BPS2026 Program Book

426-Pos Board B238 PROFILING PHARMACOLOGY OF GPCRS BY TIME-RESOLVED IMPEDANCE MEASUREMENTS. Joachim Wegener, Martin Ziller, Ulrich Thomas, Ronald Knox , George Okeyo, Elena Dragicevic, Michael George, Niels Fertig, Sonja Stoelzle-Feix 427-Pos Board B239 CHEMICOGENETIC INVESTIGATION OF THE Α 2A ​ADRENERGIC RECEP TOR. Catherine H. Shin , Matthew K. Howard, Zara Y. Weinberg, Brian Shoichet, Willow Coyote-Maestas 428-Pos Board B240 Travel Award Winner UNDERSTANDING THE STRUCTURAL AND FUNCTIONAL LANDSCAPE OF CHOLESTEROL SENSING AND AUXIN SIGNALING BY HUMAN TRANSCEP TOR GPR155. Mansi Sharma 429-Pos Board B241 Travel Award Winner DECODING THE ROLE OF THE ECTODOMAIN ARCHITECTURE IN NATIVE STATE, ACTIVATION, AND INHIBITION OF THE NOTCH 1 RECEPTOR. Natalia S. Babilonia-Diaz , Andrew C.D. Lemmex, Wendy R. Gordon 430-Pos Board B242 TRANSPORT MECHANISM OF POLYAMINES IN MITOCHONDRIA. Hsiu Man Shih , Ming-Feng Tsai 431-Pos Board B243 AN IN VIVO BIOLUMINESCENT ASSAY PLATFORM FOR DETERMINING LIGAND-INDUCED ORPHAN GPCR/G-PROTEIN ACTIVATION. Sarah Son bati, Anne S. Robinson 432-Pos Board B244 SPATIAL RESTRICTION OF EGFR ACTIVATION FACILITATES THE SUPPRES SION AND EXTENSION OF CELL SIGNALING. Nicholas Duong , Aidan Brown 433-Pos Board B245 STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF SCUBE3 PROTEIN - A NOVEL ONCOGENIC LIGAND FOR EGFR. Rahul M. Mojidra , Deepika Singh, Manjeet Rao, Maria E. Falzone 434-Pos Board B246 COMPARATIVE PROXIMITY BIOTINYLATION MAPPING REVEALS THE ROLE OF ENDOLYSOSOMAL RETROFUSION IN INTRACELLULAR TRAF FICKING OF MONOCYTIC GPCRS. Alexis Lona , Thomas Shroka, Siyi Gu, Huaping Qin, Luya Wei, Sofia Endzhievskaya, Tony Ngo, Thy Nguyen, Mian Huang, Willow Carretero Chavez, JoAnn Trejo, Tracy M. Handel, Irina Kufareva Excitation-Contraction Coupling (Boards B247 - B258) 435-Pos Board B247 A COMPUTATIONAL MODEL OF OXIDATIVE STRESS IN A VENTRICULAR MYOCYTE. Hannah Zukowski , Gonzalo Hernandez Hernandez, Pei-Chi Yang, Colleen E. Clancy 436-Pos Board B248 COMPUTATIONAL ASSESSMENT OF THE REGULATION OF EXCITATION CONTRACTION COUPLING FKBP12.6 BY. Prakriti Panday , Aman Ullah, Mohsin S. Jafri 437-Pos Board B249 ALLOSTERIC GATING INTERACTIONS BETWEEN RYR CHANNELS JUSTIFY INTRACELLULAR CA 2+ RELEASE OF SKELETAL MUSCLE IN QUANTITATIVE DETAIL. Eduardo Rios , Gustavo Brum, Gonzalo Pizarro

438-Pos Board B250 PREVENTING PHOSPHORYLATION OF RAD AND PHOSPHOLAMBAN ABOLISHES THE CA(2+)-HANDLING CONTRIBUTION TO CARDIAC INOT ROPY DURING ADRENERGIC STIMULATION. Achal M. Gowda , Erick B. Rios Perez, Francisco J. Alvarado 439-Pos Board B251 TEMPORAL DYNAMICS OF CALCIUM RELEASE-DEPENDENT CAMKII-DEL TA ACTIVATION IN LIVE CARDIAC MYOCYTES. Christopher Y. Ko , Donald Board B252 STIM1-I115F CAUSING TUBULAR AGGREGATE MYOPATHY AND STOR MORKEN SYNDROME/YORK PLATELET SYNDROME INDUCES DEFECTS IN SKELETAL MYOTUBES. Seung Yeon Jeong , Huijin Lim, Semin Hong, Eun Hui Lee 441-Pos Board B253 MOLECULAR EFFECTS OF CAMKIIΔ S-NITROSYLATION IN CARDIOMYO CYTES. Adam J. Wilder , Christopher Y. Ko, Esther U. Asamudo, Bence Hegyi, Robyn T. Rebbeck, Donald M. Bers 442-Pos Board B254 INFERENCE FROM FRET MEASUREMENTS ON THE ORIENTATION OF THE CAV1.1 II-III LOOP RELATIVE TO RYR1. Danielle M. Heebner , Matthew J. Graham, Daniel J. Enders, Luyi Gao, Kurt G. Beam 443-Pos Board B255 CALSEQUESTRIN-2 PHOSPHORYLATION BY PROTEIN KINASE CK2 PRE DICTS AN IMPORTANT NEW FUNCTION IN THE CYTOSOL. Steven E. Cala 444-Pos Board B256 ELUCIDATION OF THE MEMBRANE BINDING PROPERTIES OF JUNC TOPHILIN. Zehua Shangguan , Marta Campiglio, Marc Yehya, Manu Ben Johny, Nazzareno D’Avanzo, Filip Van Petegem 445-Pos Board B257 RESOLVING CALMODULIN-RYR2 CONFORMATIONAL DYNAMICS BY REAL-TIME FRET IN PERMEABILIZED AND INTACT CARDIAC MYO CYTES. Victor Alencar Almeida , Christopher Y. Ko, Renee A. Gorman, Peter H. Backx, Robyn T. Rebbeck, Donald M. Bers 446-Pos Board B258 SUB-SARCOMERIC SPATIAL MULTIOMICS REVEALS DISTINCT ORGANI ZATION OF EXCITATION-CONTRACTION COUPLING MRNA TRANSLA TION. Bennett Yunker , Vladimir Bogdanov, Yiran Guo, Galina Sakuta, Juan I.E. Mariangelo, Sandor Gyorke Voltage-Gated K Channels (Boards B259 - B283) 447-Pos Board B259 MECHANISM OF KV CHANNEL INHIBITION BY 4-AMINOPYRIDINE, A CONDUCTION ENHANCING DRUG. Bernardo I. Pinto , Francisco Bezanilla 448-Pos Board B260 STRUCTURAL DETERMINANTS OF SUBTYPE SPECIFIC ACTIONS OF XE-991. Richard Kanyo , Shawn M. Lamothe, Thomas M. M Hammond, Harley T. Kurata 449-Pos Board B261 STRUCTURAL INSIGHTS INTO KV1.3 SELECTIVE INHIBITION BY PAP-1. Pu rushotham Selvakumar , Kenton Swartz 450-Pos Board B262 MOLECULAR AND ELECTROPHYSIOLOGICAL CHARACTERIZATION OF NO CICEPTIVE SCHWANN CELLS. Maia Moog , Kenton Swartz, Patrik Ernfors M. Bers 440-Pos

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