BPS2026 Program Book

451-Pos Board B263 VOLTAGE DEPENDENT BLOCK OF THE CARDIAC POTASSIUM CHANNEL HERG BY EXTRACELLULAR MONOVALENT, DIVALENT, AND TRIVALENT CATIONS. Wren Montijo, Christopher Nguyen, Chih Hsuan Kang, Haris Terovic, Alan Miller 452-Pos Board B264 FAM189A2 DEFICIENCY PROMOTES ATRIAL FIBRILLATION THROUGH IT O CURRENT ENHANCEMENT. Charles-Albert Chapotte-Baldacci , Takanori Aizawa, Olivier Bernus, Michel Haissaguerre, Vincent Fontaine, Pascale Guicheney, Mohamed Chahine 453-Pos Board B265 Travel Award Winner BIOPHYSICAL AND CELLULAR MECHANISMS BY WHICH HERG S4 VOLTAGE SENSOR MUTATIONS CONTRIBUTE TO LONG QT SYN DROME. Ruchael McNair , Isabella Doherty, Roshni Shetty, Eleonora Grandi, Matt C. Trudeau 454-Pos Board B266 CHEMICAL MODULATION OF THE KV1.2:SLC7A5 CHANNEL:TRANSPORTER COMPLEX. Nicholas Duta , Shawn M. Lamothe, Toru Tateno, Harley T. Kurata 455-Pos Board B267 EQUIVALENT GAIN-OF-FUNCTION VARIANTS IN KCNK3 AND KCNK9 AND THEIR CONTRIBUTION TO DISTINCT TASK K2P CHANNELOPATHIES. Kate M. Crowther , Thibault Jouen, Peter Proks, Peter Rory Hall, Janina Sörmann, Emma L. Veale, Karin E.J. Rödstrom, Thomas Müller, Caroline F. Wright, Simon Newstead, Alistair A. Mathie, Reza Maroofian, Stephen Board B268 SUDDEN DEATH-ASSOCIATED KCNH2 VARIANTS HAVE OPPOSING EF FECTS ON HERG1 NP FUNCTION. Francisco G. Sanchez-Conde, Matthew Goodrich, Olivia Stack, Louis Goldberg, Pamela Ruzycki, Abhilasha Jain, Eric N. Jiménez-Vázquez , David K. Jones 457-Pos Board B269 TRACKING THE HYDROPHOBIC GATE IN BK CHANNELS USING ANAP. Miguel Fernandez , Yichen Liu, Rosangelina Alvarado, Ramon Latorre, Francisco Bezanilla 458-Pos Board B270 Travel Award Winner FLIPPING GATING POLARITY IN HERG BY UNCOUPLING THE S4-S5 LINKER FROM THE INNER BUNDLE GATE. Zhen Tong , Ádám Fehér, Rong Shen, Trayder Thomas, Benoit Roux, Jamie I. Vandenberg, Eduardo Perozo 459-Pos Board B271 MOLECULAR INSIGHT INTO CHANNEL STOICHIOMETRY AND PIP 2 BIND ING OF K V 7.2/K V 7.3 CHANNELS WITH CAM-CA 2+ . Md Fulbabu Sk , Cade Duckworth, Ali A. Kermani, Hee Jung Chung, Emad Tajkhorshid 460-Pos Board B272 REDUCING THE KINETIC SOLUTION SPACE OF ION CHANNELS VIA I-V AND I-Μ ANALYSES. Alexander D. Daum , Jessica M. Swanson 461-Pos Board B273 EXPLORING THE INTERACTION BETWEEN KV2.1 AND AMIGO USING COMPUTATIONAL AND EXPERIMENTAL APPROACHES. Adrian Koretsky , Lucy R. Forrest, Kenton Swartz 462-Pos Board B274 Travel Award Winner REGULATION OF THE KCNQ4 CHANNEL VIA THE INTERPLAY BETWEEN PHOSPHORYLATION, CALMODULIN, AND PIP2. Phuc Phan , Divya Sap kota, Crystal R. Archer J. Tucker 456-Pos

