchell-Brereton, Andrea Soranno, Michael J. Greenberg Rama Reddy Goluguri, Stanford University, USA Michelle S. Parvatiyar, Florida State University, USA 38-Plat 8:15 am Lehman 40-Plat

44-Plat 9:45 am HYPERTROPHIC CARDIOMYOPATHY-LINKED TNNC1 A8V MUTANT LOW ERS TETANIC FORCE GENERATION IN SOLEUS MUSCLE. Sonu Patel, Gabriel Leite da Silva Santos, Jaelynn Florence, Aida Rahimi Kahmini, Yun Shi, Michelle C. Rodriguez Garcia, Bradley S. Gordon, Prescott B. Chase, Christopher Solís, Orlando Laitano, J. Renato D. Pinto, Michelle S. Parvatiyar 45-FlashTalk 10:00 am A SLOW MYOSIN ISOFORM MAKES GRAY SQUIRREL JAW MUSCLES FAST OR SLOW. Sam Walcott , Varun Dhorajia, Brandon Reder, Daniel Bartlett, Robert J. Brocklehurst, Kayleigh J. Boos, Edward P. Debold, Jeffrey R. Moore, Nicolai Konow 46-FlashTalk 10:05 am ALTERED DYNAMICS IN SKELETAL MYOSIN WITH PATHOGENIC MISSENSE MUTATIONS. Ka Fu Man , Arianna Fornili 47-FlashTalk 10:10 am SPATIALLY EXPLICIT MCMC MODEL OF COMBINED THIN AND THICK FILAMENT COOPERATIVITY. Joy Pajarla , Stuart G. Campbell Platform Electron Microscopy 8:15 am - 10:15 am, Room 207/208 Co-Chairs Laina Hall, University of California Berkeley, USA Richard D. Leapman, NIBIB, NIH, USA 48-Plat 8:15 am MITIGATING CHARGE ACCUMULATION ON LAMELLAE DURING CRYO EM IMAGING WITH A LASER PHASE PLATE. Josh L. Dickerson , Laina Hall, Eric Cooper, Hang Cheng, Ian Hicklin, Yue Yu, Pavel Olshin, Garrett Greenan, Elizabeth Montabana, Anchi Cheng, Holger Müller, Bronwyn Lucas 49-Plat 8:30 am ENHANCEMENT OF SPATIAL RESOLUTION AND SIGNAL-TO-NOISE RATIO IN 3D IMAGING OF EMBEDDED CELLS AND TISSUES IN FOCUSED GA + ION BEAM SEM. Richard D. Leapman , Zijie Yang, Joshua C. Kim, Cameron M. Baenen, Samuel J. Fulton, Guofeng Zhang, Xiaobing Chen, Maria Aronova 50-Plat 8:45 am Travel Award Winner MOLECULAR PROBES FOR MULTICOLOR ELECTRON MICROSCOPY. Sohaib Abdul Rehman , Jeremy Conway, Debsankar S. Saha Roy, Jimmy Ching-Cheng Hsu, Simon Merminod, Maxim B. Prigozhin 51-Plat 9:00 am FLUORESCENCE-GUIDED FIB MILLING ACROSS SIZE SCALES WITH HIGH ACCURACY. Julia Peukes , Davis Perez, Sophia Betzler, Patrick Cleeve, Carmela Villegas, Cali Antolini, Sven Klumpe, Shu-hsien Sheu, Peter D. Dahlberg, Garrett Greenan, Bridget Carragher, David A. Agard 52-Plat 9:15 am CORRELATING PHYSIOLOGY AND STRUCTURE WITH FLUORESCENT BIO SENSORS AND CRYO-ET. Christopher A. Azaldegui , Davis D. Perez, Will Dwyer, Kevin M. Rose, Yue Rui, Jose Dinneny, Peter D. Dahlberg 53-Plat 9:30 am UNLOCKING CRYO-EM STRUCTURES: THE EMSUITE SERVER FOR HIGH ACCURACY MODELING AND ANALYSIS. Joon Hong Park , Javad Baghirov, Xiao Wang, Han Zhu, Genki Terashi, Yuki Kagaya, Pranav Punuru, Kai Ling, Shu Li, Yuanyuan Zhang, Daisuke Kihara

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