463-Pos Board B275 THE SHAKER CHANNEL DOES NOT REQUIRE MECHANICAL BLOCKAGE OF THE GATE BY PROTEIN TO CLOSE: QUANTUM CALCULATIONS OF CONFINED WATER WITH IONS AT THE CHANNEL GATE. Alisher M. Kariev, Michael E. Green 464-Pos Board B276 K V 3.4 POTASSIUM CHANNEL GATING TRIGGERS FILOPODIAL ELON GATION BY BINDING PROTOHADHERIN 9. Yalan Zhang, Leonard K. Kaczmarek 465-Pos Board B277 VOLTAGE SENSOR CONFORMATIONS INDUCED BY LQTS-ASSOCIATED MUTATIONS IN HERG POTASSIUM CHANNELS. Co D. Quach , Aaron Chan, Lucas J. Handlin, Erin N. Lessie, Gucan Dai, Emad Tajkhorshid 466-Pos Board B278 QUANTUM CALCULATIONS ON SHAKER MUTANTS AT THE GATE SHOW ION DEHYDRATION AS PROTEIN PLUS CL- OUTCOMPETE K+ FOR WATER, WHILE THE CHANNEL CLOSES WITH PROTONS. Alisher M. Kariev , Michael E. Green 467-Pos Board B279 A RING OF LYSINES REVEALS INSIGHT INTO THE EXTRACELLULAR K+ - DEPENDENT CHANGES OF KV2.1 CONDUCTANCE. Danielle M. Heebner , Matthew J. Harper, Ana I. Fernández-Mariño 468-Pos Board B280 STRUCTURAL BASIS OF FAST N-TYPE INACTIVATION IN KV CHAN NELS. Xiaofeng Tan , Ana I. Fernández-Mariño, YAN LI, Tsg-Hui Chang, Kenton Swartz 469-Pos Board B281 ORTHOGONAL APPROACHES FOR DETERMINING THE STOICHIOMETRY OF HETEROMERIC HERG1A/1B CHANNELS. Sudharsan Kannan , Liliana R. Ernandez, Gail A. Robertson 470-Pos Board B282 CHANSPORTER INTERACTIONS LINK AN AE3 MUTATION TO SHORT QT SYNDROME. David Carreras, Rebecca Martinez-Moreno, Bernat Del Olmo, Oriol Canal Pujol, Ramon Brugada, Fabiana S. Scornik, Guillermo J. Perez 471-Pos Board B283 ENGINEERING BK CHANNEL-BASED CALCIUM SENSORS TO PROBE NANODOMAIN CA²⁺ DYNAMICS. Nadya Yanes-Alonso, Lidia Perez-Mar quez, Teresa Minguez Vinas, Diego Alvarez de la Rosa, David Bartolome Martin, Teresa Giraldez Membrane Pumps, Transporters, and Exchangers I (Boards B284 - B309) 472-Pos Board B284 Travel Award Winner REVEALING THE COMPLETE CREATINE PATHWAY THROUGH THE CRE ATINE TRANSPORTER AND INVESTIGATING THE MOLECULAR IMPACT OF MISSENSE MUTATIONS IN CREATINE TRANSPORTER DEFICIENCY. Pitambar Poudel 473-Pos Board B285 LOCAL RESIDUE PROTONATION STATES GOVERN THE CONFORMATION AL SWITCHING IN MITOCHONDRIAL PYRUVATE CARRIER. Yupeng Li , Christy Hadfield, Kyle McCommis, Reza Dastvan, Emad Tajkhorshid 474-Pos Board B286 CRYO-EM STRUCTURE REVEALS NA-DEPENDENT MECHANISM OF HUMAN OCA2. Poonam Dhankhar , Vishnu G. Ghani, Abdolkarim Far rokhzadeh, Olga Boudker

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